S. K. Jain, 1999 Distinguished economic botanist

Jain, S. K.

doi:10.1007/bf02907813

Cited by 17 publications

(24 citation statements)

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“…The mode of parthenolide activity comprises the inhibition of prostaglandin production [8] and 5-hydroxytryptamine secretion [9] as mediators of inflammation. Besides, parthenolide was shown to suppress phorbol-induced mouse ear and carrageenan-induced rat paw edema, inhibiting the platelet activation [10,11] and impairing the activity of the transcriptional factor NF-kB [12,13]. Herrera et al reported a strong intracellular antioxidant activity of this sesquiterpene lactone in hippocampal HT22 cells [14].…”

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confidence: 96%

Comparative analysis of parthenolide content in Tanacetum larvatum, an endemic species of Montenegro, collected from three different locations

et al. 2010

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Plants from the genus Tanacetum L. (Asteraceae) have been used in traditional medicine from ancient times, of which Tanacetum parthenium (L.) Shultz-Bip. (feverfew) has been known as a remedy for the treatment of various diseases, including migraine, arthritis, fever, vertigo, menstrual disorders, stomach-ache, and psoriasis [1]. Additionally, T. vulgare L. (common tansy) and T. microphyllum DC. are useful in the treatment of various inflammatory disorders [2,3]. Recent investigation of T. larvatum extract suggested the application of this species as an alternative or supplementary herbal remedy for the treatment of inflammatory diseases due to its anti-inflammatory and anti-ulcer activities [4]. The secondary metabolites that mediate these pharmacological effects are mainly biologically active sesquiterpene lactones, such as parthenolide and hydroxyachillin. Parthenolide, found in significant amounts in feverfew, has been indirectly linked to the anti-migraine action of feverfew preparations [5], as well as to anti-tumor and anti-inflammatory properties [6,7]. The mode of parthenolide activity comprises the inhibition of prostaglandin production [8] and 5-hydroxytryptamine secretion [9] as mediators of inflammation. Besides, parthenolide was shown to suppress phorbol-induced mouse ear and carrageenan-induced rat paw edema, inhibiting the platelet activation [10,11] and impairing the activity of the transcriptional factor NF-kB [12,13]. Herrera et al. reported a strong intracellular antioxidant activity of this sesquiterpene lactone in hippocampal HT22 cells [14]. As Miglietta et al. showed that parthenolide exerted in vitro stimulatory activity on tubulin assembly, the tubulin/microtubule system may represent a novel molecular target to be utilized in developing new combinational anticancer strategies [15]. Recent investigation, confirmed its gastric anti-ulcer properties due to its ability to restore the reduction of sulfhydryl groups within the gastric mucosa and to increase mucosal PGE 2 level [3,16].Feverfew from Serbia, as previously reported, does not contain parthenolide [17]. Because of the assumed importance of parthenolide content for pharmacological activities, supported by the studies already performed, we investigated the variation of parthenolide content in T. larvatum (Gris.) Kanitz. from Montenegro [18,19], during a five-year period. Collected materials from three different locations were subjected to quantitative 1 H NMR and HPLC analysis in order to get more insight whether the parthenolide content in the T. larvatum aerial parts is a stable property during five years period of investigation. We also measured the reduction of DPPH absorption by investigated T. larvatum extracts to indicate the capacity of the extracts to scavenge free radicals, independent of any enzymatic activity.Quantitative 1 H NMR and HPLC analysis revealed the parthenolide content (Table 1) in the aerial parts of T. larvatum, collected during the phase of flowering at three natural habitats in Montenegro, Komovi Mountain ...

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confidence: 96%

Comparative analysis of parthenolide content in Tanacetum larvatum, an endemic species of Montenegro, collected from three different locations

et al. 2010

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“…Keystone species are probably an inevitable result of ecological complexity [28] and in that sense their removal from an ecosystem can have highly nonlinear effects [66]. Such nonlinearity and the high-level patterns emerging from network dynamics are likely to decouple micro-from macroevolutionary processes.…”

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confidence: 99%

Modelling macroevolutionary patterns: An ecological perspective

Solé

Biological Evolution and Statistical Physics

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Abstract. Complex ecosystems display well-defined macroscopic regularities suggesting that some generic dynamical rules operate at the ecosystem level where the relevance of the single-species features is rather weak. Most evolutionary theory deals with genes/species as the units of selection operating on populations. However, the role of ecological networks and external perturbations seems to be at least as important as microevolutionary events based on natural selection operating at the smallest levels. Here we review some of the recent theoretical approximations to ecosystem evolution based on network dynamics. It is suggested that the evolutionary dynamics of ecological networks underlie fundamental laws of ecology-level dynamics which naturally decouple micro from macroevolutionary dynamics. Using simple models of macroevolution, most of the available statistical information obtained from the fossil record is remarkably well reproduced and explained within a new theoretical framework.

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“…Dimuon events are generated using the parton-level leading order (LO) Monte Carlo generator of Reference [39] and another LO MC generator used in [40,41]. The former MC includes the Standard Model (SM) DY contributions, Kaluza-Klein gravi-ton exchange contributions and their interference in dimuon production [39].…”

Section: Monte Carlo Studiesmentioning

confidence: 99%

“…For one-dimensional analyses in mass and cosθ * , the 95% confidence lower limit (CL) on the energy scale of compositeness Λ can be computed from equation 4.18 using the observed numbers of events (data distribution) in mass or cosθ * and the calculated cross sections for various Λ values (the same method as in [40,41,3]). …”

Section: Limit Calculation Of λmentioning

confidence: 99%

Search for Quark-Lepton Compositeness in the Dimuon Final State at DØ

Xuan

2005

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S. K. Jain, 1999 Distinguished economic botanist

Cited by 17 publications

References 0 publications

Comparative analysis of parthenolide content in Tanacetum larvatum, an endemic species of Montenegro, collected from three different locations

Comparative analysis of parthenolide content in Tanacetum larvatum, an endemic species of Montenegro, collected from three different locations

Modelling macroevolutionary patterns: An ecological perspective

Search for Quark-Lepton Compositeness in the Dimuon Final State at DØ

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