S1356 Correlation Between Systemic Inflammatory Markers and Evidence of Metastatic Disease in Patients With Hepatocellular Carcinoma

Abstract

Results: Cohort characteristics are displayed on Table . A total of 15,560 patients were examined. The mean age of the population was 47 (6 16) years. A greater proportion of patients were white (62%) and female (51%). Mean kPa and CAP were 6 kPa and 264 dB/m, respectably. On simple linear regression short sleep duration was significantly associated with hepatic steatosis (b 5 [8.4], p 5 [, 0.001]). Likewise, on multivariable linear regression after adjusting for age and body mass index (BMI), short sleep duration was significant associated with hepatic steatosis (b 5 [4.0], p 5 [0.013]). However, after adding sex to the model this association was no longer significant (b 5 [2.1], p 5 [0.152]). A relationship was not seen between sleep duration and hepatic fibrosis on unadjusted analysis or when controlling for the same variables described above. Conclusion: Overall, FibroScan® data in NHANES 2017-2020 support a positive association between short sleep duration and hepatic steatosis independently of metabolic factors such as BMI. Prospective studies are required to confirm this association. (Figure)