Rutin restrains the growth and metastasis of mouse breast cancer cells by regulating the microRNA‐129‐1‐3p‐mediated calcium signaling pathway

Li, Qi; Xu, Dongsheng; Gu, Zhengtao; Li, Tengteng; Huang, Peng; Ren, Liqun

doi:10.1002/jbt.22794

Cited by 21 publications

(16 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 50 Study in breast cancer indicated that rutin restrained the growth and metastasis of mouse breast cancer cells by regulating the miRNA-129-1-3p-mediated calcium signaling pathway. 51 Among these three reports about miR-20b-5p, the last two were consistent with the current result, that is, rutin plays an anti-cancer role by regulating miRNA. However, none of the above studies emphasized the function of rutin on regulating miRNA in glioma.…”

Section: Discussionsupporting

confidence: 90%

Purple sweet potato delphinidin-3-rutin represses glioma proliferation by inducing miR-20b-5p/Atg7-dependent cytostatic autophagy

Wang

Liu

et al. 2022

Molecular Therapy - Oncolytics

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 90%

Purple sweet potato delphinidin-3-rutin represses glioma proliferation by inducing miR-20b-5p/Atg7-dependent cytostatic autophagy

Wang

Liu

et al. 2022

Molecular Therapy - Oncolytics

View full text Add to dashboard Cite

“…Therefore, it can be inferred that breast cancer cells need more cytoplasmic Ca 2+ for survival, and sevoflurane may increase breast cancer cells survival via modulating intracellular Ca 2+ homeostasis. Indeed, in a mouse model of breast cancer ( 72 ), regulation of the microRNA-129-1-3p-mediated calcium signaling pathway has been shown to restrain the growth of breast cancer cells. MicroRNAs are noncoding RNA molecules which participate in post-transcriptional gene regulation.…”

Section: Effects Of Sevoflurane and Propofol On Microenvironments Of Breast Cancer Cellsmentioning

confidence: 99%

Effects of Propofol Versus Sevoflurane on Postoperative Breast Cancer Prognosis: A Narrative Review

et al. 2022

View full text Add to dashboard Cite

Perioperative interventions produce substantial biologic perturbations which are associated with the risk of recurrence after cancer surgery. The changes of tumor microenvironment caused by anesthetic drugs received increasing attention. Till now, it’s still unclear whether or not anesthetic drugs may exert positive or negative impact on cancer outcomes after surgery. Breast cancer is the most common tumor and the leading cause of cancer deaths in women. Propofol and sevoflurane are respectively the most commonly used intravenous and inhaled anesthetics. Debates regarding which of the two most commonly used anesthetics may relatively contribute to the recurrence and metastasis vulnerability of breast cancer postoperatively remain. This review aimed to provide a comprehensive view about the effect of propofol versus sevoflurane on the prognosis of breast cancer obtained from pre-clinical studies and clinical studies. Laboratory and animal studies have demonstrated that sevoflurane may enhance the recurrence and metastasis of breast cancer, while propofol is more likely to reduce the activity of breast cancer cells by attenuating the suppression of the immune system, promoting tumor cells apoptosis, and through other direct anti-tumor effects. However, retrospective clinical studies have shown contradictory results about the effects of propofol and sevoflurane on long-term survival in breast cancer patients. Furthermore, recent prospective studies did not identify significant differences between propofol and sevoflurane in breast cancer metastasis and recurrence. Therefore, more preclinical studies and randomized controlled studies are needed to guide the choice of anesthetics for breast cancer patients.

show abstract

“…Rutin has also been demonstrated to mitigate breast cancer cell growth via regulation of the microRNA-129-1-3p-mediated calcium signaling pathway. Overexpression of microRNA-129-1-3p mediated by rutin suppressed the proliferation, invasion, migration, and calcium overload of mouse breast cancer cells (4T1), thereby enhancing apoptosis in 4T1 cells [95]. Rutin has also been shown to have a protective effect against colorectal cancer.…”

Section: Rutinmentioning

confidence: 99%

“…colon [85], and liver [86,89] cancer, and oral squamous cell carcinoma [87] ↓ PolIII, Brf1, TNFα, iNOS, Cox2, MMP-2, MMP-9, Akt, NFκB, and c-myc Rutin Oranges, wine, and grapes ↑ Caspase-3, Caspase-9, Bax, TNF-α, GSK3-β, and p53 Neuroblastoma [91], cervical [92,94], breast [93], colorectal, lung [95,96], and prostate [97] cancer ↓ Notch-1, Hes-1, Bcl2, HPV-E6, HPV-E7, Cox2, and IL-6…”

mentioning

confidence: 99%

The Anti-Cancer Effects of Red-Pigmented Foods: Biomarker Modulation and Mechanisms Underlying Cancer Progression

2022

View full text Add to dashboard Cite

Cancer is one the most malignant diseases that is a leading cause of death worldwide. Vegetables and fruits contain beneficial nutrients such as vitamins, minerals, folates, dietary fibers, and various natural bioactive compounds. These can prevent the pathological processes of many cancers and reduce cancer related mortality. Specifically, the anti-cancer effect of vegetables and fruits is largely attributable to the natural bioactive compounds present within them. A lot of bioactive compounds have very specific colors with pigments and the action of them in the human body varies by their color. Red-pigmented foods, such as apples, oranges, tomatoes, cherries, grapes, berries, and red wine, have been widely reported to elicit beneficial effects and have been investigated for their anti-tumor, anti-inflammatory, and antioxidative properties, as well as anti-cancer effect. Most of the anti-cancer effects of bioactive compounds in red-pigmented foods arise from the suppression of cancer cell invasion and metastasis, as well as the induction of apoptosis and cell cycle arrest. In this review, we assessed publications from the last 10 years and identified 10 bioactive compounds commonly studied in red-pigmented foods: lycopene, anthocyanin, β-carotene, pectin, betaine, rutin, ursolic acid, kaempferol, quercetin, and myricetin. We focused on the mechanisms and targets underlying the anti-cancer effect of the compounds and provided rationale for further investigation of the compounds to develop more potent anti-cancer treatment methods.

show abstract

Rutin restrains the growth and metastasis of mouse breast cancer cells by regulating the microRNA‐129‐1‐3p‐mediated calcium signaling pathway

Cited by 21 publications

References 24 publications

Purple sweet potato delphinidin-3-rutin represses glioma proliferation by inducing miR-20b-5p/Atg7-dependent cytostatic autophagy

Purple sweet potato delphinidin-3-rutin represses glioma proliferation by inducing miR-20b-5p/Atg7-dependent cytostatic autophagy

Effects of Propofol Versus Sevoflurane on Postoperative Breast Cancer Prognosis: A Narrative Review

The Anti-Cancer Effects of Red-Pigmented Foods: Biomarker Modulation and Mechanisms Underlying Cancer Progression

Contact Info

Product

Resources

About