Objective:There is scarce evidence revealing an association between job stress and cardiometabolic lifestyle modification behaviors among workers.Methods:A cross-sectional, correlation study was conducted among workers in high-risk and low-risk workplaces by work characteristics.Results:Workers in high-risk workplaces had significantly higher job stress levels than low-risk workplaces. Higher job stress was significantly associated with lower cardiometabolic lifestyle modification behaviors (β = −0.14, P = .001). This significant association was evident only for high-risk workplaces in total job stress (β = −0.16, P = .001), including job demand (β = −0.16, P = .005) and job insecurity (β = −0.11, P = .026).Conclusions:Strategies for alleviating job stress should be prioritized to high-risk workplaces, and these efforts may concomitantly contribute to cardiometabolic risk reduction.