S100A12 (EN-RAGE) in monitoring Kawasaki disease

MicroRNA-93 may control vascular endothelial growth factor A in circulating peripheral blood mononuclear cells in acute Kawasaki disease

“…Binding of ligand to Toll-like receptor 4 leads to activation of NF-κB and induces expression of many proinflammatory cytokines. The serum concentration of receptor for advanced glycation end products may be associated with reactivity to IVIG (23,28,29). Our study showed that miR-150 may play a significant role regulating NF-κB-related inflammation in acute KD.…”

“…MiR-150 is reported to control inflammation through NF-κB signaling by acting on IRAK3, MAPK, SGCZ, C10ORF14, and ACCN2 resulting in negative feedback signaling (9,16). We have previously studied that coronary arteritis in KD patients and the roles of proteins such as VEGF-A, the S100 protein family, and inducible nitric oxide synthase (3,(17)(18)(19)(20)(21)(22)(23)(24). Myeloid-related protein8 (also known as S100 calcium-binding protein A8), Myeloid-related protein14 (S100 calcium-binding protein A9), and S100 calcium-binding protein A12 are DamageAssociated Molecular Pattern molecules, which are associated The expression of SGCZ, EIF4G3, PBX3, ANO4, FAM129B, and LIMCh1 were up-regulated and MAPKBP1, AUTS2, DEPDC1 and hIVEP3 were down-regulated: these are associated with coronary artery disease.…”

“…WASP, TEC, PKC, ITGB1 and CD44 were up-regulated, and PI3 was down-regulated: these have a role in leukocyte rolling and docking on the endothelial surface of capillaries, or leukocyte transmigration through capillary endothelial layer. (23)(24)(25)(26)(27)(28)(29). Myeloid-related protein8/ Myeloid-related protein14 hetero-dimmers are released in high concentrations at local sites of inflammation and have been described as one of the endogenous ligands of Toll-like receptor 4.…”

Monitoring neutrophil activation in juvenile rheumatoid arthritis by S100A12 serum concentrations

“…Serum concentrations of S100A12 are elevated in patients with these autoimmune diseases. Furthermore, S100A12 serum levels are useful indicators of disease activity in patients with Kawasaki disease (28).…”

Enhancing translational research in paediatric rheumatology through standardization

“…39 Serum S100A8/9 measured before starting treatment with MTX has also been shown to have value in predicting good response to this first line DMARD in JIA, 45 and decrease in S100A12 was associated with response to IVIG therapy in children with Kawasaki Disease, a multisystem vasculitis affecting young children. 46 The search for predictive biomarkers with better sensitivity and specificity to guide treatment is ongoing: some early results are promising. 47 An exciting development in systemic JIA, is a study showing that a panel of urine peptide biomarkers can discriminate between active and quiescent disease, if validated and shown to have predictive value this approach would have considerable benefit since it could be adapted to non-invasive testing.…”