S‐allyl‐L‐cysteine protects hepatocytes from indomethacin‐induced apoptosis by attenuating endoplasmic reticulum stress

Chen, Peng; Chen, Chen; Hu, Mei Chen; Cui, Rui; Liu, Feng; Yu, Henghai; Ren, Yuling

doi:10.1002/2211-5463.12945

Cited by 8 publications

(2 citation statements)

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“…The accumulation of FC and oxLDLs in infiltrating macrophages within atheroma lesions triggers ER stress-induced apoptosis, which is mediated by CHOP and can be mitigated by antioxidants [ 31 ]. These results agree with the results of other studies revealing that 7-ketocholesterol leads to cell death via the IRE1 signaling pathway and dysregulation of calcium homeostasis [ 6 , 32 ]. S-allyl-L-cysteine, the main bioactive component of garlic, alleviates hepatocyte apoptosis by mitigating the expression of eIF2α and CHOP [ 33 ].…”

Section: Discussionsupporting

confidence: 93%

Diallyl disulfide alleviates hypercholesterolemia induced by a western diet by suppressing endoplasmic reticulum stress in apolipoprotein E-deficient mice

Kim¹

2023

BMC Complement Med Ther

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Background The endoplasmic reticulum (ER) plays a pivotal role in maintaining cellular metabolic homeostasis. ER stress refers to the accumulation of misfolded proteins, which can trigger an unfolded protein response for survival or death in the cells. Diallyl disulfide (DADS), a major active compound in garlic, has many health benefits for patients with metabolic diseases, especially cardiovascular or fatty liver diseases. However, its role in attenuating hypercholesterolemia by suppressing ER stress remains unknown. Therefore, in this study, we determined whether DADS supplementation could reduce ER stress in apolipoprotein E-deficient (ApoE−/−) mice fed a Western-type diet (WD). Methods ApoE−/− mice were fed either a WD alone or a WD supplemented with 0.1% DADS for 12 weeks (n = 10). Levels of plasma total cholesterol, triglyceride, leptin, and insulin were determined. Western blotting was performed to measure protein levels involved in ER stress markers. Histology and Immunostaining were performed on aortic root sections to confirm the effect of DADS on histology and expression of ER chaperone protein GRP78. Results The metabolic parameters showed that increases in fat weight, leptin resistance, and hypercholesterolemia were reversed in DADS-supplemented mice (p < 0.05). In addition, DADS ameliorated not only the protein of ER stress markers, phospho-eukaryotic initiation factor 2 subunit alpha and C/EBP homologous protein in the liver (p < 0.05) but also glucose-related protein 78 localization in the aorta. Conclusions This indicates that DADS inhibits diet-induced hypercholesterolemia, at least in parts by regulating ER stress markers. DADS may be a good candidate for treating individuals with diet-induced hypercholesterolemia.

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Section: Discussionsupporting

confidence: 93%

Diallyl disulfide alleviates hypercholesterolemia induced by a western diet by suppressing endoplasmic reticulum stress in apolipoprotein E-deficient mice

Kim¹

2023

BMC Complement Med Ther

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“…The present work clarified that Piroxicam administration induces small apoptotic hepatocytes with condensed pyknotic nuclei. Such finding is similar to widespread apoptosis in the mice liver following administration of Indomethacin, and can be attenuated by L-cystein [24], Furthermore, apoptosis might switch to focal areas of coagulative necrosis when large numbers of hepatocytes are undergoing apoptotic changes [25]. Inflammatory cells infiltration around the blood vessels is a noticeable response to any detrimental impacts.…”

Section: Discussionmentioning

confidence: 75%

Histological changes induced by Piroxicam on the hepatic and renal tissues of mice with and without administration of Peppermint oil

Al-Hamdany

Al-Tai

Ismail

2022

Current Issues in Pharmacy and Medical Sciences

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Piroxicam is a popular anti-inflammatory drug that displays palliative and antipyretic activity. Peppermint oil is a common flavoring used in foods and drinks. To investigate the defensive action of Peppermint oil against the hepatic and renal histological damage induced by Piroxicam in mice. Forty healthy adult Swiss albino mice of both sexes were categorized into 4 groups (10 mice in each group): Control group (I); Treatment group (II) – injected with Piroxicam 0.3 mg/kg/rat/day via intraperitoneal route for 28 days; Treatment group (III) – oral Peppermint oil 0.2 ml/kg/day by oral gavage 24 hours preceding each injection of Piroxicam; Treatment group (IV) oral Peppermint oil alone. Blood samples were withdrawn to estimate the hepatic and renal functions. Immediately after death, specimens of liver and kidney from the four groups were isolated and put in 10% concentration buffered formalin for 24 hours then prepared for light microscopic examination. There was a highly significant rise in the serum level of hepatic enzymes (alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase and total serum bilirubin) in the group treated with Piroxicam, as compared to the control group. These returned to near normal level in the group treated with Piroxicam and Peppermint oil. Liver samples of the treated mice showed ballooning degeneration of hepatocytes, small apoptotic hepatocytes and inflammatory cellular infiltration, whereas kidney sections revealed cystic dilatation of Bowman’s space, shrinkage of glomerular tuft and apoptosis of epithelial cells lining the tubules. In contrast, the addition of peppermint oil efficiently ameliorated the hepatic and renal tissue changes. Piroxicam induces hepatorenal toxicity as exhibited by histological, histochemical and biochemical findings. Peppermint oil shows ameliorative properties against the hepatorenal toxic effects induced by Piroxicam.

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Manganese abated indomethacin-induced gastrohepatorenal toxicities in Rats via suppression of oxidative stress, polyamine catabolism, inflammation and activation of Caspase-3

Tijani

Olori

Farombi³

2023

Advances in Redox Research

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S‐allyl‐L‐cysteine protects hepatocytes from indomethacin‐induced apoptosis by attenuating endoplasmic reticulum stress

Cited by 8 publications

References 51 publications

Diallyl disulfide alleviates hypercholesterolemia induced by a western diet by suppressing endoplasmic reticulum stress in apolipoprotein E-deficient mice

Diallyl disulfide alleviates hypercholesterolemia induced by a western diet by suppressing endoplasmic reticulum stress in apolipoprotein E-deficient mice

Histological changes induced by Piroxicam on the hepatic and renal tissues of mice with and without administration of Peppermint oil

Manganese abated indomethacin-induced gastrohepatorenal toxicities in Rats via suppression of oxidative stress, polyamine catabolism, inflammation and activation of Caspase-3

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