S1022 Treatment Preferences in Crohn’s Disease Perianal Fistula: Patient Perspectives

Athavale, Amod; Edelblut, Josiah; Chen, Minghua; Cazzetta, Susan; Nazarey, Pradeep; Fan, Tao; Hadker, Nandini; Jiang, Jeanne

doi:10.14309/01.ajg.0000860728.41531.11

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“…The key findings from this study are in keeping with the core outcomes identified by Sahnan et al [ 48 ] and are comparable with the findings of a recent study in a similar patient population conducted in the United States[ 48 , 49 ]. Further research on the potential impact of age, sex, and disease severity on patients’ treatment preferences could support healthcare professionals in the clinical management and treatment decisions for CPF.…”

Section: Discussionsupporting

confidence: 91%

Multi-national observational study to assess quality of life and treatment preferences in patients with Crohn’s perianal fistulas

Karki,

Athavale,

Abilash

et al. 2023

World J Gastrointest Surg

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BACKGROUND Patients with Crohn’s disease (CD) are at risk of developing complications such as perianal fistulas. Patients with Crohn’s perianal fistulas (CPF) are affected by fecal incontinence (FI), bleeding, pain, swelling, and purulent perianal discharge, and generally face a higher treatment burden than patients with CD without CPF. AIM To gain insights into the burden of illness/quality of life in patients with CPF and their treatment preferences and satisfaction. METHODS This cross-sectional observational study was conducted in patients with CD aged 21-90 years via a web-enabled questionnaire in seven countries (April-August 2021). Patients were recruited into three cohorts: Cohort 1 included patients without perianal fistulas; cohort 2 included patients with perianal fistulas without fistula-related surgery; and cohort 3 included patients with perianal fistulas and fistula-related surgery. Validated patient-reported outcome measures were used to assess quality of life. Drivers of treatment preferences were measured using a discrete choice experiment (DCE). RESULTS In total, 929 patients were recruited (cohort 1, n = 620; cohort 2, n = 174; cohort 3, n = 135). Short Inflammatory Bowel Disease Questionnaire scores were worse for patients with CPF (cohorts 2 and 3) than for those with CD without CPF (cohort 1): Mean score 3.8 and 3.7 vs 4.1, respectively, (P < 0.001). Similarly, mean Revised FI and FI Quality of Life scores were worse for patients with CPF than for those with CD without CPF. Quality of Life with Anal Fistula scores were similar in patients with CPF with or without CPF-related surgery (cohorts 2 and 3): Mean score 41 and 42, respectively. In the DCE, postoperative discomfort and fistula healing rate were the most important treatment attributes influencing treatment choice: Mean relative importance 35.7 and 24.7, respectively. CONCLUSION The burden of illness in CD is significantly higher for patients with CPF and patients rate lower postoperative discomfort and higher healing rates as the most desirable treatment attributes.

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Section: Discussionsupporting

confidence: 91%