“…CAID experiments provide invaluable insights into the performance of the current predictors of disorder and disorder functions [ 31 , 33 ]. They were recently used to identify accurate and practical methods for the prediction of disorder and disordered binding regions [ 62 ], analyze the performance of predictors that apply deep learning [ 58 ], investigate the use of AlphaFold for the disorder prediction [ 60 , 63 , 64 ], and design new methods for protein structure and disorder function predictions [ 47 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 ]. CAID2 featured the first evaluation of predictions of DLs [ 33 ].…”