Ryanodine Receptor Type III (Ry3R) Identification In Mouse Parotid Acini

DiJulio, Dennis H.; Watson, Eileen L.; Pessah, Isaac N.; Jacobson, Kerry L.; Ott, Sabrina M.; Buck, Edmond D.; Singh, J.

doi:10.1074/jbc.272.25.15687

Cited by 47 publications

(33 citation statements)

References 66 publications

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“…Alternatively, the presence of such a ryanodine-sensitive cAMP-dependent Ca 2ϩ release pathway, not observed in this study, may simply be the result of species differences. As stated previously, mouse parotid acinar cells express predominantly RyR 3 (62), whereas rat parotid acinar cells (revealed by reverse transcription-PCR) express predominantly RyR 1 (21). Because RyR 1 exhibit a lower threshold for activation by Ca 2ϩ (63), any potentiation of Ca 2ϩ release by cAMP would be amplified under conditions of elevated resting [Ca 2ϩ ] i (18,21,22).…”

Section: Discussionmentioning

confidence: 75%

Phosphorylation of Inositol 1,4,5-Trisphosphate Receptors in Parotid Acinar Cells

Bruce

Shuttleworth

Giovannucci

et al. 2002

Journal of Biological Chemistry

139

142

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Section: Discussionmentioning

confidence: 75%

Phosphorylation of Inositol 1,4,5-Trisphosphate Receptors in Parotid Acinar Cells

Bruce

Shuttleworth

Giovannucci

et al. 2002

Journal of Biological Chemistry

139

142

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“…In the absence of calyculin A, PKI (14)(15)(16)(17)(18)(19)(20)(21)(22) had no effect on either AA-induced Ca 2ϩ release or Ca 2ϩ entry ( Enhancement of AA-induced-Ca 2ϩ release is dependent on ryanodine-sensitive stores. Previous studies from our laboratory demonstrated that RyRs are present in mouse parotid acini (9) and that AA induces release of Ca 2ϩ from ryanodinesensitive stores (46). Thus we determined whether AA-induced augmentation of Ca 2ϩ entry by calyculin A was dependent on the release of Ca 2ϩ from ryanodine-sensitive stores.…”

Section: Methodsmentioning

confidence: 94%

“…Forskolin alone, however, had no effect on resting [Ca 2ϩ ]. In the second experiment, we determined whether forskolin also potentiates the effects of AA (45 M) on Ca 2ϩ release, because this compound was reported to enhance the binding of [ 3 H]ryanodine to mouse parotid microsomal membranes (9) and to activate RyRs in isolated parotid acini (46). As shown in Fig.…”

Section: Methodsmentioning

confidence: 99%

Inhibition of serine/threonine phosphatase enhances arachidonic acid-induced [Ca²⁺]_i via protein kinase A

Saino

Watson²

2009

American Journal of Physiology-Cell Physiology

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“…IP 3 then induces an increase in [Ca 2ϩ ] i , whereas DAG activates protein kinase C (PKC) (Putney, 1986;Baum, 1993). The ryanodine receptor type III has also been identified in microsomal membranes of mouse parotid acini and has an important role in Ca 2ϩ homeostasis (Dijulio et al, 1997). In Ca 2ϩ -mediated intracellular signal transduction mechanisms, an increase in [Ca 2ϩ ] i has an important role in the activation of Ca 2ϩ /calmodulin (CaM)-dependent proteins, such as CaM kinases, myosin light chain kinase (MLCK), and nitric-oxide synthase (NOS).…”

mentioning

confidence: 99%

The Muscarinic Acetylcholine Receptor-Stimulated Increase in Aquaporin-5 Levels in the Apical Plasma Membrane in Rat Parotid Acinar Cells Is Coupled with Activation of Nitric Oxide/cGMP Signal Transduction

2002

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The present study investigated the role of nitric oxide (NO)/cGMP signal transduction in the M 3 muscarinic acetylcholine receptor (mAChR)-stimulated increase in aquaporin-5 (AQP5) levels in the apical plasma membrane (APM) of rat parotid glands. Pretreatment of rat parotid tissue with the NO scavenger 2-(4carboxyphe-nyl)-4,4,5,5-tetramethyl-imidazoline-1-oxyl-3-oxide potassium inhibited both acetylcholine (ACh)-and pilocarpine-induced increases in AQP5 in the APM. NO donors [3-morpholinosydnonimine (SIN-1) and (S)-nitroso-N-acetylpenicillamine (SNAP)] mimicked the effects of mAChR agonists. A selective protein kinase G inhibitor [(9S,10R,12R)-2,3,9,10,11,12-hexahydro-10-methoxy-2,9-dimethyl-1-oxo-9,12-epoxy-1H-diindolo-[1,2,3-fg-3Ј,2Ј,1Ј-kl]pyrrolo [3,4-i] . These results suggest that NO/cGMP signal transduction has a crucial role in Ca 2ϩ homeostasis in the mAChR-stimulated increase in AQP5 levels in the APM of rat parotid glands.Several aquaporins (AQPs), which form water channels that selectively transport water across the plasma membrane, have been cloned from a variety of mammalian tissues (King and Agre, 1996). In the gastrointestinal tract, more than seven AQPs are known to be expressed: AQP1 in intrahepatic cholangiocytes; AQP4 in gastric parietal cells; AQP3 and AQP4 in colonic surface epithelium; AQP5 in salivary glands; AQP7 in small intestine; AQP8 in liver, pancreas, colon, and salivary glands; and AQP9 in liver (Ma and Verkman, 1999). AQP5 was cloned from the rat submandibular gland (Raina et al., 1995). The nucleotide sequence of AQP5 reveals 45 and 63% homology with AQP1 and AQP2, respectively (Raina et al., 1995). Salivary fluid secretion is defective in transgenic mice lacking AQP5, indicating that AQP5 is important in salivary gland function Krane et al., 2001). The sympathetic and parasympathetic nerves in rat parotid glands regulate the role of AQP5. Acetylcholine (ACh) and epinephrine acting at M 3 muscarinic acetylcholine receptors (mAChR) and ␣ 1 -adrenoceptors, respectively, inThis work was supported in part by a grant-in-aid for scientific research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan.ABBREVIATIONS: AQP, aquaporin; ACh, acetylcholine; mAChR, muscarinic acetylcholine receptor; APM, apical plasma membrane; SNI-2011, cevimeline hydrochloride; PLC, phospholipase C; IP 3, inositol 1,4,5-trisphosphate; DAG, 1,2-diacylglycerol; PKC, protein kinase C; CaM, calmodulin; MLCK, myosin light chain kinase; NOS, nitric-oxide synthase; GC, guanylate cyclase; NO, nitric oxide; PKG, protein kinase G; BAPTA-AM, 1,2-bis(2-aminophenoxy)ethane-N,N,NЈ,NЈ-tetraacetic acid-acetoxymethyl ester; Carboxy-PTIO, 2-(4carboxyphenyl)-4,4,5,5-tetramethyl-imidazoline-1-oxyl-3-oxide potassium; IBMX, 3-isobutyl-1-methylxanthine; SIN-1, 3-morpholinosydnonimine; SNAP, (S)-nitroso-N-acetylpenicillamine; KN-62; (8)-5-isoquinolinesulfonic acid, 4-[2-(5-isoquinolinyl-sulfonyl)methylamino]-3-oxo-(4-phenyl-1-piperazinyl)-propyl]phenyl ester; ML9, (5-chloronaphthalene-1-sulfonyl...

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Ryanodine Receptor Type III (Ry3R) Identification In Mouse Parotid Acini

Cited by 47 publications

References 66 publications

Phosphorylation of Inositol 1,4,5-Trisphosphate Receptors in Parotid Acinar Cells

Phosphorylation of Inositol 1,4,5-Trisphosphate Receptors in Parotid Acinar Cells

Inhibition of serine/threonine phosphatase enhances arachidonic acid-induced [Ca²⁺]_i via protein kinase A

The Muscarinic Acetylcholine Receptor-Stimulated Increase in Aquaporin-5 Levels in the Apical Plasma Membrane in Rat Parotid Acinar Cells Is Coupled with Activation of Nitric Oxide/cGMP Signal Transduction

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Ryanodine Receptor Type III (Ry3R) Identification In Mouse Parotid Acini

Cited by 47 publications

References 66 publications

Phosphorylation of Inositol 1,4,5-Trisphosphate Receptors in Parotid Acinar Cells

Phosphorylation of Inositol 1,4,5-Trisphosphate Receptors in Parotid Acinar Cells

Inhibition of serine/threonine phosphatase enhances arachidonic acid-induced [Ca2+]i via protein kinase A

The Muscarinic Acetylcholine Receptor-Stimulated Increase in Aquaporin-5 Levels in the Apical Plasma Membrane in Rat Parotid Acinar Cells Is Coupled with Activation of Nitric Oxide/cGMP Signal Transduction

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Inhibition of serine/threonine phosphatase enhances arachidonic acid-induced [Ca²⁺]_i via protein kinase A