S100A4 plays a key role in TRPV3 ion channel expression and its electrophysiological function

Deng, Simin; Liao, Ziling; Huang, Jufang; Huang, Rongqi; Li, Zhiyuan

doi:10.1016/j.neulet.2021.135999

Cited by 4 publications

(3 citation statements)

References 38 publications

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“…For instance, in a study performed by Deng and coworkers, it has been shown that the TRPV3 channel as a common ion channel involved in the regulation of crucial neurons in the spinal cord or brain pain pathway ( Liu et al, 2011 ) could interact with S100A4 ( Deng et al, 2021 ). This interaction enhances TRPV3 functions on ion flux regulation ( Deng et al, 2021 ) and links the Ca 2+ binding protein (S100A4) and the TRPV3 ion channel. Given that, this finding suggests that the TRPV3 regulatory mechanism might have significant therapeutic and diagnostic implications in TRPV3/Ca 2+ -associated diseases ( Deng et al, 2021 ).…”

Section: Role Of Trp Channels In Health and Disease Conditionsmentioning

confidence: 99%

“…This interaction enhances TRPV3 functions on ion flux regulation ( Deng et al, 2021 ) and links the Ca 2+ binding protein (S100A4) and the TRPV3 ion channel. Given that, this finding suggests that the TRPV3 regulatory mechanism might have significant therapeutic and diagnostic implications in TRPV3/Ca 2+ -associated diseases ( Deng et al, 2021 ). In a different study performed in animal models, it has been shown that a vesicular trafficking protein known as SNX11 in response to temperature changes modulates mouse behavior ( Huang et al, 2020 ).…”

Section: Role Of Trp Channels In Health and Disease Conditionsmentioning

confidence: 99%

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A Review on the Role of TRP Channels and Their Potential as Drug Targets_An Insight Into the TRP Channel Drug Discovery Methodologies

Fallah¹,

Ahuja²,

Lin³

et al. 2022

Front. Pharmacol.

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Transient receptor potential (TRP) proteins are a large group of ion channels that control many physiological functions in our body. These channels are considered potential therapeutic drug targets for various diseases such as neurological disorders, cancers, cardiovascular disease, and many more. The Nobel Prize in Physiology/Medicine in the year 2021 was awarded to two scientists for the discovery of TRP and PIEZO ion channels. Improving our knowledge of technologies for their study is essential. In the present study, we reviewed the role of TRP channel types in the control of normal physiological functions as well as disease conditions. Also, we discussed the current and novel technologies that can be used to study these channels successfully. As such, Flux assays for detecting ionic flux through ion channels are among the core and widely used tools for screening drug compounds. Technologies based on these assays are available in fully automated high throughput set-ups and help detect changes in radiolabeled or non-radiolabeled ionic flux. Aurora’s Ion Channel Reader (ICR), which works based on label-free technology of flux assay, offers sensitive, accurate, and reproducible measurements to perform drug ranking matching with patch-clamp (gold standard) data. The non-radiolabeled trace-based flux assay coupled with the ICR detects changes in various ion types, including potassium, calcium, sodium, and chloride channels, by using appropriate tracer ions. This technology is now considered one of the very successful approaches for analyzing ion channel activity in modern drug discovery. It could be a successful approach for studying various ion channels and transporters, including the different members of the TRP family of ion channels.

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Section: Role Of Trp Channels In Health and Disease Conditionsmentioning

confidence: 99%

Section: Role Of Trp Channels In Health and Disease Conditionsmentioning

confidence: 99%

A Review on the Role of TRP Channels and Their Potential as Drug Targets_An Insight Into the TRP Channel Drug Discovery Methodologies

Fallah¹,

Ahuja²,

Lin³

et al. 2022

Front. Pharmacol.

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“…TRPV3 is activated in the temperature range from 34°C to 38°C and is involved in a variety of physiological processes, such as temperature perception, nociception, pruritus, and wound healing ( Kochukov et al, 2006 ; Neuberger et al, 2021a ). Deng et al found that S100A4 (S100 calcium-binding protein family) interacts with the TRPV3 channel protein, thereby significantly enhancing the latter’s ability to regulate calcium ions, with implications for the treatment of neurological diseases ( Deng et al, 2021 ).…”

Section: Transient Receptor Potential Channelsmentioning

confidence: 99%

Regulation of transient receptor potential channels by traditional Chinese medicines and their active ingredients

et al. 2022

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In recent years, activation of thermal transient receptor potential (TRP) ion channels at a range of temperatures has received widespread attention as a target for traditional Chinese medicine (TCM) to regulate body temperature and relieve pain. Discovery of transient receptor potential vanilloid 1 (TRPV1) was awarded a Nobel Prize, reflecting the importance of these channels. Here, the regulatory effects of TCMs and their active ingredients on TRP ion channels are reviewed, and future directions for research on the cold, hot, warm, cool, and neutral natures of TCMs are considered. In herbs with cold, hot, warm, cool, and neutral natures, we found 29 TCMs with regulatory effects on TRP ion channels, including Cinnamomi Cortex, Capsici Fructus, Rhei Radix et Rhizoma, Macleayae cordatae Herba, Menthae Haplocalycis Herba, and Rhodiolae Crenulatae Radix et Rhizoma. Although some progress has been made in understanding the regulation of TRP ion channels by TCMs and their ingredients, the molecular mechanism by which TCMs have this effect remains to be further studied. We hope this review will provide a reference for further research on the cold, hot, warm, cool, and neutral natures of TCMs.

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Upregulation of hypothalamic TRPV4 via S100a4/AMPKα signaling pathway promotes the development of diet-induced obesity

Xi,

Zhu,

Zhang

et al. 2024

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

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S100A4 plays a key role in TRPV3 ion channel expression and its electrophysiological function

Cited by 4 publications

References 38 publications

A Review on the Role of TRP Channels and Their Potential as Drug Targets_An Insight Into the TRP Channel Drug Discovery Methodologies

A Review on the Role of TRP Channels and Their Potential as Drug Targets_An Insight Into the TRP Channel Drug Discovery Methodologies

Regulation of transient receptor potential channels by traditional Chinese medicines and their active ingredients

Upregulation of hypothalamic TRPV4 via S100a4/AMPKα signaling pathway promotes the development of diet-induced obesity

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