RYIRFamide: a turbellarian FMRFamide-related peptide (FaRP)

Maule, Aaron G.; Shaw, Christopher; Halton, D W; Curry, W.J.; Thim, Lars

doi:10.1016/0167-0115(94)90189-9

Cited by 56 publications

(18 citation statements)

References 13 publications

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“…In total, we characterized 142 peptides biochemically, corresponding to ∼45% of the distinct peptides predicted from our collection of 51 prohormone genes (Table S5). This analysis identified genes encoding relatives of all previously characterized flatworm neuropeptides (YIRFamide [53], spp-11 ; FRFamide [54], npp-4 ; and neuropeptide Y-like [55], npy-1 to npy-11 ) and provided biochemical validation for 10 prohormones previously predicted from the S. mediterranea genome [39].…”

Section: Resultsmentioning

confidence: 88%

Genome-Wide Analyses Reveal a Role for Peptide Hormones in Planarian Germline Development

et al. 2010

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Section: Resultsmentioning

confidence: 88%

Genome-Wide Analyses Reveal a Role for Peptide Hormones in Planarian Germline Development

et al. 2010

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“…Physiology studies demonstrate that neuropeptides have contractile and regulatory effects on flatworm muscle and other tissues (Day et al, 1994; Marks et al, 1997; Hrckova et al, 2004; Humphries et al, 2004; Kreshchenko et al, 2008). The breadth of these insights is remarkable given the paucity of structural data on endogenous flatworm neuropeptides – only eight native sequences have been described, defining two structural families: four FMRFamide-like peptides (FLPs; short bioactive peptides with C-terminal -RF.NH 2 motifs) and four neuropeptide Fs (NPFs; 36–39 amino acid peptides with conserved C-terminal Y (−17) Y (−10) GRPRF.NH 2 motif) (Curry et al, 1992; Maule et al, 1992, 1993, 1994; Johnston et al, 1995, 1996). FLPs and NPFs are functionally different, reflecting their distinct structures.…”

Section: Introductionmentioning

confidence: 99%

Discovery of multiple neuropeptide families in the phylum Platyhelminthes

McVeigh

Mair

Atkinson³

et al. 2009

International Journal for Parasitology

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Available evidence shows that short amidated neuropeptides are widespread and have important functions within the nervous systems of all flatworms (phylum Platyhelminthes) examined, and could therefore represent a starting point for new lead drug compounds with which to combat parasitic helminth infections. However, only a handful of these peptides have been characterised, the rigorous exploration of the flatworm peptide signalling repertoire having been hindered by the dearth of flatworm genomic data. Through searches of both expressed sequence tags and genomic resources using the basic local alignment search tool (BLAST), we describe 96 neuropeptides on 60 precursors from 10 flatworm species. Most of these (51 predicted peptides on 14 precursors) are novel and are apparently restricted to flatworms; the remainder comprise nine recognised peptide families including FMRFamide-like (FLPs), neuropeptide F (NPF)-like, myomodulin-like, buccalin-like and neuropeptide FF (NPFF)-like peptides; notably, the latter have only previously been reported in vertebrates. Selected peptides were localised immunocytochemically to the Schistosoma mansoni nervous system. We also describe several novel flatworm NPFs with structural features characteristic of the vertebrate neuropeptide Y (NPY) superfamily, previously unreported characteristics which support the common ancestry of flatworm NPFs with the NPY-superfamily. Our dataset provides a springboard for investigation of the functional biology and therapeutic potential of neuropeptides in flatworms, simultaneously launching flatworm neurobiology into the post-genomic era.

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“…Several families of neuropeptides have been either identified by structure (Maule et al 1991(Maule et al , 1993(Maule et al , 1994Fig. 1.…”

Section: Discussionmentioning

confidence: 99%

Gonadotropin‐releasing hormone‐like immunoreactivity in the planarian Bdelloura candida (Platyhelminthes, Tricladida)

Anctil

Tekaya

2005

Invertebrate Biology

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Abstract. Although peptides similar to gonadotropin‐releasing hormone (GnRH) peptides have been reported in various taxa of invertebrates, no such evidence has yet been identified for platyhelminths. Antibodies raised against mammalian GnRH were used to investigate the distribution of GnRH immunoreactivity in specimens of the triclad turbellarian Bdelloura candida (Maricola, Bdellouridae). While no GnRH immunoreactivity was detected in the brain and nerve cords, both the putative subepidermal and submuscular nerve plexuses appeared to be immunoreactive. GnRH immunoreactivity was also present in epidermal mucous cells, in parenchymal cells, including cells surrounding the branches of the intestine, in putative neuroendocrine cells associated with the testes, and in the vitellogenic gland cells associated with the oviduct. These observations suggest that the GnRH‐like material found in specimens of B. candida may be involved in a variety of functions, including a possible pheromone‐like role for mucous cells and the control of specific reproductive activities.

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RYIRFamide: a turbellarian FMRFamide-related peptide (FaRP)

Cited by 56 publications

References 13 publications

Genome-Wide Analyses Reveal a Role for Peptide Hormones in Planarian Germline Development

Genome-Wide Analyses Reveal a Role for Peptide Hormones in Planarian Germline Development

Discovery of multiple neuropeptide families in the phylum Platyhelminthes

Gonadotropin‐releasing hormone‐like immunoreactivity in the planarian Bdelloura candida (Platyhelminthes, Tricladida)

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