Rv0100: An essential acyl carrier protein from M. tuberculosis important in dormancy
Hiten J. Gutka,
Jasper Marc G. Bondoc,
Ryan Patwell
et al.
Abstract:We have identified an acyl-carrier protein, Rv0100, that is up-regulated in a dormancy model. This protein plays a critical role in the fatty acid biosynthesis pathway, which is important for energy storage and cell wall synthesis in Mycobacterium tuberculosis (MTB). Knocking out the Rv0100 gene resulted in a significant reduction of growth compared to wild-type MTB in the Wayne model of non-replicating persistence. We have also shown that Rv0100 is essential for the growth and survival of this pathogen during… Show more
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