S-Coll2-1 and s-Coll2-1NO2 sont des marqueurs de la sévérité et de la progression de l’arthrose du genou : résultats de l’étude PRODIGE

Henrotin, Yves; Costes, Bruno; Malaise, Michel; Lœuille, Damien; Conrozier, Thierry; Maugars, Yves; Pelousse, F.; Lemaire, J. M.; Helleputte, T.; Tits, C.; Hick, Anne-Laure

doi:10.1016/j.rhum.2020.10.083

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“…More recently, a modified form of Coll2-1 has been introduced, known as Coll2-1NO 2 , which has a similar sequence but with a nitrated tyrosine residue at the position 4 of the sequence. Coll2-1NO 2 can be used as an indicator for inflammatory and oxidative/nitrative damage of the cartilage 17 . Since the recent researches on OA have shown a link the inflammatory events in the development and/or the progressiveness of the disease, Coll2-1NO 2 can give a better indication on the condition of OA.…”

Section: Introductionmentioning

confidence: 99%

Evaluating Coll2-1NO2 Level in Pre- and Post-menopausal Iraqi Women with Osteoarthritis

Ghanim,

Hasan

2024

Baghdad Sci.J

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Osteoarthritis (OA) is not an autoimmune but a chronic inflammatory disease affecting the joints of humans due to mechanical stress mostly in the knees and the hip. In OA a modification of the cartilage is encountered causing a pain in the joints upon movement. Coll2-1NO2 is a specific sequence of amino acids produced from the degradation of type II collagen, which is abundantly found in the cartilage, followed by a nitration in the tyrosine residue as a consequence of stress-inflammatory events. In this study, Coll2-1NO2 is used as a biomarker of OA to predict the inflammatory stress condition as well as the cartilage degradation in pre- and post-menopausal women. The results showed a significant increase of serum Coll2-1NO2 in pre- and post-menopausal women with OA compared to pre- and post-menopausal health women, at similar body mass index category (overweight). Pearson’s correlation analysis showed non-significant association between Coll2-1NO2 and other studied parameters. Moreover, ROC analysis showed a very excellent sensitivity of Coll2-1NO2 as a prognostic biomarker for OA disease in pre- and post-menopausal women

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Section: Introductionmentioning

confidence: 99%