S-Adenosylmethionine Metabolism and Aging

Loenen, W. A. M.

doi:10.1016/b978-0-12-811060-7.00003-6

Cited by 9 publications

(4 citation statements)

References 428 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Other proteins involved in the availability of substrates for epigenetic modifications have also been implicated in aging. For example, s-Adenosylmethionine (SAM), the universal methyl donor important for histone and DNA methylation, is altered throughout the body of mouse species with atypical lifespans [ 197 , 198 , 213 ]. Although SAM has not been explicitly implicated in age-related memory impairment, it is also altered in other neurodegenerative and neurodevelopmental diseases [ 213 ].…”

Section: Manipulating Histone Ptms To Treat Age-related Memory Impmentioning

confidence: 99%

“…For example, s-Adenosylmethionine (SAM), the universal methyl donor important for histone and DNA methylation, is altered throughout the body of mouse species with atypical lifespans [ 197 , 198 , 213 ]. Although SAM has not been explicitly implicated in age-related memory impairment, it is also altered in other neurodegenerative and neurodevelopmental diseases [ 213 ]. These data are particularly notable because it suggests that metabolic shifts which affect availability of epigenetic pre-cursors could underlie age-related changes in PTMs and DNA methylation.…”

Section: Manipulating Histone Ptms To Treat Age-related Memory Impmentioning

confidence: 99%

See 1 more Smart Citation

Epigenetic Mechanisms of Learning and Memory: Implications for Aging

Creighton

Stefanelli

Reda

et al. 2020

IJMS

View full text Add to dashboard Cite

The neuronal epigenome is highly sensitive to external events and its function is vital for producing stable behavioral outcomes, such as the formation of long-lasting memories. The importance of epigenetic regulation in memory is now well established and growing evidence points to altered epigenome function in the aging brain as a contributing factor to age-related memory decline. In this review, we first summarize the typical role of epigenetic factors in memory processing in a healthy young brain, then discuss the aspects of this system that are altered with aging. There is general agreement that many epigenetic marks are modified with aging, but there are still substantial inconsistencies in the precise nature of these changes and their link with memory decline. Here, we discuss the potential source of age-related changes in the epigenome and their implications for therapeutic intervention in age-related cognitive decline.

show abstract

Section: Manipulating Histone Ptms To Treat Age-related Memory Impmentioning

confidence: 99%

Section: Manipulating Histone Ptms To Treat Age-related Memory Impmentioning

confidence: 99%

Epigenetic Mechanisms of Learning and Memory: Implications for Aging

Creighton

Stefanelli

Reda

et al. 2020

IJMS

View full text Add to dashboard Cite

show abstract

“…Since histone methyltransferases rely on the availability of the universal methyl donor SAM, it would be interesting to study the regulation of this metabolite in old flies and their hearts. Evidence currently suggests that SAM is important for heart function and healthy aging [219], possibly in part by regulating the levels of histone methylation. In fact, the Radical S-Adenosyl methionine Domain containing 1 (RSAD1) enzyme has been linked to heart development, and mutations lead to congenital heart disease [220].…”

Section: Crosstalk Between Epigenetics and Metabolism With Agementioning

confidence: 99%

As time flies by: Investigating cardiac aging in the short-lived Drosophila model

Blice-Baum

Guida

Hartley

et al. 2019

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

View full text Add to dashboard Cite

“…Apart from the RNA methyltransferases, SAM is also the native methyl-group donor for DNA methyltransferases 17,18 and protein methyltransferases 19,20 . SAM-dependent methylation is also involved in many other important biological processes, including the generation of a wide range of secondary metabolites such as flavonoids, neurotransmitters or antibiotics 21 .…”

Section: Introductionmentioning

confidence: 99%

Novel RNA m⁶A methyltransferase METTL16 inhibitors

Selberg

Ivanova

Kotli

et al. 2023

Preprint

View full text Add to dashboard Cite

The overexpression of RNA 6-N-methyladenosine (m6A) methyltransferase METTL16 has oncogenic role in the case of several cancer types, including leukemia, but efficient small-molecule inhibitors are not available. Initially identified by high-throughput virtual screening of the ZINC15 database in vivo subset, but then confirmed by measuring catalytic activity, two nanomolar-active METTL16 inhibitors, compounds 1 (IC50 = 25.82 ± 17.19 nM) and 2 (IC50 = 60.91 ± 2.75 nM) were found. The inhibitory activity of the compounds was measured using the m6A antibody-based ELISA assay. We also present the results on the effect of these inhibitors on the viability of promyeloblast HL-60 and lymphoblast CCRF-CEM leukemia cell lines. In unstressed growth conditions, both identified METTL16 inhibitors reduced the viability of HL-60 cells by up to 40%. The effect on the viability of CCRF-CEM cells was smaller with no dose dependency observed. In parallel, the level of the m6A as compared to unmodified adenosine in the HL-60 cell mRNAs was significantly reduced by the inhibitor 1. Collectively, we herein demonstrate novel METTL16 inhibitors that exert tumor cell-lineage-selective antiproliferative effects.

show abstract

S-Adenosylmethionine Metabolism and Aging

Cited by 9 publications

References 428 publications

Epigenetic Mechanisms of Learning and Memory: Implications for Aging

Epigenetic Mechanisms of Learning and Memory: Implications for Aging

As time flies by: Investigating cardiac aging in the short-lived Drosophila model

Novel RNA m⁶A methyltransferase METTL16 inhibitors

Contact Info

Product

Resources

About

S-Adenosylmethionine Metabolism and Aging

Cited by 9 publications

References 428 publications

Epigenetic Mechanisms of Learning and Memory: Implications for Aging

Epigenetic Mechanisms of Learning and Memory: Implications for Aging

As time flies by: Investigating cardiac aging in the short-lived Drosophila model

Novel RNA m6A methyltransferase METTL16 inhibitors

Contact Info

Product

Resources

About

Novel RNA m⁶A methyltransferase METTL16 inhibitors