S-allylcysteine scavenges singlet oxygen and hypochlorous acid and protects LLC-PK1 cells of potassium dichromate-induced toxicity

Medina-Campos, Omar Noel; Barrera, Diana; Segoviano-Murillo, Sabina; Rocha, Diana; Maldonado, Perla D.; Mendoza-Patiño, Nicandro; Pedraza‐Chaverrí, José

doi:10.1016/j.fct.2007.05.002

Cited by 73 publications

(58 citation statements)

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“…-EDTA-H 2 O 2 -deoxyribose system [19]. The reaction mixture containing deoxyribose (0.056 mM), H 2 O 2 (1 mM), potassium phosphate buffer (10 mM, pH 7.4), FeCl 3 (0.2 mM), EDTA (0.2 mM), ascorbic acid (0.2 mM) and 100 lL of different concentrations of TPM (0, 1, 2, 4 and 7 mg/mL) was incubated in a water bath at 37 ± 0.5°C for 1 h. The extent of the deoxyribose degradation by the OHÁ formed was measured directly in the aqueous TPM phase by the thiobarbituric acid test at 532 nm.…”

Section: Ohá Scavenging Capacitymentioning

confidence: 99%

Antioxidant activity of topiramate: an antiepileptic agent

et al. 2012

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A number of experimental and clinical reports suggest the involvement of oxidative stress in pathophysiology of epilepsy. Topiramate, a new antiepileptic drug, induces antioxidant effect in epileptic animals. However, to date, no further studies appear to be carried out in order to demonstrate the ability of topiramate to act as antioxidant. Therefore, the objective of this work was to evaluate the in vitro superoxide (O₂(·-)), hydroxyl radical (OH·), hypochlorous acid (HOCl), hydrogen peroxide (H₂O₂), singlet oxygen ((1)O₂) and peroxynitrite (ONOO(-)) scavenging capacity of topiramate in comparison with reference compounds. In addition, we investigated the possible antitumour activity of this compound in some cancer cell lines. Topiramate displays a scavenging capacity compared to the reference compound, with the exception of ONOO(-), although it was less efficient than nordihydroguaiaretic acid, dimethylthiourea, ascorbic acid, sodium pyruvate and glutathione for O₂(·-), OH·, HOCl, H₂O₂ and (1)O₂(P < 0.0001), respectively, and not induced significant growth inhibition in cancer cell lines. The direct antioxidant properties of topiramate could explain the neuroprotective effects attributed to this compound and suggest its use as chemopreventive agent in a future.

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Section: Ohá Scavenging Capacitymentioning

confidence: 99%

Antioxidant activity of topiramate: an antiepileptic agent

et al. 2012

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“…It also increased manganese and copper/zinc superoxide dismutase activity and prevented behavioural changes. AGE, directly and indirectly, activates expression of important genes needed for neuronal survival [18,19]. Allyl-containing sulfides in garlic cause the upregulation of neuroprotective proteins such as mitochondrial uncoupling proteins.…”

Section: Allium Sativummentioning

confidence: 99%

Herbal Medicines as Neuroprotective Agent: A Mechanistic Approach

Roy

Awasthi

2017

Int J Pharm Pharm Sci

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Neurodegeneration refers to a condition of neuronal death occurring as a result of progressive disease of long-term and is becoming a major health problem in the 21st century. Neurons degenerated are not replaced resulting in a cognitive loss, many neurodegenerative disorders, such as schizophrenia, depression, Alzheimer's disease (AD), dementia, cerebrovascular impairment, seizure disorders, head injury, parkinsonism. The common pathology of neurodegeneration includes deposition of misfolded proteins such as amyloid-β (Aβ) in Alzheimer's disease, α-synuclein in Parkinson's disease (PD), transactive response DNA-binding protein 43 (TDP-43) in dementia. Neuroprotection refers to the strategies and possible mechanisms that are able to protect the central nervous system (CNS) against neuronal injury and neurodegenerative disorders. The past decade has witnessed an intense interest in herbal plants having long-term health-promoting or medicinal qualities. Comprehensive research and discovery have demonstrated that natural products, medicinal herbs, plant extracts, and their metabolites, have great potential as the neuroprotective agent. Although the precise mechanisms of action of herbal drugs have yet to be determined, some of them have been shown to prevent formation of betaamyloid plaques, promote nerve growth, some inhibit acetylcholinesterase (AChE) enzyme and malondialdehyde (MDA) formation in brain while other exhibits antioxidant activity by increasing the level of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx). Thus the herbal plants can be a valuable source of the drug against neurodegenerative disorders which will require high-throughput screening. This review will highlight the role of herbal plants and their phytoconstituents against neurodegenerative diseases and other related disorders, focusing on their mechanism of action and therapeutic potential.

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“…1). SAC exhibits antioxidant properties, including its capacity to scavenge superoxide radical (O 2˙-) [23,30,31] and to inhibit hydrogen peroxide (H 2 O 2 ) formation [7,21,30]. Through these properties, SAC has been shown to exert neuroprotective effects in different neurotoxic paradigms, including the reduction of the amyloid-beta peptideinduced oxidative damage, learning deficits [39], and apoptosis [37], while it exerted neurotrophic actions on cultured rat hippocampal neurons [36].…”

Section: Accepted Manuscriptmentioning

confidence: 99%