S100B overexpression increases behavioral and neural plasticity in response to the social environment during adolescence

Buschert, Jens; Hohoff, Christa; Touma, Chadi; Palme, Rupert; Rothermundt, Matthias; Arolt, Volker; Zhang, Weiqi; Ambrée, Oliver

doi:10.1016/j.jpsychires.2013.08.001

Cited by 24 publications

(14 citation statements)

References 55 publications

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“…These contradictory findings indicate that the role of S100B in major depression is rather complex and still far from being understood. In a recent study, S100B overexpressing mice displayed an increased reactivity to environmental stimuli as shown by an increased behavioral and neural plasticity ( Buschert et al, 2013 ). Thus, elevated S100B expression might be associated with a differential susceptibility to environmental stimuli and could act as a plasticity factor in the way it has been proposed by Belsky and Pluess (2009) .…”

Section: Discussionmentioning

confidence: 99%

S100B Serum Levels Predict Treatment Response in Patients with Melancholic Depression

Ambrée

Grosse

Alferink

et al. 2015

IJNPPY

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Background:There is an ongoing search for biomarkers in psychiatry, for example, as diagnostic tools or predictors of treatment response. The neurotrophic factor S100 calcium binding protein B (S100B) has been discussed as a possible predictor of antidepressant response in patients with major depression, but also as a possible biomarker of an acute depressive state. The aim of the present study was to study the association of serum S100B levels with antidepressant treatment response and depression severity in melancholically depressed inpatients.Methods:After a wash-out period of 1 week, 40 inpatients with melancholic depression were treated with either venlafaxine or imipramine. S100B levels and Hamilton Depression Rating Scale (HAM-D) scores were assessed at baseline, after 7 weeks of treatment, and after 6 months.Results:Patients with high S100B levels at baseline showed a markedly better treatment response defined as relative reduction in HAM-D scores than those with low baseline S100B levels after 7 weeks (P=.002) and 6 months (P=.003). In linear regression models, S100B was a significant predictor for treatment response at both time points. It is of interest to note that nonresponders were detected with a predictive value of 85% and a false negative rate of 7.5%. S100B levels were not associated with depression severity and did not change with clinical improvement.Conclusions:Low S100B levels predict nonresponse to venlafaxine and imipramine with high precision. Future studies have to show which treatments are effective in patients with low levels of S100B so that this biomarker will help to reduce patients’ burden of nonresponding to frequently used antidepressants.

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Section: Discussionmentioning

confidence: 99%

S100B Serum Levels Predict Treatment Response in Patients with Melancholic Depression

Ambrée

Grosse

Alferink

et al. 2015

IJNPPY

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“…In addition, double S100A1/S100B knock‐out mice exhibit the same general behaviour (sociability, aggressiveness, curiosity, maternal behaviour) as wild‐type mice (J.C. Deloulme, E. Raponi & J. Baudier, unpublished data). Other studies show that the absence of S100B affects learning and emotional behaviour that may involve extracellular (paracrine) effects and astrocyte–neuron communication (Gerlai et al ., ; Nishiyama et al ., ; Buschert et al ., ). These two cognitive functions are not affected in S100A1‐deficient mice.…”

Section: S100b and S100a1 Protein Function: Lessons From Knock‐out Anmentioning

confidence: 97%

“…Whereas secretion of S100A1 from cells has not yet been observed, S100B secretion is abundantly documented and is recognized to play multiple extracellular roles among neurons and astrocytes (Gerlai et al ., ; Whitaker‐Azmitia, ; Nishiyama et al ., ; Buschert et al ., ). S100B can also enter the bloodstream and is one of the most studied serum biomarkers used to analyse brain injuries (reviewed in Thelin, Nelson & Bellander, ).…”

Section: Brain‐specific Extracellular S100b Functionsmentioning

confidence: 97%

The Zn²⁺ and Ca²⁺‐binding S100B and S100A1 proteins: beyond the myths

2020

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The S100 genes encode a conserved group of 21 vertebrate-specific EF-hand calcium-binding proteins. Since their discovery in 1965, S100 proteins have remained enigmatic in terms of their cellular functions. In this review, we summarize the calcium-and zinc-binding properties of the dimeric S100B and S100A1 proteins and highlight data that shed new light on the extracellular and intracellular regulation and functions of S100B. We point out that S100B and S100A1 homodimers are not functionally interchangeable and that in a S100A1/S100B heterodimer, S100A1 acts as a negative regulator for the ability of S100B to bind Zn 2+ . The Ca 2+ and Zn 2+ -dependent interactions of S100B with a wide array of proteins form the basis of its activities and have led to the derivation of some initial rules for S100B recognition of protein targets. However, recent findings have strongly suggested that these rules need to be revisited. Here, we describe a new consensus S100B binding motif present in intracellular and extracellular vertebrate-specific proteins and propose a new model for stable interactions of S100B dimers with full-length target proteins. A chaperone-associated function for intracellular S100B in adaptive cellular stress responses is also discussed. This review may help guide future studies on the functions of S100 proteins in general.Biological Reviews 95 (2020) 738-758

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“…Peer-reared animals with the L/S genotype had the highest ACTH levels during separations, but lowest in preseparation, control conditions. Buschert et al (2013) also reported an experiment with transgenic mice bearing 8 copies of a human gene that produces neurotrophic factor S100B that is associated with psychiatric disorders but also relates to better therapeutic outcomes in patients. S100B mice showed either reduced or elevated anxiety-related behavior in the open field test, depending upon their exposures in early life to stable or unstable social conditions.…”

Section: Allelic Variation and Differential Susceptibilitymentioning

confidence: 99%

Differential Susceptibility of the Developing Brain to Contextual Adversity and Stress

Boyce

2015

Neuropsychopharmacol

116

110

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A swiftly growing volume of literature, comprising both human and animal studies and employing both observational and experimental designs, has documented striking individual differences in neurobiological sensitivities to environmental circumstances within subgroups of study samples. This differential susceptibility to social and physical environments operates bidirectionally, in both adverse and beneficial contexts, and results in a minority subpopulation with remarkably poor or unusually positive trajectories of health and development, contingent upon the character of environmental conditions. Differences in contextual susceptibility appear to emerge in early development, as the interactive and adaptive product of genetic and environmental attributes. This paper surveys what is currently known of the mechanisms or mediators of differential susceptibility, at the levels of temperament and behavior, physiological systems, brain circuitry and neuronal function, and genetic and epigenetic variation. It concludes with the assertion that differential susceptibility is inherently grounded within processes of biological moderation, the complexities of which are at present only partially understood.

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S100B overexpression increases behavioral and neural plasticity in response to the social environment during adolescence

Cited by 24 publications

References 55 publications

S100B Serum Levels Predict Treatment Response in Patients with Melancholic Depression

S100B Serum Levels Predict Treatment Response in Patients with Melancholic Depression

The Zn²⁺ and Ca²⁺‐binding S100B and S100A1 proteins: beyond the myths

Differential Susceptibility of the Developing Brain to Contextual Adversity and Stress

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S100B overexpression increases behavioral and neural plasticity in response to the social environment during adolescence

Cited by 24 publications

References 55 publications

S100B Serum Levels Predict Treatment Response in Patients with Melancholic Depression

S100B Serum Levels Predict Treatment Response in Patients with Melancholic Depression

The Zn2+ and Ca2+‐binding S100B and S100A1 proteins: beyond the myths

Differential Susceptibility of the Developing Brain to Contextual Adversity and Stress

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The Zn²⁺ and Ca²⁺‐binding S100B and S100A1 proteins: beyond the myths