S0057 Gender Differences in Outcomes in Patients With Pancreatitis: A Contemporary Analysis

Albeiruti, Ridwaan; Chaudhary, Fahad

doi:10.14309/01.ajg.0000702276.69471.c5

Cited by 2 publications

(1 citation statement)

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“…Numerous etiologies of AP and CP have been described, as shown in Table 1 , while the impacts of sex are still actively being investigated [ 5 , 6 ]. In 2016, there were nearly 520,000 AP and CP hospitalizations in the United States, with 48% being female [ 7 , 8 ]. Although the incidence of AP is similar among males and females, male sex is associated with higher mortality [ 9 ].…”

Section: Sex Differences In Pancreatitismentioning

confidence: 99%

Sex-Related Differences of Acute and Chronic Pancreatitis in Adults

Drake

Dodwad

Davis

et al. 2021

JCM

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The incidence of acute and chronic pancreatitis is increasing in the United States. Rates of acute pancreatitis (AP) are similar in both sexes, but chronic pancreatitis (CP) is more common in males. When stratified by etiology, women have higher rates of gallstone AP, while men have higher rates of alcohol- and tobacco-related AP and CP, hypercalcemic AP, hypertriglyceridemic AP, malignancy-related AP, and type 1 autoimmune pancreatitis (AIP). No significant sex-related differences have been reported in medication-induced AP or type 2 AIP. Whether post-endoscopic retrograde cholangiopancreatography pancreatitis is sex-associated remains controversial. Animal models have demonstrated sex-related differences in the rates of induction and severity of AP, CP, and AIP. Animal and human studies have suggested that a combination of risk factor profiles, as well as genes, may be responsible for the observed differences. More investigation into the sex-related differences of AP and CP is desired in order to improve clinical management by developing effective prevention strategies, diagnostics, and therapeutics.

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