S-N-P Ring Systems

Baumann, Norbert; Fachmann, Hans-Jürgen; Heibel, Brigitte; Jäger, Susanne; Kubny, Alfons

doi:10.1007/978-3-662-06360-6_4

Cited by 5 publications

(5 citation statements)

References 31 publications

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“…It could be suggested that the favourable interactions reported herein could be a result of pharmacokinetic changes. However, an ele-vating effect of lithium on brain levels of the drugs could be ruled out as lithium does not effect the activity of the cytochrome enzymes involved in the metabolism of the compounds under investigation [46]. Studies in the learned helplessness model revealed the lithium treatment did reverse escape deficits in some studies [ 2 3 , 241, but not all 1251.…”

Section: Discussionmentioning

confidence: 99%

The effect of lithium administration in animal models of depression: a short review

Redrobe¹,

Bourin²

1999

Fundamemntal Clinical Pharma

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The aim of this short review was to collate the data involving the effects of lithium alone, or in combination, with antidepressant drugs in several animal models of depression. It has been shown that lithium administration reduced immobility in the mouse forced swimming test when given 30 min, but not 45 min, before testing. Further studies indicated that this activity was probably a result of an activity on serotonin (5-HT) 1A and 1B receptor subtypes. Lithium treatment has been shown to reverse helpless behaviour in the learned helplessness model of depression after chronic treatment (30 days), where lithium was administered in the drinking water. Further studies showed that acute (5 days) administration of lithium failed to reverse behavioural deficits. In the olfactory bulbectomised rat model of depression, several immunological and enzymatic functions have been shown to be altered and these changes are regularised by antidepressant treatment as well as lithium administration for 15 days. Hypokinesia (reduced locomotor activity) is a phenomenon observed following immobilisation stress in rats. This behavioural deficit was attenuated by lithium together with a wide range of antidepressant drugs used in the treatment of unipolar depression at non-stimulant doses. In addition, a single administration of lithium slightly inhibited midbrain raphe lesion-induced muricidal behaviour (25%); however, repeated treatment (5 days) significantly attenuated this behavioural deficit. Lithium treatment has also been shown to reverse behavioural and biochemical deficits induced by reserpine together with those induced by acute administration of single intracerebroventricular (i.c.v.) dose of the Na, K-ATPase-inhibiting compound, ouabain. Long-term studies of lithium augmentation have not been performed, so that no clear recommendations for the duration of this therapy can be made. The points raised in this short review endorse the commencement of such studies.

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Section: Discussionmentioning

confidence: 99%

The effect of lithium administration in animal models of depression: a short review

Redrobe¹,

Bourin²

1999

Fundamemntal Clinical Pharma

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“…Indeed, the WAA assembly contains the highest number of conserved single-copy Arthropoda genes of any published aphid genome (Figure 1c). A taxon-annotated GC content-coverage plot (known as a "BlobPlot"; Kumar, Jones, Koutsovoulos, Clarke, & Blaxter, 2013) revealed the co-assembly of the obligate aphid bacterial symbiont Buchnera aphidicola (Baumann et al, 1995;Douglas, 1998;Hansen & Moran, 2011;Shigenobu & Wilson, 2011) and a secondary symbiont, Serratia symbiotica (Burke & Moran, 2011;Manzano-Marín & Latorre, 2016;Moran, Russell, Koga, & Fukatsu, 2005) (Supplementary Figure 1). These bacterial scaffolds were filtered from the final assembly, along with scaffolds showing atypical GC content and read coverage, leaving the final assembly free from obvious contamination (Supplementary Figure 2).…”

Section: Genome Sequencing and Assemblymentioning

confidence: 99%

A chromosome-level genome assembly of the woolly apple aphid,Eriosoma lanigerum(Hausmann) (Hemiptera: Aphididae)

Biello

Archana

Godfrey

et al. 2020

Preprint

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Woolly apple aphid (WAA, Eriosoma lanigerum Hausmann) (Hemiptera: Aphididae), is a major pest of apple trees (Malus domestica, order Rosales) and is critical to the economics of the apple industry in most parts of the world. Here, we generated a chromosome-level genome assembly of WAA -representing the first genome sequence from the aphid subfamily Eriosomatinae -using a combination of 10X Genomics linked-reads and in vivo Hi-C data.The final genome assembly is 327 Mb, with 91% of the assembled sequences anchored into six chromosomes. The contig and scaffold N50 values are 158 kb and 71 Mb, respectively, and we predicted a total of 28,186 protein-coding genes. The assembly is highly complete, including 97% of conserved arthropod single-copy orthologues based on BUSCO analysis.Phylogenomic analysis of WAA and nine previously published aphid genomes, spanning four aphid tribes and three subfamilies, reveals that the tribe Eriosomatini (represented by WAA) is recovered as a sister group to Aphidini + Macrosiphini (subfamily Aphidinae). We identified syntenic blocks of genes between our WAA assembly and the genomes of other aphid species and find that two WAA chromosomes (El5 and El6) map to the conserved Macrosiphini and Aphidini X chromosome. Our high-quality WAA genome assembly and annotation provides a valuable resource for research in a broad range of areas such as comparative and population genomics, insect-plant interactions and pest resistance management.

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“…[50,51] Up to now, several studies have been reported that hyphenate various high-throughput lab automation devices and MBR systems to obtain such data densities that enable almost holistic strain and bioprocess development. [40,[52][53][54][55][56] In the past, the integration of robotic systems for downstream process development led to significant increases in the throughput of several standard operation procedures. For example, cell lysis has been optimized for improved release of intracellular products, [57,58] the screening of chromatographic material and binding/elution conditions was facilitated, [59] and the identification of optimal compositions of aqueous two-phase systems [60] or precipitation conditions [61] has become experimentally feasible.…”

Section: Integration Of Mbr Systems Into Lab Roboticsmentioning

confidence: 99%

“…So far only a few but highly interesting studies have been reported that combine high-throughput upstream and downstream bioprocess development. [54,55,62] This is certainly due to the much higher complexity of such holistic approaches. For further information on recent developments in high-throughput downstream processing the reader is referred to the following reviews.…”

Section: Integration Of Mbr Systems Into Lab Roboticsmentioning

confidence: 99%

Microbioreactor Systems for Accelerated Bioprocess Development

Hemmerich

Noack

Wiechert

et al. 2018

Biotechnology Journal

135

143

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In recent years, microbioreactor (MBR) systems have evolved towards versatile bioprocess engineering tools. They provide a unique solution to combine higher experimental throughput with extensive bioprocess monitoring and control, which is indispensable to develop economically and ecologically competitive bioproduction processes. MBR systems are based either on down-scaled stirred tank reactors or on advanced shaken microtiter plate cultivation devices. Importantly, MBR systems make use of optical measurements for non-invasive, online monitoring of important process variables like biomass concentration, dissolved oxygen, pH, and fluorescence. The application range of MBR systems can be further increased by integration into liquid handling robots, enabling automatization and, thus standardization, of various handling and operation procedures. Finally, the tight integration of quantitative strain phenotyping with bioprocess development under industrially relevant conditions greatly increases the probability of finding the right combination of producer strain and bioprocess control strategy. This review will discuss the current state of the art in the field of MBR systems and we can readily conclude that their importance for industrial biotechnology will further increase in the near future.

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S-N-P Ring Systems

Cited by 5 publications

References 31 publications

The effect of lithium administration in animal models of depression: a short review

The effect of lithium administration in animal models of depression: a short review

A chromosome-level genome assembly of the woolly apple aphid,Eriosoma lanigerum(Hausmann) (Hemiptera: Aphididae)

Microbioreactor Systems for Accelerated Bioprocess Development

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