S100B serum levels are closely correlated with body mass index: An important caveat in neuropsychiatric research

Steiner, Johann; Schiltz, Kolja; Walter, Martin; Wunderlich, Michael T.; Keilhoff, Gerburg; Brisch, Ralf; Bielau, Hendrik; Bernstein, Hans‐Gert; Bogerts, Bernhard; Schroeter, Matthias L.; Westphal, Sabine

doi:10.1016/j.psyneuen.2009.07.012

Cited by 103 publications

(89 citation statements)

References 14 publications

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“…S100B is secreted by adipocytes and is involved in the pathogenesis of obesity as shown in vitro (Fujiya et al, 2014) and in vivo (Buckman et al, 2014). Positive correlation of serum S100B with BMI was previously reported in a combined sample of cognitively intact lean and obese subjects (Steiner et al, 2010a) and in subjects with schizophrenia (Steiner et al, 2010b). In our study the positive correlation in the whole sample was likely driven by the healthy subgroup, with no such association in minor depressive episode.…”

Section: Discussionsupporting

confidence: 66%

First Evidence For Glial Pathology In Late Life Minor Depression: s100b Is Increased In Males With Minor Depression

et al. 2016

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Minor depression is diagnosed when a patient suffers from 2 to 4 depressive symptoms for at least 2 weeks. Though minor depression is a widespread phenomenon, its pathophysiology has hardly been studied. To get a first insight into the pathophysiological mechanisms underlying this disorder we assessed serum levels of biomarkers for plasticity, glial and neuronal function: brain-derived neurotrophic factor (BDNF), S100B and neuron specific enolase (NSE). 27 subjects with minor depressive episode and 82 healthy subjects over 60 years of age were selected from the database of the Leipzig population-based study of civilization diseases (LIFE). Serum levels of BDNF, S100B and NSE were compared between groups, and correlated with age, body-mass index (BMI), and degree of white matter hyperintensities (score on Fazekas scale). S100B was significantly increased in males with minor depression in comparison to healthy males, whereas other biomarkers did not differ between groups (p = 0.10-0.66). NSE correlated with Fazekas score in patients with minor depression (r s = 0.436, p = 0.048) and in the whole sample (r s = 0.252, p = 0.019). S100B correlated with BMI (r s = 0.246, p = 0.031) and with age in healthy subjects (r s = 0.345, p = 0.002). Increased S100B in males with minor depression, without alterations in BDNF and NSE, supports the glial hypothesis of depression. Correlation between white matter hyperintensities and NSE underscores the vascular hypothesis of late life depression.

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Section: Discussionsupporting

confidence: 66%

First Evidence For Glial Pathology In Late Life Minor Depression: s100b Is Increased In Males With Minor Depression

et al. 2016

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“…We also did not find any difference in triglyceride levels between violent and non-violent suicide attempters. This study also evaluated other markers related to adiposity, namely leptin, CRP and S100B (Eikelis et al, 2006;Steiner et al, 2010a). BDNF was also investigated because it is widely involved in body energetic homeostasis and commonly associated with psychiatric disorders with an elevated rate of suicide (Fernandes et al, 2013(Fernandes et al, , 2011Marosi and Mattson, 2014).…”

Section: Discussionmentioning

confidence: 99%

“…Serum S100B protein comes from the brain and from other non-neural sources, particularly adipose tissue (Goncalves et al, 2010. In fact, serum S100B levels in humans appear to closely reflect adipose tissue mass (Gross et al, 2010;Steiner et al, 2010a). Some studies have shown elevated levels of serum S100B in episodes of mood disorders, and these elevations were more evident in major depressive disorder than in bipolar disorder (Schroeter and Steiner, 2009).…”

Section: Discussionmentioning

confidence: 99%

Serum triglycerides, but not cholesterol or leptin, are decreased in suicide attempters with mood disorders

Cantarelli

Nardin

Buffon

et al. 2015

Journal of Affective Disorders

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“…Early studies show expression of S100B protein in pre-and mature-adipocyte and is induced during adipogenesis 62,63 . Physiological S100B levels appear to closely reflect adipose tissue mass or insulin resistance in humans [64][65][66] . HMGB1 is also found to be expressed in human adipose tissue with the expression level associated with the fat mass and obesity-associated gene 67 .…”

Section: Endogenous Rage Ligands Insulin Resistance and Metabolic Symentioning

confidence: 99%

AGE/RAGE as a Mediator of Insulin Resistance or Metabolic Syndrome: Another Aspect of Metabolic Memory?

Koyama¹,

Yamamoto²

2012

Biomedical Science, Engineering and Technology

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S100B serum levels are closely correlated with body mass index: An important caveat in neuropsychiatric research

Cited by 103 publications

References 14 publications

First Evidence For Glial Pathology In Late Life Minor Depression: s100b Is Increased In Males With Minor Depression

First Evidence For Glial Pathology In Late Life Minor Depression: s100b Is Increased In Males With Minor Depression

Serum triglycerides, but not cholesterol or leptin, are decreased in suicide attempters with mood disorders

AGE/RAGE as a Mediator of Insulin Resistance or Metabolic Syndrome: Another Aspect of Metabolic Memory?

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