Rutin protects against H 2 O 2 -triggered impaired relaxation of placental arterioles and induces Nrf2-mediated adaptation in Human Umbilical Vein Endothelial Cells exposed to oxidative stress

Sthijns, Mireille M.J.P.E.; Schiffers, P. M. H.; Janssen, G. M. E.; Lemmens, Kristien J.A.; Ides, Bart; Vangrieken, Philippe; Bouwman, Freek G.; Mariman, E.C.M.; Pader, Irina; Arnér, Elias S.J.; Johansson, Katarina; Bast, Aalt; Haenen, Guido R.M.M.

doi:10.1016/j.bbagen.2017.03.004

Cited by 42 publications

(27 citation statements)

References 102 publications

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“…In addition, earlier studies have shown that the interaction of rutin with ascorbic acid leads to an increase in the reducing properties of ascorbic acid, which is expressed by a decrease in xanthine oxidase activity, responsible for the cytosol production of superoxide anion [74]. In addition, the combined action of rutin and ascorbic acid was more effective than single compound action in the ROS decrease in the animal tissues [77].…”

Section: Intracellular Ros Generationmentioning

confidence: 97%

“…Moreover, UV radiation decreases the thioredoxin reductase activity as well as thioredoxin level, thereby lowering the effectiveness of thioredoxin-dependent antioxidant system, and exposing the thiol groups of the oxidized proteins to less effective reduction. However, exogenous compounds may activate thioredoxin reductase under oxidative conditions [77], and ascorbic acid and rutin restore the thioredoxindependent system, which is especially important in repairing UV-induced protein modifications. On the other hand, the polyphenolic structure of rutin provides the ability to maintain the redox balance in fibroblasts, which has been already described elsewhere [24].…”

Section: Antioxidant Capacitymentioning

confidence: 99%

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Rutin and ascorbic acid cooperation in antioxidant and antiapoptotic effect on human skin keratinocytes and fibroblasts exposed to UVA and UVB radiation

et al. 2019

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The combination of ascorbic acid and rutin is frequently used in oral preparations. However, despite numerous protective effects of each component individually, their combined effect on ultraviolet (UV)-irradiated skin cells has never been evaluated. The aim of this study was to evaluate the combined effect of ascorbic acid and rutin on human keratinocytes and fibroblasts exposed to UVA and UVB radiation. Skin keratinocytes and fibroblasts exposed to UVA and UVB radiation were treated with ascorbic acid or/and rutin. The total antioxidant properties of both components, as well as their effect on cellular pro-and antioxidant status, lipid and protein oxidation, transmembrane transport, and pro-inflammatory and pro/ antiapoptotic protein expression were measured. The combination of ascorbic acid and rutin had higher antioxidant properties compared to the activity of the single compound alone, and showed a stronger effect against UV-induced reactive oxygen species generation. The ascorbic acid and rutin combination also showed increased antioxidant enzyme activity (catalase, superoxide dismutase, thioredoxin reductase), which was impaired following UV irradiation. Moreover, ascorbic acid additional stimulated UV-induced bilitranslocase activity responsible for rutin transport, and therefore favored rutin effect on Nrf2 pathway, simultaneously differentiating the reaction of keratinocytes and fibroblasts. In keratinocytes, Nrf2 is strongly activated, while in fibroblasts decreased Nrf2 activity was observed. Used mixture, also significantly silenced UV-induced expression of pro-inflammatory factor NFκB and pro-apoptotic proteins such as caspases 3, 8, and 9. These results showed that ascorbic acid and rutin are complementary in their antioxidant actions, transport and signaling functions. Their combined antioxidant, antiinflammatory and antiapoptotic actions suggest rutin and ascorbic acid are a potentially cytoprotective team against UV-induced skin damage.

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Section: Intracellular Ros Generationmentioning

confidence: 97%

Section: Antioxidant Capacitymentioning

confidence: 99%

Rutin and ascorbic acid cooperation in antioxidant and antiapoptotic effect on human skin keratinocytes and fibroblasts exposed to UVA and UVB radiation

et al. 2019

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“…(c) The redox balance can be restored by targeting endogenous modulators of the endogenous antioxidant systems. For example, enhancement of the transcription factor Nrf2 increases (basal) levels of endogenous antioxidant systems (Sthijns et al, ), whereas increasing the transcription factor hypoxia inducible factor (HIF) induces anaerobic metabolism, stimulates angiogenesis, and increases glutaminase‐mediated glutathione synthesis, thereby enhancing endogenous antioxidant systems (Stegen, van Gastel, et al, ; Thirlwell, Schulz, Dibra, & Beck, )…”

Section: The Importance Of the Redox Balancementioning

confidence: 99%

“…(b) The molecular targets are the redox sensor transcription factors Nrf2 and hypoxia inducible factor (HIF). By modulating Nrf2, the regulation of endogenous antioxidant systems (Sthijns et al, ) is induced, resulting in restoration of the redox balance. HIF activation increases anaerobic metabolism, stimulates angiogenesis, and increases glutaminase‐mediated glutathione synthesis, thereby enhancing endogenous antioxidant systems to recover the redox balance (Stegen, van Gastel, et al, ; Thirlwell et al, ).…”

Section: Biomaterials Modulating the Endogenous Antioxidant Systemsmentioning

confidence: 99%

Redox regulation in regenerative medicine and tissue engineering: The paradox of oxygen

Sthijns

Blitterswijk

LaPointe

2018

J Tissue Eng Regen Med

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One of the biggest challenges in tissue engineering and regenerative medicine is to incorporate a functioning vasculature to overcome the consequences of a lack of oxygen and nutrients in the tissue construct. Otherwise, decreased oxygen tension leads to incomplete metabolism and the formation of the so‐called reactive oxygen species (ROS). Cells have many endogenous antioxidant systems to ensure a balance between ROS and antioxidants, but if this balance is disrupted by factors such as high levels of ROS due to long‐term hypoxia, there will be tissue damage and dysfunction. Current attempts to solve the oxygen problem in the field rarely take into account the importance of the redox balance and are instead centred on releasing or generating oxygen. The first problem with this approach is that although oxygen is necessary for life, it is paradoxically also a highly toxic molecule. Furthermore, although some oxygen‐generating biomaterials produce oxygen, they also generate hydrogen peroxide, a ROS, as an intermediate product. In this review, we discuss why it would be a superior strategy to supplement oxygen delivery with molecules to safeguard the important redox balance. Redox sensor proteins that can stimulate the anaerobic metabolism, angiogenesis, and enhancement of endogenous antioxidant systems are discussed as promising targets. We propose that redox regulating biomaterials have the potential to tackle some of the challenges related to angiogenesis and that the knowledge in this review will help scientists in tissue engineering and regenerative medicine realize this aim.

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“…It has also been reported to decrease the levels of isoflurane-induced cytosolic calcium and reactive oxygen species [ 121 ]. Likewise, cellular ROS production induced by several oxidative damaging agents was attenuated by pretreatment with chrysin (2) [ 122 ], naringenin (3) [ 123 ], astilbin (4) [ 53 ], icariin (5) [ 124 ], 7,8-dihydroxyflavone (6) [ 125 ], hyperoside (7) [ 126 ], baicalein (8) [ 127 ], rutin (11) [ 128 ], luteolin (12) [ 129 ], fisetin (15) [ 130 ], nobiletin (16) [ 131 ], kaempferitrin (10) [ 132 ], and quercetin (17) [ 133 ].…”

Section: Resultsmentioning

confidence: 99%

Antidepressant Flavonoids and Their Relationship with Oxidative Stress

Hrițcu

Ionita

Postu

et al. 2017

Oxidative Medicine and Cellular Longevity

102

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Depression is a serious disorder that affects hundreds of millions of people around the world and causes poor quality of life, problem behaviors, and limitations in activities of daily living. Therefore, the search for new therapeutic options is of high interest and growth. Research on the relationship between depression and oxidative stress has shown important biochemical aspects in the development of this disease. Flavonoids are a class of natural products that exhibit several pharmacological properties, including antidepressant-like activity, and affects various physiological and biochemical functions in the body. Studies show the clinical potential of antioxidant flavonoids in treating depressive disorders and strongly suggest that these natural products are interesting prototype compounds in the study of new antidepressant drugs. So, this review will summarize the chemical and pharmacological perspectives related to the discovery of flavonoids with antidepressant activity. The mechanisms of action of these compounds are also discussed, including their actions on oxidative stress relating to depression.

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Rutin protects against H 2 O 2 -triggered impaired relaxation of placental arterioles and induces Nrf2-mediated adaptation in Human Umbilical Vein Endothelial Cells exposed to oxidative stress

Cited by 42 publications

References 102 publications

Rutin and ascorbic acid cooperation in antioxidant and antiapoptotic effect on human skin keratinocytes and fibroblasts exposed to UVA and UVB radiation

Rutin and ascorbic acid cooperation in antioxidant and antiapoptotic effect on human skin keratinocytes and fibroblasts exposed to UVA and UVB radiation

Redox regulation in regenerative medicine and tissue engineering: The paradox of oxygen

Antidepressant Flavonoids and Their Relationship with Oxidative Stress

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