S100P and HYAL2 as prognostic markers for patients with triple-negative breast cancer

Maierthaler, Melanie; Kriegsmann, Mark; Peng, Cike; Jauch, Sarah F.; Szabó, Ákos; Wallwiener, Markus; Rom, Joachim; Sohn, Christof; Schneeweiß, Andreas; Sinn, Hans‐Peter; Yang, Rongxi; Burwinkel, Barbara

doi:10.1016/j.yexmp.2015.06.010

Cited by 16 publications

(16 citation statements)

References 43 publications

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“…The elevated S100P expression is significantly associated with poor survival in operable breast cancer patients2157 or in triple-negative breast cancer patients58. Recently, Chung et al .…”

Section: Discussionmentioning

confidence: 99%

Distinct prognostic values of S100 mRNA expression in breast cancer

Zhang

Wang

Liu

et al. 2017

Sci Rep

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S100 family genes encode low molecular weight, acidic-Ca2+ binding proteins implicating in a wide spectrum of biological processes. S100 family contains at least 20 members, most of which are frequently dysregulated in human malignancies including breast cancer. However, the prognostic roles of each individual S100, especially the mRNA level, in breast cancer patients remain elusive. In the current study, we used “The Kaplan-Meier plotter” (KM plotter) database to investigate the prognostic values of S100 mRNA expression in breast cancer. Our results indicated that high mRNA expression of S100A8, S100A9, S100A11 and S100P were found to be significantly correlated to worse outcome, while S100A1 and S100A6 were associated with better prognosis in all breast cancer patients. We further assessed the prognostic value of S100 in different intrinsic subtypes and clinicopathological features of breast cancer. The associated results will elucidate the role of S100 in breast cancer and may further lead the research to explore the S100-targeting reagents for treating breast cancer patients.

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“…The elevated S100P expression is significantly associated with poor survival in operable breast cancer patients2157 or in triple-negative breast cancer patients58. Recently, Chung et al .…”

Section: Discussionmentioning

confidence: 99%

Distinct prognostic values of S100 mRNA expression in breast cancer

Zhang

Wang

Liu

et al. 2017

Sci Rep

View full text Add to dashboard Cite

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“…Several studies from Germany reported overexpression of S100P in BC, among other cancers33. In addition to their function as mediators of inflammatory responses, chemokines are involved in the regulation of tumor development and metastasis.…”

Section: Discussionmentioning

confidence: 99%

Gene expression profiling of breast cancer in Lebanese women

Makoukji

Makhoul

Khalil

et al. 2016

Sci Rep

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Breast cancer is commonest cancer in women worldwide. Elucidation of underlying biology and molecular pathways is necessary for improving therapeutic options and clinical outcomes. Molecular alterations in breast cancer are complex and involve cross-talk between multiple signaling pathways. The aim of this study is to extract a unique mRNA fingerprint of breast cancer in Lebanese women using microarray technologies. Gene-expression profiles of 94 fresh breast tissue samples (84 cancerous/10 non-tumor adjacent samples) were analyzed using GeneChip Human Genome U133 Plus 2.0 arrays. Quantitative real-time PCR was employed to validate candidate genes. Differentially expressed genes between breast cancer and non-tumor tissues were screened. Significant differences in gene expression were established for COL11A1/COL10A1/MMP1/COL6A6/DLK1/S100P/CXCL11/SOX11/LEP/ADIPOQ/OXTR/FOSL1/ACSBG1 and C21orf37. Pathways/diseases representing these genes were retrieved and linked using PANTHER®/Pathway Studio®. Many of the deregulated genes are associated with extracellular matrix, inflammation, angiogenesis, metastasis, differentiation, cell proliferation and tumorigenesis. Characteristics of breast cancers in Lebanese were compared to those of women from Western populations to explain why breast cancer is more aggressive and presents a decade earlier in Lebanese victims. Delineating molecular mechanisms of breast cancer in Lebanese women led to key genes which could serve as potential biomarkers and/or novel drug targets for breast cancer.

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“…In breast cancer, HYAL2 is overexpressed in the highly invasive tumor cells and may serve as an unfavorable prognostic marker for patients with triple-negative cancer. 8,20 On the contrary, overexpression of HYAL2 in lung cancer cells significantly suppressed growth of tumor xenografts and experimental lung metastasis in immunodeficient mice. 21 In lymphoma, HYAL2 expression correlates with diagnosis, but lowest HYAL2 expression is observed in high-grade lymphomas, suggesting a possible relation with an antioncogenic effect.…”

Section: Introductionmentioning

confidence: 97%

“…Like HYAL1, HYAL2 can function as either a tumor promoter or a tumor suppressor. In breast cancer, HYAL2 is overexpressed in the highly invasive tumor cells and may serve as an unfavorable prognostic marker for patients with triple‐negative cancer . On the contrary, overexpression of HYAL2 in lung cancer cells significantly suppressed growth of tumor xenografts and experimental lung metastasis in immunodeficient mice .…”

Section: Introductionmentioning

confidence: 99%

The suppressive role of HYAL1 and HYAL2 in the metastasis of colorectal cancer

Jin

Zhang

Liu

et al. 2019

J of Gastro and Hepatol

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Background Hyaluronidases (HAases), enzymes that degrade hyaluronan, have been widely investigated in cancer biology. However, whether HAases serve as tumor promoters or suppressors has been controversial in different cancers, and the exact role of HAases in colorectal cancer (CRC) has not been elucidated. Methods The expression levels of HYAL1, HYAL2, and HYAL3 in cancer and corresponding normal tissues from CRC patients were examined via immunohistochemistry. Then the correlation between HAases levels and pathological characteristics of CRC patients was analyzed. To verify the clinical data, HYAL1 and HYAL2 were downregulated or overexpressed in colon cancer cells LOVO and HCT116 to observe their influences on cell invasion and migration. For the mechanism study, we investigated the effects of HYAL1 and HYAL2 on the expression of matrix metalloproteases (MMPs)/tissue inhibitor of metalloproteases (TIMPs) and distribution of F‐actin. Results All the three HAases were abnormally elevated in cancer tissues. Interestingly, HYAL1 and HYAL2, but not HYAL3, were negatively correlated with lymphatic metastasis and TNM stage. When HYAL1 and HYAL2 were knocked down, the invasion and migration abilities of colon cancer cells were accelerated, whereas overexpression of HYAL1 and HYAL2 had the opposite effects. In addition, colon cancer cells with HYAL1 and HYAL2 downregulation showed increased levels of MMP2 and MMP9, decreased levels of TIMP1 and TIMP2, and more intense F‐actin stress fibers. Conclusions Our study suggests that HYAL1 and HYAL2 suppress CRC metastasis through regulating MMPs/TIMPs balance and rearranging F‐actin distribution, further inhibiting invasion and migration of cancer cells.

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S100P and HYAL2 as prognostic markers for patients with triple-negative breast cancer

Cited by 16 publications

References 43 publications

Distinct prognostic values of S100 mRNA expression in breast cancer

Distinct prognostic values of S100 mRNA expression in breast cancer

Gene expression profiling of breast cancer in Lebanese women

The suppressive role of HYAL1 and HYAL2 in the metastasis of colorectal cancer

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