RXR, un cofacteur essentiel à la transformation dans les leucémies aiguës promyélocytaires

Halftermeyer, Juliane; Bras, Morgane Le

doi:10.1051/medsci/20112711013

Cited by 4 publications

(2 citation statements)

References 31 publications

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“…The present study, analyzing 452 pregnancies from 2000 to 2009, found an HIV MTCT rate of 3.74%, which was above the expected for a reference maternity, in which nationally [23] and internationally accepted standard prophylactic measures are routinely employed in the care of HIV infected pregnant women. However, further studying of the 15 cases of transmission of HIV has shown particular results that explain such numbers.…”

Section: Discussionmentioning

confidence: 48%

Mother-to-child transmission of human immunodeficiency virus in aten years period

et al. 2011

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Objectivesto evaluate mother-to-child transmission (MTCT) rates and related factors in HIV-infected pregnant women from a tertiary hospital between 2000 and 2009.Subjects and methodcohort of 452 HIV-infected pregnant women and their newborns. Data was collected from recorded files and undiagnosed children were enrolled for investigation. Statistical analysis: qui-square test, Fisher exact test, Student t test, Mann-Whitney test, ANOVA, risk ratio and confidence intervals.ResultsMTCT occurred in 3.74%. The study population displayed a mean age of 27 years; 86.5% were found to have acquired HIV through sexual contact; 55% were aware of the diagnosis prior to the pregnancy; 62% were not using HAART. Mean CD4 cell-count was 474 cells/ml and 70.3% had undetectable viral loads in the third trimester. HAART included nevirapine in 35% of cases and protease inhibitors in 55%; Zidovudine monotherapy was used in 7.3%. Mean gestational age at delivery was 37.2 weeks and in 92% by caesarian section; 97.2% received intravenous zidovudine. Use of AZT to newborn occurred in 100% of them. Factors identified as associated to MTCT were: low CD4 cell counts, elevated viral loads, maternal AIDS, shorter periods receiving HAART, other conditions (anemia, IUGR (intra uterine growth restriction), oligohydramnium), coinfecctions (CMV and toxoplasmosis) and the occurrence of labor. Use of HAART for longer periods, caesarian and oral zidovudine for the newborns were associated with a decreased risk. Poor adhesion to treatment was present in 13 of the 15 cases of transmission; in 7, coinfecctions were diagnosed (CMV and toxoplasmosis).ConclusionUse of HAART and caesarian delivery are protective factors for mother-to-child transmission of HIV. Maternal coinfecctions and other conditions were risk factors for MTCT.

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Section: Discussionmentioning

confidence: 48%

Mother-to-child transmission of human immunodeficiency virus in aten years period

et al. 2011

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“…Traditional treatment is focused on chemotherapy. In recent years, tretinoin and AS 2 O 3 , through the effect on the PML/RARα fusion gene, have induced differentiation and apoptosis of tumor cells and thus greatly improved the long-term survival rate of patients with APL [9]. However, with the expansion of clinical application to cases, we gradually discovered that both tretinoin and AS 2 O 3 have distinct individual differences on curative effect, drug resistance, recurrence rate and other side effects to varying degrees [10,11].…”

Section: Discussionmentioning

confidence: 99%

The impact of Tegillarca granosa extract haishengsu on HL-60 cell

et al. 2015

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Haishengsu (Hss) is a purified protein from Tegillarca granosa that has been used as a traditional Chinese medicine to treat cancer for more than a century. In this study, we observed the impact of Haishengsu (Hss) on the proliferation and differentiation of HL-60 cells in the leukemic cell line by taking tretinoin and AS2O3 as a positive control and making a comparative analysis between the effect of Hss and tretinoin and AS2O3. We found that Hss could significantly inhibit the proliferation of HL-60 cells and caused most of the cells to stay in the G0/G1 phase. Its effect was much stronger than that of tretinoin and AS2O3, and the ability of Hss to induce differentiation was close to tretinoin. Hss functions probably by inhibiting the expression of the Bcl-2 and MPO genes and further promoting the expression of the Bax gene. Hss has a significant effect on both inhibiting the proliferation and inducing the differentiation of HL-60 cells. It is possible that Hss may be a new kind of clinical differentiation inducer.

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Identification of Anticancer Drug Candidate Targeting Nuclear Receptor Retinoid X receptor‐α from Natural Products using Receptor‐Ligand Recognition

et al. 2016

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Natural products (NP), especially medicinal plants, have been used worldwide to treat numerous diseases for thousands of years. However, drug discovery focus has been moving away from identifying lead compounds from complex mixtures of crude NP because this approach is technically difficult and inefficient. We here present a quick, accurate and practical method for screening leads targeting a nuclear receptor from NP mixtures. Using themethod, we rapidly identified erythrotriol as a new lead compoundfrom medicinal plant Hibiscus syriacus L.targeting RXRα for treating cancer with less side effects. This method can efficiently and profitably screen lead compounds targeting nuclear receptors and may reinvigorate interest in NP as sources of pharmaceutical agents.

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RXR, un cofacteur essentiel à la transformation dans les leucémies aiguës promyélocytaires

Cited by 4 publications

References 31 publications

Mother-to-child transmission of human immunodeficiency virus in aten years period

Mother-to-child transmission of human immunodeficiency virus in aten years period

The impact of Tegillarca granosa extract haishengsu on HL-60 cell

Identification of Anticancer Drug Candidate Targeting Nuclear Receptor Retinoid X receptor‐α from Natural Products using Receptor‐Ligand Recognition

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