S-Adenosylmethionine Attenuates Oxidative Stress and Neuroinflammation Induced by Amyloid-β Through Modulation of Glutathione Metabolism

Li, Qian; Cui, Jing; Chen, Fang; Liu, Min; Min, Guowen; Liang, Li

doi:10.3233/jad-170177

Cited by 43 publications

(26 citation statements)

References 43 publications

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“…This could be an adaptive process used by the delayed birds to attenuate their stress response as this is reported for the domesticated birds compared to their wild counterparts [43]. Furthermore, the contribution of 3 metabolites known for their antioxidant effects [44, 45], i.e. citrulline (LC, − 1.40), taurine (LC, − 0.76), and adenosylmethionine (LC, − 0.12) was higher in the delayed groups, also suggesting an adaptive response of the D chickens to negative postnatal events.…”

Section: Discussionmentioning

confidence: 99%

A multiplatform metabolomic approach to characterize fecal signatures of negative postnatal events in chicks: a pilot study

Beauclercq

Lefèvre

Montigny

et al. 2019

J Animal Sci Biotechnol

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Background Negative experiences in early life can induce long-lasting effects on the welfare, health, and performance of farm animals. A delayed placement of chicks in rearing houses has negative effects on their performance, and results in fecal-specific odors detectable by rats. Based on this observation, the volatile organic compounds (VOCs) and metabolites from the feces of 12-day-old chickens were screened for early markers of response to negative events using gas-chromatography and liquid-chromatography coupled with mass spectrometry (GC-MS, LC-HRMS). Results The low reproducibility of solid-phase micro-extraction of the VOCs followed by GC-MS was not suitable for marker discovery, in contrast to liquid extraction of metabolites from freeze-dried feces followed by GC-MS or LC-HRMS analysis. Therefore, the fecal metabolome from 12-day-old chicks having experienced a normal or delayed placement were recorded by GC-MS and LC-HRMS in two genotypes from two experiments. From both experiments, 25 and 35 metabolites, respectively explaining 81% and 45% of the difference between delayed and control chickens, were identified by orthogonal partial least-squares discriminant analysis from LC-HRMS and GC-MS profiling. Conclusion The sets of molecules identified will be useful to better understand the chicks’ response to negative events over time and will contribute to define stress or welfare biomarkers. Electronic supplementary material The online version of this article (10.1186/s40104-019-0335-8) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

A multiplatform metabolomic approach to characterize fecal signatures of negative postnatal events in chicks: a pilot study

Beauclercq

Lefèvre

Montigny

et al. 2019

J Animal Sci Biotechnol

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“…In addition, it was shown that in valproic acid (VPA)-exposed dams, treatment with high doses of folic acid, vitamin E and the methyl donor methionine could ameliorate or prevent most of the VPA-induced damage [100,101]. S-adenosylmethionine (SAM) is known to reduce oxidative stress in several organs [102][103][104]. In the brain, this molecule inhibited lipid peroxidation and supported the glutathione system [102].…”

Section: Targeting Ros To Treat Asdmentioning

confidence: 99%

Oxidative Stress and Immune System Dysfunction in Autism Spectrum Disorders

Pangrazzi

Balasco

Bozzi

2020

IJMS

152

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Autism Spectrum Disorders (ASDs) represent a group of neurodevelopmental disorders associated with social and behavioral impairments. Although dysfunctions in several signaling pathways have been associated with ASDs, very few molecules have been identified as potentially effective drug targets in the clinic. Classically, research in the ASD field has focused on the characterization of pathways involved in neural development and synaptic plasticity, which support the pathogenesis of this group of diseases. More recently, immune system dysfunctions have been observed in ASD. In addition, high levels of reactive oxygen species (ROS), which cause oxidative stress, are present in ASD patients. In this review, we will describe the major alterations in the expression of genes coding for enzymes involved in the ROS scavenging system, in both ASD patients and ASD mouse models. In addition, we will discuss, in the context of the most recent literature, the possibility that oxidative stress, inflammation and immune system dysfunction may be connected to, and altogether support, the pathogenesis and/or severity of ASD. Finally, we will discuss the possibility of novel treatments aimed at counteracting the interplay between ROS and inflammation in people with ASD.

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“…Many studies show that SAM administration alleviates oxidant stress and restores the tissues. For example, Li et al [ 23 ] found that SAM administration protects cells and inhibits oxidative stress induced by amyloid- β , and it activates endogenous antioxidant system by restoring the normal GSH/GSSG ratio and increasing the activities of glutathione peroxidase (GSH-Px), glutathione-S-transferase (GST), and superoxide dismutase (SOD).…”

Section: Methioninementioning

confidence: 99%

Oxidation Resistance of the Sulfur Amino Acids: Methionine and Cysteine

Peng

Huang

Zhou

2017

BioMed Research International

174

135

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Sulfur amino acids are a kind of amino acids which contain sulfhydryl, and they play a crucial role in protein structure, metabolism, immunity, and oxidation. Our review demonstrates the oxidation resistance effect of methionine and cysteine, two of the most representative sulfur amino acids, and their metabolites. Methionine and cysteine are extremely sensitive to almost all forms of reactive oxygen species, which makes them antioxidative. Moreover, methionine and cysteine are precursors of S-adenosylmethionine, hydrogen sulfide, taurine, and glutathione. These products are reported to alleviate oxidant stress induced by various oxidants and protect the tissue from the damage. However, the deficiency and excess of methionine and cysteine in diet affect the normal growth of animals; thereby a new study about defining adequate levels of methionine and cysteine intake is important.

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S-Adenosylmethionine Attenuates Oxidative Stress and Neuroinflammation Induced by Amyloid-β Through Modulation of Glutathione Metabolism

Cited by 43 publications

References 43 publications

A multiplatform metabolomic approach to characterize fecal signatures of negative postnatal events in chicks: a pilot study

A multiplatform metabolomic approach to characterize fecal signatures of negative postnatal events in chicks: a pilot study

Oxidative Stress and Immune System Dysfunction in Autism Spectrum Disorders

Oxidation Resistance of the Sulfur Amino Acids: Methionine and Cysteine

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