S1086 The Rising Incidence of Eosinophilic Esophagitis Correlates With Increased Awareness of the Disease

Andrews, Christopher N.; Syed, Atyab; Urbanski, Stefan J.; Beck, Paul L.; Storr, Martin

doi:10.1016/s0016-5085(10)60802-5

Cited by 1 publication

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“…Increased publication rates led to increased disease awareness and recognition. 13 Therefore we believe that these changes at least partially explain the increasing incidence of EoE. However, disease awareness is probably especially increased in specific sites more sensitized to EoE, whereas in other hospitals disease awareness may still be lacking.…”

Section: Discussionmentioning

confidence: 92%

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Incidence of eosinophilic esophagitis in the Netherlands continues to rise: 20‐year results from a nationwide pathology database

Warners

Rooij

Rhijn

et al. 2017

Neurogastroenterology Motil

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Background The incidence of eosinophilic esophagitis (EoE) has increased rapidly. Most epidemiologic data were gathered in single‐center studies over a short timeframe, possibly explaining the heterogeneous incidences. Aim The aim of this study was to retrospectively estimate the Dutch nationwide incidence of EoE over the last 20 years. Methods The Dutch pathology registry (PALGA) was queried to identify pathology reports describing esophageal eosinophilia from 1996 to 2016. Cases were eligible if EoE was confirmed by the pathologist. Using the annual Dutch population data, the incidence of EoE was calculated. Key Results The search yielded 11 288 reports of which 5080 described esophageal eosinophilia. Eosinophilic esophagitis was diagnosed in 2161 patients, 1574 (73%) males and 365 (17%) children. The incidence increased from 0.01 (95% CI 0‐0.02) in 1996 to 2.07 (95% CI 2.05‐2.23) per 100 000 inhabitants in 2015. The incidence was higher in males than in females, 3.02 (95% CI 2.66‐3.41) vs 1.14 (95% CI 0.93‐1.38), odds ratio (OR) 2.66 (95% CI 2.10‐3.36) and higher in adults than in children, 2.23 (95% CI 1.99‐2.49) vs 1.46 (95% CI 1.09‐1.91), OR 1.78 (95% CI 1.32‐2.40). Incidence of EoE increased more than 200‐fold, whereas endoscopy rates only tripled, from 30 in 1996 to 105 per 100 000 inhabitants in 2015. We observed no seasonal variation. Conclusions and Inferences In the last decades, the Dutch EoE incidence has increased tremendously and still continues to rise. This expansion is only partially driven by increased endoscopy rates.

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Section: Discussionmentioning

confidence: 92%

“…The rise in number of PubMed publications on EoE began in 2000, whereas it was not until 2005 that the incidence of EoE began to increase. Increased publication rates led to increased disease awareness and recognition . Therefore we believe that these changes at least partially explain the increasing incidence of EoE.…”

Section: Discussionmentioning

confidence: 92%