S1297 Review of Gastrointestinal Manifestations of Kohlmeier-Degos Disease

Sattler, Samantha; Shapiro, Lee

doi:10.14309/01.ajg.0000707236.05395.5a

Cited by 1 publication

(1 citation statement)

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“…Gastrointestinal diseases, the most common trouble in tropical countries, refer to diseases disturbing the gastrointestinal tract [ 1 , 2 ]. Common symptoms include vomiting and nausea, abdominal discomfort, diarrhea, acid reflux, unintentional weight loss, fatigue, swallowing difficulty, fever, black and bloody stool, gastrointestinal bleeding, and intestinal obstruction [ 3 ]. Gastrointestinal diseases are classified into two types as functional and structural.…”

Section: Introductionmentioning

confidence: 99%

Terazosin Stimulates Pgk1 to Remedy Gastrointestinal Disorders

Liu

Zhao

et al. 2021

IJMS

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Gastrointestinal disease is the most common health concern that occurs due to environmental, infectious, immunological, psychological, and genetic stress. Among them, the most frequent diseases are gastric ulcer (GU) and ulcerative colitis (UC). DSS-induced UC and ethanol-stimulated GU models resemble the pathophysiology of human gastrointestinal disease. The current study was designed to explore the anti-oxidation, anti-inflammation, anti-cell death properties of terazosin, an α-adrenergic receptor antagonist, in vivo and in vitro. Our results indicate that terazosin dramatically activates Pgk1, and upregulates glycose metabolism, evidenced by the enhanced ATP production and higher LDH enzymatic activity. Also, terazosin significantly enhances p-AKT expression and inhibits NF-κB p65 activation through abrogating the phosphorylation of IKBα, as well as lowers Caspase-1 and GSDMD expression. The findings in this study demonstrate that terazosin exhibits anti-inflammatory effects by downregulating NF-κB-GSDMD signal pathway, along with enhancing glycolysis for gastrointestinal disease treatment. Meanwhile, we also find terazosin ameliorates ethanol-induced gastric mucosal damage in mice. Collectively, as a clinical drug, terazosin should be translated into therapeutics for gastrointestinal disease soon.

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Section: Introductionmentioning

confidence: 99%