S‐Nitrosoglutathione Decreases Inflammation and Bone Resorption in Experimental Periodontitis in Rats

Menezes, Adriana Magalhães Andrade de; Souza, Gabriela Freitas Pereira de; Gomes, Antoniella S.; Leitão, Renata Ferreira de Carvalho; Ribeiro, Ronaldo de Albuquerque; Oliveira, Marcelo Ganzarolli de; Brito, Gerly Anne de Castro

doi:10.1902/jop.2011.110332

Cited by 27 publications

(23 citation statements)

References 35 publications

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“…There has been an increase in the use of animal models in drug‐screening studies for the prevention and treatment of bone diseases, such as osteoporosis and periodontal disease. The ligature‐induced periodontitis model has been used extensively as a highly reproducible model that evaluates the progression of periodontal disease 14,18,22 . Some studies have demonstrated that this ligature model favors a heavier proinflammatory and proresorptive response, as demonstrated by increased IL‐1β/IL‐1ra, IL‐6/IL‐10, and RANKL/OPG ratios in the gingival tissues harvested from ligated sites versus non‐ligated sites 24 …”

Section: Discussionmentioning

confidence: 99%

“…Nitric oxide (NO) is an important mediator of periodontal disease, and inflammatory cytokines stimulate the expression of inducible NO synthase (iNOS), causing NO production. The NO formation in gingival tissues previously collected and stored at −80°C, in rats receiving 3, 10, or 30 mg/kg simvastatin or saline orally, was investigated at day 11 after periodontitis induction indirectly using the Griess reaction method to measure total nitrate and nitrite levels 22 . Nitrate/nitrite (NOX) levels were expressed as micromolar per milligram tissue.…”

Section: Methodsmentioning

confidence: 99%

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Protective Mechanisms of Simvastatin in Experimental Periodontal Disease

Dalcico

Menezes

Deocleciano

et al. 2013

Journal of Periodontology

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Protective Mechanisms of Simvastatin in Experimental Periodontal Disease

Dalcico

Menezes

Deocleciano

et al. 2013

Journal of Periodontology

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“…Aso, S-nitrosoglutathione is a nitric oxide donor that seems to exert antioxidant, anti-inflammatory, and microbicidal actions, and has been demonstrated as a potential drug for the topical treatment of periodontitis [40]. Finally, because of its anti-inflammatory effects, a novel α-iso-cubebenol isolated from the dried fruit of S. chinensis is considered a novel therapeutic agent to ameliorate periodontitis [41].…”

Section: Oxidative Stress and Metabolic Syndromementioning

confidence: 99%

Periodontal disease: the influence of metabolic syndrome

et al. 2012

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Metabolic syndrome (MetS) is a cluster of cardiovascular risk factors that include obesity, impaired glucose tolerance or diabetes, hyperinsulinemia, hypertension, and dyslipidemia. Recently, more attention has been reserved to the correlation between periodontitis and systemic health. MetS is characterized by oxidative stress, a condition in which the equilibrium between the production and the inactivation of reactive oxygen species (ROS) becomes disrupted. ROS have an essential role in a variety of physiological systems, but under a condition of oxidative stress, they contribute to cellular dysfunction and damage. Oxidative stress may act as a common link to explain the relationship between each component of MetS and periodontitis. All those conditions show increased serum levels of products derived from oxidative damage, promoting a proinflammatory state. Moreover, adipocytokines, produced by the fat cells of fat tissue, might modulate the balance between oxidant and antioxidant activities. An increased caloric intake involves a higher metabolic activity, which results in an increased production of ROS, inducing insulin resistance. At the same time, obese patients require more insulin to maintain blood glucose homeostasis – a state known as hyperinsulinemia, a condition that can evolve into type 2 diabetes. Oxidation products can increase neutrophil adhesion and chemotaxis, thus favoring oxidative damage. Hyperglycemia and an oxidizing state promote the genesis of advanced glycation end-products, which could also be implicated in the degeneration and damage of periodontal tissue. Thus, MetS, the whole of interconnected factors, presents systemic and local manifestations, such as cardiovascular disease and periodontitis, related by a common factor known as oxidative stress.

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“…[23242526] Experimental animal models are used to evaluate the etiopathogenesis, clinical characteristics, and histological and immunologic aspects of periodontal disease. [2728293031]…”

Section: Various Animal Models Usedmentioning

confidence: 99%

Ethical guidelines, animal profile, various animal models used in periodontal research with alternatives and future perspectives

Pasupuleti¹,

Shetty²,

Salwaji³

2016

J Indian Soc Periodontol

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Laboratory animal models serve as a facilitator to investigate the etiopathogenesis of periodontal disease, are used to know the efficacy of reconstructive and regenerative procedures, and are also helpful in evaluation of newer therapeutic techniques including laser and implant therapies prior to application in the human beings. The aim of this review is to know the different animal models used in various specialties of dental research and to know the ethical guidelines prior to the usage of experimental models with main emphasis on how to refine, replace, and reduce the number of animal models usage in the laboratory. An online search for experimental animal models used in dental research was performed using MEDLINE/PubMed database. Publications from 2009 to May 2013 in the specialty of periodontics were included in writing this review. A total of 652 references were published in PubMed/MEDLINE databases based on the search terms used. Out of 245 studies, 241 were related to the periodontal research published in English from 2009 to 2013. Relevant papers were chosen according to the inclusion and exclusion criteria. After extensive electronic and hand search on animal models, it has been observed that various animal models were used in dental research. Search on animal models used for dental research purpose revealed that various animals such as rats, mice, guinea pigs, rabbit, beagle dogs, goats, and nonhuman primates were extensively used. However, with the new advancement of ex vivo animal models, it has become easy to investigate disease pathogenesis and to test the efficacy of newer therapeutic modalities with the reduced usage of animal models. This review summarized the large amount of literature on animal models used in periodontal research with main emphasis on ethical guidelines and on reducing the animal model usage in future perspective.

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S‐Nitrosoglutathione Decreases Inflammation and Bone Resorption in Experimental Periodontitis in Rats

Abstract: Local intragingival injections of GSNO reduces inflammation and bone loss in experimental periodontal disease.

Cited by 27 publications

References 35 publications

Protective Mechanisms of Simvastatin in Experimental Periodontal Disease

Protective Mechanisms of Simvastatin in Experimental Periodontal Disease

Periodontal disease: the influence of metabolic syndrome

Ethical guidelines, animal profile, various animal models used in periodontal research with alternatives and future perspectives

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