Rutin: therapeutic potential and recent advances in drug delivery

Sharma, Shrestha; Ali, Asgar; Ali, Javed; Sahni, Jasjeet Kaur; Baboota, Sanjula

doi:10.1517/13543784.2013.805744

Cited by 309 publications

(174 citation statements)

References 78 publications

Supporting

Mentioning

168

Contrasting

Unclassified

Order By: Relevance

“…Rutin is the glycosidic form of quercetin. The pharmacological effect of rutin is well documented for antidiabetic conditions (Middha et al 2013;Sharma et al 2013). The presence of rutin in the bamboo extract can induce the b cells to produce insulin and/or protect the b cells from deterioration and, thus, help in reducing diabetes.…”

Section: Hplc Analysis Of Baqe Leaf Extractmentioning

confidence: 99%

Analysis of toxic, antidiabetic and antioxidant potential of Bambusa balcooa Roxb. leaf extracts in alloxan-induced diabetic rats

Goyal

Middha²,

Usha³

et al. 2017

3 Biotech

View full text Add to dashboard Cite

Bambusa balcooa (Poaceae) is native to India and has been used traditionally by the tribes of Northeast India to treat diabetes. The present investigation was aimed to evaluate the toxicity, anti-diabetic activity along with in vitro antioxidant activity of the leaf of B. balcooa in alloxan-induced diabetic rats and also identify active compounds by using HPLC. The acute toxicity test of aqueous extract of B. balcooa leaf revealed that the median lethal dose (LD 50 ) of B. balcooa aqueous extract (BAQE) was 5.18 g/kg body weight in mice. Administration of BAQE at 100 and 200 mg/kg in alloxan-induced diabetic rats showed significant reduction in fasting blood glucose and glycated hemoglobin while plasma insulin level was elevated compared to diabetic control. Both the doses were effective when compared to diabetic glibenclamide rats. The BAQE treated diabetic rats showed significant increase in the endogenous antioxidant enzymes superoxide dismutase, glutathione peroxidase and decrease in malondialdehyde levels. HPLC analysis of BAQE showed the presence of rutin, gallic acid and b sitosterol. Thus, it can be inferred from this study that BAQE possess antidiabetic and in vivo antioxidant activity. The overall activity might be possibly due to the presence of potential antioxidants.

show abstract

Section: Hplc Analysis Of Baqe Leaf Extractmentioning

confidence: 99%

Analysis of toxic, antidiabetic and antioxidant potential of Bambusa balcooa Roxb. leaf extracts in alloxan-induced diabetic rats

Goyal

Middha²,

Usha³

et al. 2017

3 Biotech

View full text Add to dashboard Cite

show abstract

“…This fact as well as its poor aqueous solubility, contribute to its low bioavailability (Sharma et al, 2013) and therefore to a limited pharmacological activity. Considering rutin as one of the secondary metabolites responsible for the hypoglycemic effect presented by BFPP, polymer hypromellose phthalate (HPMCP) was chosen for microparticles development.…”

Section: Microencapsulation Of Bfpp In Hpmcpmentioning

confidence: 99%

Development and optimization of microparticles containing a hypoglycemic fraction of calyces from Physalis peruviana

2018

J App Pharm Sci

View full text Add to dashboard Cite

Physalis peruviana L. (Cape gooseberry) is a plant widely cultivated in the Andean mountain in South America and its calyces are the main by-product of the harvest and commercialization of the fruits. Hypoglycemic activity was evaluated to the hydroethanolic extract and its fractions by glucose tolerance test. Since butanolic fraction exhibited hypoglycemic activity as well as the hydroethanolic extract, this fraction was microencapsulated in hypromellose phthalate (HPMCP) by the emulsification-evaporation method. Rutin was the major flavonoid in the whole extract and butanolic fraction. By using Plackett-Burman and Box-Behnken statistical experimental designs, were developed and optimized HPMCP-microparticles loaded with butanolic fraction. Optimized microparticles have an entrapment efficiency of 71% and yield of 64%, only 8% of release at acidic pH and significant hypoglycemic activity. Development and optimization of microencapsulated butanolic fraction of calyces from P. peruviana is an important contribution to improve its hypoglycemic activity as a promising therapeutic strategy.

show abstract

“…It was used not only as antimicrobial, antifungal, and antiallergic agent; but also for the treatment of various chronic diseases such as cancer, diabetes, hypertension and hypercholesterolemia. Compared to other flavonoids, rutin is considered as a nontoxic and nonoxidizable molecule [38]. Both naringin and naringenin are strong antioxidants [39,40].…”

Section: Quantification and Biological Importancementioning

confidence: 99%

LC-MS Analysis of Phenolic Acids, Flavonoids and Betanin from Spineless <i>Opuntia ficus-indica</i> Fruits

Slimen¹,

Mabrouk²,

Chaâbane³

et al. 2017

View full text Add to dashboard Cite

Abstract:Opuntia ficus-indica belongs to the Cactaceae family and is widespread in semi-arid and arid regions. Cactus pears are known for their health promoting properties which are due to a variety of bioactive molecules. This study aims to identify and quantify phenolic acids, flavonoids and betanin from spineless Opuntia ficus-indica fruits. Fresh mature samples were crushed, and extracted with 50% aqueous ethanol. The identification process was carried out using a Shimadzu high performance liquid chromagraph equipped with a quadrupole mass spectrum. Quantification was made using calibration curves of analytical standards. 9 phenolic acids, 1 flavan-3-ol, 2 flavanones, 3 flavonols, 6 flavones and 2 betacyanins were identified. Important levels of betanin, quinic acid, cirsiliol, acacetin, transcinnamic acid, rutin and naringin were calculated. Our results indicated that Opuntia ficus-indica fruits are an important dietary source of phenolic compounds and betalains with high antioxidant capacity.

show abstract

Rutin: therapeutic potential and recent advances in drug delivery

Cited by 309 publications

References 78 publications

Analysis of toxic, antidiabetic and antioxidant potential of Bambusa balcooa Roxb. leaf extracts in alloxan-induced diabetic rats

Analysis of toxic, antidiabetic and antioxidant potential of Bambusa balcooa Roxb. leaf extracts in alloxan-induced diabetic rats

Development and optimization of microparticles containing a hypoglycemic fraction of calyces from Physalis peruviana

LC-MS Analysis of Phenolic Acids, Flavonoids and Betanin from Spineless <i>Opuntia ficus-indica</i> Fruits

Contact Info

Product

Resources

About

Rutin: therapeutic potential and recent advances in drug delivery

Cited by 309 publications

References 78 publications

Analysis of toxic, antidiabetic and antioxidant potential of Bambusa balcooa Roxb. leaf extracts in alloxan-induced diabetic rats

Analysis of toxic, antidiabetic and antioxidant potential of Bambusa balcooa Roxb. leaf extracts in alloxan-induced diabetic rats

Development and optimization of microparticles containing a hypoglycemic fraction of calyces from Physalis peruviana

LC-MS Analysis of Phenolic Acids, Flavonoids and Betanin from Spineless &lt;i&gt;Opuntia ficus-indica&lt;/i&gt; Fruits

Contact Info

Product

Resources

About

LC-MS Analysis of Phenolic Acids, Flavonoids and Betanin from Spineless <i>Opuntia ficus-indica</i> Fruits