S0635 A Comparative Study of the Efficacy of Endoscopic Injection of Cyanoacrylate Glue vs Other Interventional Modalities for Treatment of Acute Gastric Variceal Bleeding: A Systematic Review and Meta-Analysis

Rozenshteyn, Frederick; Herman, Michael V.; Collins, Kelsey; Martinez, Isabel Guerrido; Valentin, Nelson; Shah, Michelle; Weisberg, Ilan

doi:10.14309/01.ajg.0000704588.29178.a7

Cited by 1 publication

(1 citation statement)

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“…n-Butyl cyanoacrylates (n-BCAs) are used in cyanoacrylate adhesive closure (CAC) procedures to treat superficial veins, in interventional radiology to treat vascular anomalies and in gastric surgery to treat gastric varices. [1][2][3][4][5] There have been significant developments and advancements in the Interventional Neuroradiology (INR) speciality over the past five decades. Kerber et al were the first to describe super-selective embolisation of intracranial vascular anomalies using a novel method involving isobutyl cyanoacrylate and a calibrated leak balloon system as early as 1978, 6 and Professor Kerber was the first to perform a carotid angioplasty in 1979.…”

Section: Introductionmentioning

confidence: 99%

Polymerisation of cyanoacrylates: The effect of sclero-embolic and contrast agents

Gracé,

Connor,

Bester

et al. 2023

Phlebology

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Objectives The objective is to investigate the interaction of sclero-embolic and contrast agents with the polymerisation of medical grade n-butyl-cyanoacrylates. Methods An in vitro spectrophotometric absorbance method was developed to detect changes in light transmission to measure n-BCA polymerisation. The initiation and the rate-of-polymerisation of mixtures of n-BCA with sclero-embolic and contrast agents were investigated. Results Initiation of polymerisation: VENABLOCK™ and HISTOACRYL® were the fastest agents to polymerise, while VENASEAL™ was the slowest. Rate of polymerisation: Hypertonic saline inhibited the polymerisation of all n-BCAs, while hypertonic glucose prolonged the polymerisation rate. ETHANOL and detergent sclerosants had no effect. Contrast agents OMNIPAQUE™ and ULTRAVIST® initiated and prolonged the polymerisation of n-BCA, but in contrast, LIPIODOL® failed to initiate the process. Conclusions The commercially available medical cyanoacrylates differ in their polymerisation rates. These polymerisation rates are further affected when these products are used in conjunction with other compounds, such as sclero-embolic and contrast agents.

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