S-limonene protects the heart in an experimental model of myocardial infarction induced by isoproterenol: Possible involvement of mitochondrial reactive oxygen species

Rhana, Paula; Barros, Guilherme Mendes; Santos, Vinícius Cisneiros de Oliveira; Costa, Alexandre Dantas; Santos, Danillo Menezes dos; Fernandes‐Braga, Weslley; Durço, Aimée Obolari; Santos, Márcio Roberto Viana dos; Roman‐Campos, Danilo; Vasconcelos, Carla Maria Lins de; Cruz, Jáder Santos; Souza, Diego Santos

doi:10.1016/j.ejphar.2022.175134

Cited by 10 publications

(2 citation statements)

References 35 publications

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“…Studies have found that S-adenosylmethionine, as a methyl donor, mediates epigenetic effects to regulate the autophagy process ( Ouyang et al, 2020 ), preventing the autophagy of Tibetan sheep in the plateau environment. In limonene and pinene degradation, related to oxidative stress and heart protection metabolites ( Rhana et al, 2022 ) (S) - Limonene is higher were increased in lambs, and have anti-inflammatory, antioxidant ( Pina et al, 2022 ) of the Carvone is also increased in lambs. In 1.5 Y_vs_3.5 Y, sirolimus up-regulated at the adult stage was enriched in cellular senescence and had antifungal, anti-proliferation and immunosuppressive activities ( Sehgal, 2003 ), indicating that adult sheep had stronger adaptability to plateau.…”

Section: Discussionmentioning

confidence: 99%

Multi-omics revealed rumen microbiota metabolism and host immune regulation in Tibetan sheep of different ages

Sha,

Liu,

et al. 2024

Front. Microbiol.

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The rumen microbiota and metabolites play an important role in energy metabolism and immune regulation of the host. However, the regulatory mechanism of rumen microbiota and metabolite interactions with host on Tibetan sheep’s plateau adaptability is still unclear. We analyzed the ruminal microbiome and metabolome, host transcriptome and serum metabolome characteristics of Tibetan sheep at different ages. Biomarkers Butyrivibrio, Lachnospiraceae_XPB1014_group, Prevotella, and Rikenellaceae_RC9_gut_group were found in 4 months, 1.5 years, 3.5 years, and 6 years Tibetan sheep, respectively. The rumen microbial metabolites were mainly enriched in galactose metabolism, unsaturated fatty acid biosynthesis and fatty acid degradation pathways, and had significant correlation with microbiota. These metabolites further interact with mRNA, and are co-enriched in arginine and proline metabolism, metabolism of xenobiotics by cytochrome P450, propanoate metabolism, starch and sucrose metabolism, gap junction pathway. Meanwhile, serum metabolites also have a similar function, such as chemical carcinogenesis − reactive oxygen species, limonene and pinene degradation, and cutin, suberine and wax biosynthesis, thus participating in the regulation of the body’s immune and energy-related metabolic processes. This study systematically revealed that rumen microbiota, metabolites, mRNA and serum metabolites of Tibetan sheep were involved in the regulation of fermentation metabolic function and immune level of Tibetan sheep at different ages, which provided a new perspective for plateau adaptability research of Tibetan sheep at different ages.

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Section: Discussionmentioning

confidence: 99%

Multi-omics revealed rumen microbiota metabolism and host immune regulation in Tibetan sheep of different ages

Sha,

Liu,

et al. 2024

Front. Microbiol.

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“…The antioxidant and anti-inflammatory properties of these compounds have been previously evidenced by their ability to modulate signaling pathways such as those involving nitric oxide (NO) synthesis or nuclear factor kappa-light-chain-enhancer of activated B cells (NF- κ B), with related downregulation of proinflammatory cytokines [ 3 , 4 , 5 ]. The antioxidant and anti-inflammatory properties of these compounds can contribute to their beneficial effects against intestinal diseases at the level of mucosal barrier or microbiota ecology [ 6 , 7 , 8 ], but also against ischemic phenomena of the heart [ 9 , 10 , 11 ], or against neurodegeneration [ 4 , 12 , 13 ]. Taking into account the significant therapeutic opportunities that these compounds can offer in the human body, first of all, we investigated their concentration profiles during their time in the bloodstream and in the central nervous system (CNS) of rats, after intravenous and oral administration.…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetic and Permeation Studies in Rat Brain of Natural Compounds Led to Investigate Eugenol as Direct Activator of Dopamine Release in PC12 Cells

Pavan

Bianchi

Botti

et al. 2023

IJMS

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Eugenol, cinnamaldehyde and D-limonene, the main components of natural essential oils, are endowed with antioxidant and anti-inflammatory properties which allow them to induce beneficial effects on intestinal, cardiac and neuronal levels. In order to characterize their pharmacokinetic profiles and aptitude to permeate in the central nervous system after intravenous and oral administration to rats, new analytical procedures, easily achievable with HPLC-UV techniques, were developed. The terminal half-lives of these compounds range from 12.4 ± 0.9 (D-limonene) and 23.1 ± 1.6 min (cinnamaldehyde); their oral bioavailability appears relatively poor, ranging from 4.25 ± 0.11% (eugenol) to 7.33 ± 0.37% (cinnamaldehyde). Eugenol evidences a marked aptitude to permeate in the cerebrospinal fluid (CSF) of rats following both intravenous and oral administrations, whereas cinnamaldehyde appears able to reach the CSF only after intravenous administration; limonene is totally unable to permeate in the CSF. Eugenol was therefore recruited for in vitro studies of viability and time-/dose-dependent dopamine release in neuronal differentiated PC12 cells (a recognized cellular model mimicking dopaminergic neurons), evidencing its ability to increase cell viability and to induce dopamine release according to a U-shaped time-course curve. Moreover, concentration-response data suggest that eugenol may induce beneficial effects against Parkinson’s disease after oral administration.

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Cardioprotective Potential of Cymbopogon citratus Essential Oil against Isoproterenol-induced Cardiomyocyte Hypertrophy: Possible Involvement of NLRP3 Inflammasome and Oxidative Phosphorylation Complex Subunits

Ding,

Zhang,

Qiu

et al. 2024

CURR MED SCI

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S-limonene protects the heart in an experimental model of myocardial infarction induced by isoproterenol: Possible involvement of mitochondrial reactive oxygen species

Cited by 10 publications

References 35 publications

Multi-omics revealed rumen microbiota metabolism and host immune regulation in Tibetan sheep of different ages

Multi-omics revealed rumen microbiota metabolism and host immune regulation in Tibetan sheep of different ages

Pharmacokinetic and Permeation Studies in Rat Brain of Natural Compounds Led to Investigate Eugenol as Direct Activator of Dopamine Release in PC12 Cells

Cardioprotective Potential of Cymbopogon citratus Essential Oil against Isoproterenol-induced Cardiomyocyte Hypertrophy: Possible Involvement of NLRP3 Inflammasome and Oxidative Phosphorylation Complex Subunits

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