1991
DOI: 10.1159/000138792
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S-Adenosylhomocysteine Levels Are Not Involved in the Spasmolytic Activity of 3-Deazaadenosine in Guinea-Pig Lung Parenchyma

Abstract: The effects of two S-adenosylhomocysteine (SAH) hydrolase inhibitors, MDL 28,842 and 3-deazaadenosine (3-DAA), on the tissue levels of SAH, cAMP and cGMP and on the contractile responses to leukotriene D4 and histamine were compared in guinea-pig lung parenchyma. MDL 28,842 and 3-DAA (both in the presence of L-homocysteine) increased tissue levels of SAH to the same degree, indicating that both compounds had inhibited SAH hydrolase. However, only 3-DAA inhibited the contractile response of the lung … Show more

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Cited by 3 publications
(1 citation statement)
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“…Addition of Hcy favours formation of c~AdoHcy [12,13,50,61]. A role for c3AdoHcy in inhibition of the contractile response in guinea-pig lung parenchyma has been shown previously by Gieske et al [21]. A role for c3AdoHcy in inhibition of the contractile response in guinea-pig lung parenchyma has been shown previously by Gieske et al [21].…”
Section: Discussionmentioning
confidence: 86%
“…Addition of Hcy favours formation of c~AdoHcy [12,13,50,61]. A role for c3AdoHcy in inhibition of the contractile response in guinea-pig lung parenchyma has been shown previously by Gieske et al [21]. A role for c3AdoHcy in inhibition of the contractile response in guinea-pig lung parenchyma has been shown previously by Gieske et al [21].…”
Section: Discussionmentioning
confidence: 86%