S100A4 promotes liver fibrosis via activation of hepatic stellate cells

Chen, Lin; Li, Jie; Zhang, Jinhua; Dai, Chengliang; Liu, Xiaoman; Wang, Jun; Zhi, Gao; Guo, Hongyan; Wang, Rui; Lu, Shichun; Wang, Fusheng; Zhang, Henghui; Chen, Hongsong; Fan, Xiaoxuan; Wang, Shengdian; Qin, Zhihai

doi:10.1016/j.jhep.2014.07.035

Cited by 129 publications

(141 citation statements)

References 32 publications

Supporting

Mentioning

135

Contrasting

Order By: Relevance

“…21 , 29 , 30 To test whether S100A4 is secreted by S100A4 + cells in the CRC tissue, CD11b + S100A4 + cells were isolated from DSS-treated colon tissues and were cultured in vitro, and the supernatant was analyzed for S100A4 by ELISA. CD11b + S100A4 − cells were used as control.…”

Section: Resultsmentioning

confidence: 99%

“…S100A4 in cell culture supernatant and whole colon lysate were detected by sandwich ELISA as described previously. 21 …”

Section: Methodsmentioning

confidence: 99%

“…32 In previous studies, we found an additional mechanism of action that S100A4 + fibroblasts promote skin carcinogenesis by maintaining MCP-1-mediated macrophage infiltration and chronic inflammation. 20 In addition, we identified a critical role of S100A4 in promoting liver fibrosis through hepatic stellate cell activation, 21 and macrophage-derived S100A4 promotes liver carcinogenesis by promoting CD8 + T-cell survival (unpublished).…”

Section: Introductionmentioning

confidence: 94%

See 2 more Smart Citations

S100A4 promotes colon inflammation and colitis-associated colon tumorigenesis

Zhang

Hou

et al. 2018

OncoImmunology

Self Cite

View full text Add to dashboard Cite

S100A4 plays important roles in tumor development and metastasis, but its role in regulating inflammation and colitis-associated tumorigenesis has not been well characterized. Here, we report that S100A4 expression was increased in azoxymethane (AOM) and dextran sulfate sodium (DSS) induced colorectal cancer (CRC) in mice. After AOM/DSS treatment, both S100A4-TK mice with the selective depletion of S100A4-expressing cells and S100A4-deficient (S100A4−/−) mice developed fewer and smaller tumors than wild-type (WT) control littermates. Furthermore, S100A4−/− mice were resistant to DSS-induced colitis, reduced infiltration of macrophages, and the diminished production of proinflammatory cytokines. Further studies revealed that reduced colon inflammation and colorectal tumor development in S100A4−/− mice were partly due to the dampening of nuclear factor (NF)-κB activation in macrophages. Furthermore, the administration of a neutralizing S100A4 antibody to WT mice significantly decreased AOM/DSS-induced colon inflammation and tumorigenesis. These results indicate that S100A4 amplifies an inflammatory microenvironment that promotes colon tumorigenesis and provides a promising therapeutic strategy for treatment of inflammatory bowel disease and prevention of colitis-associated colorectal carcinogenesis.

show abstract

Section: Resultsmentioning

confidence: 99%

“…S100A4 in cell culture supernatant and whole colon lysate were detected by sandwich ELISA as described previously. 21 …”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 94%

See 1 more Smart Citation

S100A4 promotes colon inflammation and colitis-associated colon tumorigenesis

Zhang

Hou

et al. 2018

OncoImmunology

Self Cite

View full text Add to dashboard Cite

show abstract

“…Chronic, progressive renal injury results in renal fibrosis (Chen et al, 2014;Ji et al, 2014). Surprisingly, immunofluorescence and immunohistochemistry results revealed a marked increase in the accumulation of Col 1 and α-SMA+ myofibroblasts in the kidneys of the 5-week BDL-watertreated group, as determined by real-time PCR.…”

Section: Discussionmentioning

confidence: 91%

Xiayuxue decoction reduces renal injury by promoting macrophage apoptosis in hepatic cirrhotic rats

et al. 2015

View full text Add to dashboard Cite

ABSTRACT. Renal pathological changes in cirrhotic rat have not been extensively reported. The aim of this study was to investigate whether Xiayuxue decoction (XYXD) could attenuate renal injury induced by bile duct ligation (BDL), with special focus on the mechanisms promoting renal macrophage apoptosis. The rats were treated with BDL for 5 weeks and administered 0.36 g/kg XYXD intragastrically from day 1 of initiating BDL. Renal tissue was monitored by hematoxylin-eosin and Sirius red staining. Macrophage infiltration and proinflammatory cytokines such as tumor necrosis factor and chemokine ligand 2 were detected by quantitative polymerase chain reaction. Macrophage apoptosis was detected by double immunofluorescence staining. Blood urea nitrogen, creatinine, and glomerulus diameter increased significantly after a 5-week BDL treatment in XYXD (BDL-XYXD) rats. CD68 and pro-inflammatory cytokine (2015) mRNA increased in the kidneys of control (BDL-water) rats. Fluorescence microscopy analysis showed that XYXD promoted apoptosis in renal CD68+ macrophages. Collogen1 (Col 1), pro-fibrogenic cytokines, and α-smooth muscle actin in kidneys of BDL-water rats increased significantly compared to the sham group. XYXD inhibited Col 1 and pro-fibrotic factors in BDL-XYXD rats. Our results demonstrated that XYXD significantly reduced renal injury by, at least in part, promoting macrophage apoptosis in rats with damaged renal histopathology due to BDL-induced cirrhosis.

show abstract

“…On the basis of the available literature, where S100A4 was investigated either in the serum (51 studies; two of them in a relation to a gastroenterology disorderliver fibrosis and cirrhosis (44,45)) or in plasma samples (26 studies; two of them were accomplished in gastric and colorectal cancer (46,47)), we decided to investigate serum S100A4. All individuals enrolled into our study including all healthy controls and all IBD patients were investigated in the same manner.…”

Section: Discussionmentioning

confidence: 99%

S100A4 Protein in Inflammatory Bowel Disease: Results of a Single Centre Prospective Study

Morávková

Kohoutová

Vávrová

et al. 2017

Acta Med. (Hradec Kralove, Czech Repub.)

View full text Add to dashboard Cite

Results: Serum S100A4 was significantly higher in UC (158.6 ± 56.2 ng/mL), p = 0.019 and in CD (154.4 ± 52.1 ng/mL), p = 0.007 compared to controls (104.8 ± 40.5 ng/mL). No difference in S100A4 was revealed between UC and CD, p > 0.05. Serum S100A4 in each CD subgroup (according to behaviour) was significantly higher compared to controls, p < 0.05. Serum S100A4 was significantly higher in L2 (144.6 ± 44.2 ng/mL), p = 0.041 and in L3 (163.0 ± 52.8 ng/mL), p = 0.002 compared to controls and in L3 compared to L1 (126.9 ± 47.6 ng/mL), p = 0.017. Conclusion: Association of serum S100A4 protein with UC and CD was confirmed. In CD, disease behaviour did not influence serum concentration of S100A4 protein. In CD, higher levels of serum S100A4 were observed in patients with ileo-colonic and colonic involvement compared to those with isolated small bowel involvement. K E Y WO R D S S100A4 protein; inflammatory bowel disease; ulcerative colitis; Crohn's disease

show abstract

S100A4 promotes liver fibrosis via activation of hepatic stellate cells

Cited by 129 publications

References 32 publications

S100A4 promotes colon inflammation and colitis-associated colon tumorigenesis

S100A4 promotes colon inflammation and colitis-associated colon tumorigenesis

Xiayuxue decoction reduces renal injury by promoting macrophage apoptosis in hepatic cirrhotic rats

S100A4 Protein in Inflammatory Bowel Disease: Results of a Single Centre Prospective Study

Contact Info

Product

Resources

About