Ruxolitinib in patients with polycythemia vera resistant and/or intolerant to hydroxyurea: European observational study
Alexandre Theocharides,
Heinz Gisslinger,
Valerio De Stefano
et al.
Abstract:BackgroundHydroxyurea (HU) is a commonly used first‐line treatment in patients with polycythemia vera (PV). However, approximately 15%–24% of PV patients report intolerance and resistance to HU.MethodsThis phase IV, European, real‐world, observational study assessed the efficacy and safety of ruxolitinib in PV patients who were resistant and/or intolerant to HU, with a 24‐month follow‐up. The primary objective was to describe the profile and disease burden of PV patients.ResultsIn the 350 enrolled patients, 70… Show more
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