S-allylmercapto-N-acetylcysteine up-regulates cellular glutathione and protects vascular endothelial cells from oxidative stress

Izigov, Nira; Farzam, Nahid; Savion, Naphtali

doi:10.1016/j.freeradbiomed.2011.01.028

Cited by 31 publications

(43 citation statements)

References 54 publications

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“…Such reaction happens when garlic cloves are crushed (Okada et al, 2005;Sela et al, 2008). The presence of allicin is easily detectable with its unique odor (Izigov et al, 2011) with about 4 -5 mg of allicin found in one clove of fresh garlic (Horev-Azaria et al, 2009).…”

Section: Chemical Propertiesmentioning

confidence: 99%

“…Allicin is a volatile oil found in garlic (Allium sativum L.) and other Allium species such as onion (Allium cepa L.) and shallot (Allium ascalonicum L.). It can rapidly pass through cell membranes and reach cellular compartments owing to its hydrophobic nature (Fujisawa et al, 2008a;Izigov et al, 2011;Sela et al, 2008). Allicin was found to disappear in a cell medium within a short period of time under in vitro conditions (Sela et al, 2008).…”

Section: Chemical Propertiesmentioning

confidence: 99%

“…Allicin was found to disappear in a cell medium within a short period of time under in vitro conditions (Sela et al, 2008). In addition, it is highly reactive (Fujisawa et al, 2008a) and readily binds to biological compounds containing the sulfhydryl group (Izigov et al, 2011;Sela et al, 2008). Interestingly, it may act as a pro-oxidant and rapidly oxidize thiol compounds that include glutathione and cystine (Okada et al, 2005).…”

Section: Chemical Propertiesmentioning

confidence: 99%

See 2 more Smart Citations

A Review of the Cardiovascular Benefits and Antioxidant Properties of Allicin

Chan

Yuen²,

Chan

et al. 2012

Phytotherapy Research

214

132

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Cardiovascular disease (CVD) is a category of chronic noncommunicable diseases causing high global mortality and has been a heavy social burden in many countries. In the search of chemicals that arise from natural food source, allicin is one such ingredient from garlic that was discovered with the potential to provide beneficial effects to the cardiovascular system. From the pharmacokinetic studies, allicin is known to be hydrophobic and can be readily absorbed through the cell membrane without inducing any damage to the phospholipid bilayer and then rapidly metabolized to exert pharmacological effects that are important to the cardiovascular system. It was found to provide cardio-protective effects by inducing vasorelaxation and alleviating various pathological conditions of CVD, including cardiac hypertrophy, angiogenesis, platelet aggregation, hyperlipidemia and hyperglycemia. Allicin was also discovered to further protect the cardiovascular system by enhancing the antioxidant status by lowering the level of reactive oxygen species and stimulating the production of glutathione. Other pharmacological benefits such as anticancer and antimicrobial activities were also discussed. It is concluded that allicin can be potentially developed into a health product for the cardiovascular system.

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Section: Chemical Propertiesmentioning

confidence: 99%

Section: Chemical Propertiesmentioning

confidence: 99%

Section: Chemical Propertiesmentioning

confidence: 99%

See 1 more Smart Citation

A Review of the Cardiovascular Benefits and Antioxidant Properties of Allicin

Chan

Yuen²,

Chan

et al. 2012

Phytotherapy Research

214

132

View full text Add to dashboard Cite

show abstract

“…The well-known protective effects of allicin against oxidative stress have been shown to target cardiovascular diseases, which are frequently correlated with oxidative stress (10,11). In addition, allicin exerts cardioprotective effects via activation of redox-sensitive transcription factors, including nuclear factor erythroid 2-related factor 2 (Nrf2) (12). Allicin has also been demonstrated to exert beneficial cardiovascular effects by preventing cardiac hypertrophy, hyperlipidemia and platelet aggregation (13).…”

Section: Introductionmentioning

confidence: 99%

Allicin attenuates H2O2-induced cytotoxicity in retinal pigmented epithelial cells by regulating the levels of reactive oxygen species

Zhang

Wei

et al. 2016

Molecular Medicine Reports

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Abstract.Retinal pigmented epithelial cell (RPE) oxidative stress is known to have a vital role in the etiology of age-related macular degeneration (AMD). The present study aimed to investigate whether allicin, a natural product with antioxidant activity, was able to protect RPEs (ARPE-19) from hydrogen peroxide (H 2 O 2 )-induced damage, and to determine the underlying mechanisms. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay was used to determine cellular viability, and reactive oxygen species (ROS) were detected using a ROS Assay kit. The results demonstrated that allicin was able to protect ARPE-19 cells from H 2 O 2 -induced damage in a dose-dependent manner. In addition, allicin attenuated oxidative stress by reducing the levels of intracellular ROS and malondialdehyde (MDA), and enhancing the glutathione/glutathione disulfide (GSSG) ratio. With regards to the underlying mechanism, allicin was able to markedly modulate the expression levels of ROS-associated enzymes, including superoxide dismutase, NADPH oxidase 4 and NAD(P)H dehydrogenase quinone 1, and elevate the activity of nuclear factor erythroid 2-related factor 2 in the H 2 O 2 -stimulated ARPE-19 cells. These results suggested that allicin may exert protective effects against H 2 O 2 -induced cytotoxicity in RPEs via ROS regulation.

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“…In pre-incubation experiments, in which cells are exposed to the toxic agent (tBHP) in fresh medium after removal of test compounds, it is expected that reduction of tBHP-induced damage will be due to cellular mediated effects, such as increased enzymatic (e.g. SOD) (Huang et al, 2006;Noh et al, 2010) and non-enzymatic cellular antioxidants, as glutathione (Alía et al, 2006;Izigov et al, 2011). Note that the extract and fraction, by themselves, had no effect on superoxide radical anion production (Fig.…”

Section: Measurement Of Superoxide Radical Scavenging Capacity Of Cormentioning

confidence: 99%

Cytoprotective effect of Coreopsis tinctoria extracts and flavonoids on tBHP and cytokine-induced cell injury in pancreatic MIN6 cells

Dias¹,

Liu²,

Jones³

et al. 2012

Journal of Ethnopharmacology

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S-allylmercapto-N-acetylcysteine up-regulates cellular glutathione and protects vascular endothelial cells from oxidative stress

Cited by 31 publications

References 54 publications

A Review of the Cardiovascular Benefits and Antioxidant Properties of Allicin

A Review of the Cardiovascular Benefits and Antioxidant Properties of Allicin

Allicin attenuates H2O2-induced cytotoxicity in retinal pigmented epithelial cells by regulating the levels of reactive oxygen species

Cytoprotective effect of Coreopsis tinctoria extracts and flavonoids on tBHP and cytokine-induced cell injury in pancreatic MIN6 cells

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