2021
DOI: 10.3389/fnins.2020.616559
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S100A8 Promotes Inflammation via Toll-Like Receptor 4 After Experimental Traumatic Brain Injury

Abstract: IntroductionS100 calcium-binding protein A8 (S100A8) is also known as macrophage-related protein 8, which is involved in various pathological processes in the central nervous system post-traumatic brain injury (TBI), and plays a critical role in inducing inflammatory cytokines. Accumulating evidences have indicated that toll-like receptor 4 (TLR4) is considered to be involved in inflammatory responses post TBI. The present study was designed to analyze the hypothesis that S100A8 is the key molecule that induce… Show more

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Cited by 11 publications
(12 citation statements)
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References 46 publications
(64 reference statements)
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“…To investigate the S100A8 expression after SCII, we examined the samples taken at different time points after establishing the ischemia/reperfusion model (Figure 5A ). As previously reported, the S100A8 protein level is significantly upregulated after post‐traumatic brain injury [ 20 ]. RNA sequencing results by qRT‐PCR showed S100A8 was increased 48 h after SCII [ 41 ].…”
Section: Resultssupporting
confidence: 69%
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“…To investigate the S100A8 expression after SCII, we examined the samples taken at different time points after establishing the ischemia/reperfusion model (Figure 5A ). As previously reported, the S100A8 protein level is significantly upregulated after post‐traumatic brain injury [ 20 ]. RNA sequencing results by qRT‐PCR showed S100A8 was increased 48 h after SCII [ 41 ].…”
Section: Resultssupporting
confidence: 69%
“…Sham rats were injected with 10 μl of normal saline. The process was performed following a previously reported method [ 20 , 29 ]. TAK‐242 was intraperitoneally injected (3 mg/kg) 30 min before the injection of rS100A8 [ 20 , 29 , 30 ].…”
Section: Methodsmentioning
confidence: 99%
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“…S100A8, S100A9, S100A12, and CTSG are all implicated in neutrophil function [ 42 , 43 ], with recent reports showing that S100A8 and S100A9 are associated with neuroinflammation in preclinical models of TBI [ 44 , 45 ]. A clinical study exploring the prognostic potential of S100A12 in severe TBI, found that its serum levels were significantly elevated compared to controls alongside other markers (e.g., S100B, CRP), and were also independently associated with mortality and adverse events [ 46 ].…”
Section: Discussionmentioning
confidence: 99%