2012
DOI: 10.1902/jop.2011.110332
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S‐Nitrosoglutathione Decreases Inflammation and Bone Resorption in Experimental Periodontitis in Rats

Abstract: Local intragingival injections of GSNO reduces inflammation and bone loss in experimental periodontal disease.

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Cited by 29 publications
(24 citation statements)
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“…There has been an increase in the use of animal models in drug‐screening studies for the prevention and treatment of bone diseases, such as osteoporosis and periodontal disease. The ligature‐induced periodontitis model has been used extensively as a highly reproducible model that evaluates the progression of periodontal disease 14,18,22 . Some studies have demonstrated that this ligature model favors a heavier proinflammatory and proresorptive response, as demonstrated by increased IL‐1β/IL‐1ra, IL‐6/IL‐10, and RANKL/OPG ratios in the gingival tissues harvested from ligated sites versus non‐ligated sites 24 …”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…There has been an increase in the use of animal models in drug‐screening studies for the prevention and treatment of bone diseases, such as osteoporosis and periodontal disease. The ligature‐induced periodontitis model has been used extensively as a highly reproducible model that evaluates the progression of periodontal disease 14,18,22 . Some studies have demonstrated that this ligature model favors a heavier proinflammatory and proresorptive response, as demonstrated by increased IL‐1β/IL‐1ra, IL‐6/IL‐10, and RANKL/OPG ratios in the gingival tissues harvested from ligated sites versus non‐ligated sites 24 …”
Section: Discussionmentioning
confidence: 99%
“…Nitric oxide (NO) is an important mediator of periodontal disease, and inflammatory cytokines stimulate the expression of inducible NO synthase (iNOS), causing NO production. The NO formation in gingival tissues previously collected and stored at −80°C, in rats receiving 3, 10, or 30 mg/kg simvastatin or saline orally, was investigated at day 11 after periodontitis induction indirectly using the Griess reaction method to measure total nitrate and nitrite levels 22 . Nitrate/nitrite (NOX) levels were expressed as micromolar per milligram tissue.…”
Section: Methodsmentioning
confidence: 99%
“…Aso, S-nitrosoglutathione is a nitric oxide donor that seems to exert antioxidant, anti-inflammatory, and microbicidal actions, and has been demonstrated as a potential drug for the topical treatment of periodontitis [40]. Finally, because of its anti-inflammatory effects, a novel α-iso-cubebenol isolated from the dried fruit of S. chinensis is considered a novel therapeutic agent to ameliorate periodontitis [41].…”
Section: Oxidative Stress and Metabolic Syndromementioning
confidence: 99%
“…[23242526] Experimental animal models are used to evaluate the etiopathogenesis, clinical characteristics, and histological and immunologic aspects of periodontal disease. [2728293031]…”
Section: Various Animal Models Usedmentioning
confidence: 99%