S100A9 in BALF is a candidate biomarker of idiopathic pulmonary fibrosis

Abstract

S100A9 in BALF might serve as a candidate biomarker to discriminate between IPF and other fibrotic interstitial pneumonias.

ABCG2pos lung mesenchymal stem cells are a novel pericyte subpopulation that contributes to fibrotic remodeling

“…This activation of TGF-␤ results in myofibroblast transition of fibroblasts as well as EC, increased collagen deposition (col1a1, col3a1), increased matrix stiffening, and adverse remodeling (41,46). S100A9, galectin 3 (Lgals3bp), and placental growth factor (pgf) have all been identified as biomarkers that indicate the severity of fibrosis in various tissues including IPF (18,39,76,95). Interestingly, galectin 3 interacts with NG2 and promotes migration and invasion of cells (97).…”

Advances in the study of biomarkers of idiopathic pulmonary fibrosis in Japan

“…It is reported to be a useful marker for non-infectious inflammatory diseases. A study of BALF (34) found that S100A9 levels were significantly higher in patients IPF than in patients with other IPDs and healthy volunteers.…”

Comparative Proteomic Analysis of Rat Bronchoalveolar Lavage Fluid after Exposure to Zinc Oxide Nanoparticles

“…22) In the same study, we also found that S100A8 and S100A9, candidate markers of idiopathic pulmonary brosis and lung cancer, 23,24) were signi cantly up-regulated following exposure. 22) Although LC-based separation technology coupled with MS/MS o ers a unique opportunity to rapidly, sensitively, and automatically identify proteins in protein mixtures, 25) two-dimensional gel electrophoresis (2-DE) o ers much higher resolution, allowing for the separation of up to 15,000 proteins.…”

“…Our results are consistent with those from previous studies that showed that exposure to ZnO NPs mainly induces lung in ammation and immune response in rats. 3,22) Although S100A8 and S100A9, candidate markers of idiopathic pulmonary brosis and lung cancer, 23,24) were not identi ed, pulmonary surfactant-associated protein D and gelsolin, biomarkers of idiopathic pulmonary brosis, [35][36][37] were signi cantly up-regulated in rat BALF a er ZnO NPs exposure (2.42-and 2.84-fold, respectively). Although it is necessary to further clarify the potential health risks associated with exposure to zinc oxide nanoparticles, the results obtained by gel-based proteomic analysis in this study and those obtained by an LC-based proteomic approach in our previous study 22) indicate that these in ammatory responses might induce idiopathic pulmonary brosis or lung cancer.…”