RYGB Produces more Sustained Body Weight Loss and Improvement of Glycemic Control Compared with VSG in the Diet-Induced Obese Mouse Model

Zheng, Hao; Townsend, R. Leigh; Mumphrey, Michael B.; Morrison, Christopher D.; Münzberg, Heike; Berthoud, Hans‐Rudolf

doi:10.1007/s11695-017-2660-3

Cited by 44 publications

(41 citation statements)

References 41 publications

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“…Similar to other reports [12,19,20], body weight and food intake were both declined within first 2 weeks in Sham group, then turned to increasing thereafter, indicating the impact of surgical stress lasted for 2 weeks in this study. Mice in RYGB group, however, continue to loss weight until 5 weeks after surgery.…”

Section: Discussionsupporting

confidence: 91%

“…Unlike the mice in Sham group regained all the lost weight and became 16±2% heavier at 12 weeks after surgery, body weight of the mice in RYGB group were kept at its lowest level in the whole postoperative period despite the food intake increased to be the same as Sham group. These findings demonstrated that RYGB is effective on long-term body weight loss which is consistent with clinical studies [12,19,20].…”

Section: Discussionsupporting

confidence: 89%

“…The feces collected at 11 weeks after surgery was weighted and measured for its energy level, which showed that there was significantly higher level of energy in the feces from RYGB group than Sham group (Fig.2 d), indicating energy from food were lost remarkably through feces in the long-term after RYGB (12 weeks in mouse lifespan equal 7 years in human lifespan [12]).…”

Section: Modified Technique Improved Surgical Outcome After Rygbmentioning

confidence: 99%

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Increased Energy Expenditure and Energy Loss through Feces Contribute to the Long-term Outcome of Roux-en-Y Gastric Bypass on Diet Induced Obese Mouse Model

Chen¹,

Xiao²,

Zhou³

et al. 2020

Preprint

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Background Roux-en-Y gastric bypass (RYGB) has been proved to be more effective than other bariatric procedures in long-term on body weight loss and remission of diabetes. However, the mechanism remains poorly understood. Long-term change of energy metabolism after RYGB has rarely been reported. Objectives To investigate the long-term outcome of RYGB on mouse model and its mechanism from the perspective of energy metabolism. Methods High-fat diet induced obesity (DIO) mice were assigned to two groups receiving RYGB(n=8) and sham operation(n=7), followed by high-fat diet feeding until 12 weeks after surgery. Body weight and food intake were recorded weekly, measurement of body composition and energy metabolism by metabolic chamber were conducted on week 4, 8 and 12 after surgery. Fecal energy measurement, Intraperitoneal Glucose Tolerance Test (IPGTT) and Insulin Tolerance Test (ITT) were conducted on week 12 after surgery.Results Food intake was reduced in RYGB group within the first 3 weeks after surgery and increased to be the same withSham group from postoperative week 4. At 12 weeks after surgery, body weight reduced by 36±3.2% in RYGB group comparing to 16±2% body weight gain in Sham group, while fat mass was significantly reduced in RYGB group than in Sham group (9.2±1.5% versus 30.1±0.7%). Energy expenditure was significantly higher on postoperative week 8 in RYGB group than in Sham group. In comparison with Sham group, respiratory exchange ratio (RER) was unchanged, decreased and increased in RYGB group at postoperative week 4, 8 and 12, respectively. Fecal energy measurementshowed that feces from mice in RYGB group contained higher energy level than Sham group. Glucose metabolism was significantly improved in RYGB group in contrast to Sham group, demonstrated by the result of Intraperitoneal Glucose Tolerance Test (IPGTT) (AUC: 1502± 104 versus 2277±198, respectively) and the Insulin Tolerance Test (ITT) (AUC: 524 ±50 versus 838±63, respectively). Conclusions Increased energy expenditure and energy loss through feces contribute to the long-term body weight control after RYGB. Enhanced glucose utilization might play a role in the long-term improvement of glucose metabolism.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 89%

Section: Modified Technique Improved Surgical Outcome After Rygbmentioning

confidence: 99%

See 1 more Smart Citation

Increased Energy Expenditure and Energy Loss through Feces Contribute to the Long-term Outcome of Roux-en-Y Gastric Bypass on Diet Induced Obese Mouse Model

Chen¹,

Xiao²,

Zhou³

et al. 2020

Preprint

View full text Add to dashboard Cite

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“…Weight regain and type-2 diabetes relapse has been reported in a significant proportion of VSG both in patients and in mice ( Felsenreich et al, 2016 ). Further, VSG is less effective to lastingly suppress body weight and improve glycemic control compared with RYGB in mice ( Hao et al, 2017 ). Together with our observation that EDGB provides a metabolic benefit identical to RYGB, these findings suggest that EDGB may be a better approach for weight reduction and glycemic control relative to VSG, although the long-term effects remain to be investigated.…”

Section: Discussionmentioning

confidence: 99%

“…VSG is rapidly gaining popularity with a trend to replace RYGB surgery because of its less damage and fewer complications. However, studies in mice have found that VSG is less effective for lasting reduction in body weight and improvement on glycemic control relative to RYGB, the gold standard surgery, in mice ( Hao et al, 2017 ). Further, removal of majority of the stomach renders it impossible to reverse the procedure in case complications such as anemia and severe bone loss occur ( Angrisani et al, 2015 , Buchwald et al, 2004 ).…”

Section: Introductionmentioning

confidence: 99%

Esophagus-duodenum Gastric Bypass Surgery Improves Glucose and Lipid Metabolism in Mice

Yin

et al. 2018

EBioMedicine

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BackgroundDespite of its significant therapeutic effects on obesity and metabolic diseases, Roux-en-Y gastric bypass (RYGB) has limited clinical application because of considerable impacts on the gastrointestinal structure and postoperative complications. This study aims to develop a simplified surgical approach with less damage and complication but efficient metabolic benefit.MethodsThe effects of Esophagus-Duodenum gastric bypass (EDGB) on body weight, food intake, glucose and lipid metabolism were compared to RYGB in mice.FindingsEDGB is simple, has higher survival rate and less complication. Relative to RYGB, EDGB demonstrated modest body weight control, identical improvement of glucose and lipid metabolism in obese mice. Blood glucose increased significantly 15 and 30 min after oral glucose administration, then markedly decreased in both EDGB and RYGB groups relative to the sham surgery, indicating a quicker absorption of oral glucose and improvement in glucose uptake by insulin targeted tissues. Insulin sensitivity was identically improved. EDGB significantly decreased plasma and hepatic triglyceride levels, while increased browning in visceral and subcutaneous white adipose tissue to the extent identical to RYGB. Levels of ghrelin and nesfatin-1 increased significantly after EDGB and RYGB.InterpretationEDGB is a valuable model to study the metabolic benefit of bariatric surgery in mice.

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Effects of bariatric surgery on functional connectivity of the reward and default mode network: A pre‐registered analysis

Heinrichs

Beyer

Medawar

et al. 2021

Human Brain Mapping

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Obesity imposes serious health risks and involves alterations in resting‐state functional connectivity of brain networks involved in eating behavior. Bariatric surgery is an effective treatment, but its effects on functional connectivity are still under debate. In this pre‐registered study, we aimed to determine the effects of bariatric surgery on major resting‐state brain networks (reward and default mode network) in a longitudinal controlled design. Thirty‐three bariatric surgery patients and 15 obese waiting‐list control patients underwent magnetic resonance imaging at baseline, after 6 and 12 months. We conducted a pre‐registered whole‐brain time‐by‐group interaction analysis, and a time‐by‐group interaction analysis on within‐network connectivity. In exploratory analyses, we investigated the effects of weight loss and head motion. Bariatric surgery compared to waiting did not significantly affect functional connectivity of the reward network and the default mode network (FWE‐corrected p > .05), neither whole‐brain nor within‐network. In exploratory analyses, surgery‐related BMI decrease (FWE‐corrected p = .041) and higher average head motion (FWE‐corrected p = .021) resulted in significantly stronger connectivity of the reward network with medial posterior frontal regions. This pre‐registered well‐controlled study did not support a strong effect of bariatric surgery, compared to waiting, on major resting‐state brain networks after 6 months. Exploratory analyses indicated that head motion might have confounded the effects. Data pooling and more rigorous control of within‐scanner head motion during data acquisition are needed to substantiate effects of bariatric surgery on brain organization.

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RYGB Produces more Sustained Body Weight Loss and Improvement of Glycemic Control Compared with VSG in the Diet-Induced Obese Mouse Model

Cited by 44 publications

References 41 publications

Increased Energy Expenditure and Energy Loss through Feces Contribute to the Long-term Outcome of Roux-en-Y Gastric Bypass on Diet Induced Obese Mouse Model

Increased Energy Expenditure and Energy Loss through Feces Contribute to the Long-term Outcome of Roux-en-Y Gastric Bypass on Diet Induced Obese Mouse Model

Esophagus-duodenum Gastric Bypass Surgery Improves Glucose and Lipid Metabolism in Mice

Effects of bariatric surgery on functional connectivity of the reward and default mode network: A pre‐registered analysis

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