Rutin targets AKT to inhibit ferroptosis in ventilator‐induced lung injury
Shengsong Chen,
Zhonghao Li,
Yuhong Xiao
et al.
Abstract:Our previous research confirmed that rutin reduced ventilator‐induced lung injury (VILI) in mice. Ferroptosis has been reported to participate in the pathogenic process of VILI. We will explore whether rutin inhibits ferroptosis to alleviate VILI. A mouse model of VILI was constructed with or without rutin pretreatment to perform a multiomics analysis. Hematoxylin–eosin (HE) staining and transmission electron microscopy were used to evaluate lung injury in VILI mice. Dihydroethidium (DHE) staining and the malo… Show more
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