Rutin inhibits proliferation, attenuates superoxide production and decreases adhesion and migration of human cancerous cells

Sghaïer, Mohamed Ben; Pagano, Alessandra; Mousslim, Mohamed; Ammari, Youssef; Kovacic, Hervé; Luis, José

doi:10.1016/j.biopha.2016.11.001

Cited by 117 publications

(72 citation statements)

References 73 publications

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“…Thus, the discovery of new and/or more effective and safe therapies becomes essential. In previous studies, rutin has shown biological activity toward different cancer cell lines, indicating that this natural compound could be a promising anticancer agent [8,16,[18][19][20]39]. However, despite its potential anticancer activity, its low solubility represents a challenge and limits the applicability of rutin.…”

Section: Discussionmentioning

confidence: 99%

Anticancer Activity of Rutin and Its Combination with Ionic Liquids on Renal Cells

et al. 2020

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The renal cell carcinoma (RCC) is the most common type of kidney cancer. Identifying novel and more effective therapies, while minimizing toxicity, continues to be fundamental in curtailing RCC. Rutin, a bioflavonoid widely found in nature, has shown promising anticancer properties, but with limited applicability due to its poor water solubility and pharmacokinetics. Thus, the potential anticancer effects of rutin toward a human renal cancer cell line (786-O), while considering its safety in Vero kidney cells, was assessed, as well as the applicability of ionic liquids (ILs) to improve drug delivery. Rutin (up to 50 µM) did not show relevant cytotoxic effects in Vero cells. However, in 786-O cells, a significant decrease in cell viability was already observed at 50 µM. Moreover, exposure to rutin caused a significant increase in the sub-G1 population of 786-O cells, reinforcing the possible anticancer activity of this biomolecule. Two choline-amino acid ILs, at non-toxic concentrations, enhanced rutin’s solubility/loading while allowing the maintenance of rutin’s anticancer effects. Globally, our findings suggest that rutin may have a beneficial impact against RCC and that its combination with ILs ensures that this poorly soluble drug is successfully incorporated into ILs–nanoparticles hybrid systems, allowing controlled drug delivery.

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Section: Discussionmentioning

confidence: 99%

Anticancer Activity of Rutin and Its Combination with Ionic Liquids on Renal Cells

et al. 2020

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“…In order to explore wood fuel use, further research will address burning experiments and sampling in modern traditional ovens used for pine nut exploitation following a similar methodological approach. Although it is no longer common in the site area due to deforestation, P. halepensis occupies more than 56% of the total forested area of Tunisia (around 297.000 ha, Sghaier and Ammari, 2012), mostly in its northwest and central parts. Aleppo pine plays a major ecologic, economic and social role in this country.…”

Section: Discussionmentioning

confidence: 99%

An ethnoarchaeological study of livestock dung fuels from cooking installations in northern Tunisia

Portillo

Belarte

Ramon

et al. 2017

Quaternary International

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Livestock dung is a valuable material in many rural communities worldwide. In our research area, the site of Althiburos and its surroundings, now el Médéïna, in northwestern Tunisia, dung is the main source of fuel for domestic purposes, primarily the processing and cooking of foods. Ovicaprine dung is daily used in traditional mud tannur type ovens, namely tabouna. The archaeological record shows that mud constructed cooking installations were common during the first millennium BC. Previous studies of phytoliths and dung spherulites at Numidian Althiburos suggested the use of vegetal and fecal matter for fuel purposes. We present here the results of the continuation study based on the comparison between archaeological results (a selection of cooking installations, six hearths and two mud ovens) and those obtained from the ethnographic study of dung fuel materials from the site area. The present study builds up on ethnographic observations and informal interviews (dung collection, management, storage, waste disposal and cooking and baking activities), temperature measurements within the burning fuel, as well as modern material sampling (fresh dung, burned pellets, dung ashes and fuel trash paths) which was followed by integrated studies of phytoliths and calcitic microfossil analyses (dung spherulites and wood ash pseudomorphs) for comparative purposes. The results obtained provided direct evidence regarding the type of fuel sources: dung, wood and a mixing of dung and vegetal matter (wood and agricultural by-products). Dung was used as source of fuel material across time (from the Early Numidian occupation phase, 10th-9th century BC, to the last centuries BC) and space (in different excavation areas and type of installations). Such integrated studies demonstrate the value of combining different microarchaeological techniques and the use of ethnoarchaeological material from site areas.

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“…Additionally, rutin exerts cytoprotective effects on cells exposed to different types of radiation by substantially increasing their viability [16]. Literature data show that the range of toxic concentration of rutin depends on the type of cells, and it has been indicated that rutin has a toxic effect in the range of 125-250 µM in the case of cancer cells [24,25] and, with respect to keratinocytes (HaCaT), toxic effects of rutin are achieved at concentrations even above 1 mM [26].…”

Section: Introductionmentioning

confidence: 99%

Cytoprotective Effect of Ascorbic Acid and Rutin against Oxidative Changes in the Proteome of Skin Fibroblasts Cultured in a Three-Dimensional System

Gęgotek

Jarocka-Karpowicz

2020

Nutrients

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The combination of ascorbic acid and rutin, commonly used in oral preparations for their antioxidant and anti-inflammatory properties, can also be used to protect skin cells from the effects of UV radiation in sunlight. Here, we tested the potential protective effect of ascorbic acid and rutin used together in UVB-irradiated human skin fibroblasts, and assessed the proteomic profile of these cells, grown in a three-dimensional (3D) system. Proteomic findings revealed a combined effect of ascorbic acid and rutin in UV-irradiated fibroblasts against overexpression of pro-inflammatory signaling proteins and DNA reorganization/expression. These effects were not observed when cells were treated with either compounds alone. The antioxidant effects of ascorbic acid and rutin also prevented protein modifications by lipid peroxidation products. Further, ascorbic acid stimulated rutin-protein adduct formation, which supports intra/extracellular signaling and the Nrf2/ARE antioxidant pathway, contributing to the protective effects against UV-induced oxidative stress. The combined effect of ascorbic acid and rutin suggests that this combination of compounds is potentially effective against skin damage caused by UV radiation.

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Rutin inhibits proliferation, attenuates superoxide production and decreases adhesion and migration of human cancerous cells

Cited by 117 publications

References 73 publications

Anticancer Activity of Rutin and Its Combination with Ionic Liquids on Renal Cells

Anticancer Activity of Rutin and Its Combination with Ionic Liquids on Renal Cells

An ethnoarchaeological study of livestock dung fuels from cooking installations in northern Tunisia

Cytoprotective Effect of Ascorbic Acid and Rutin against Oxidative Changes in the Proteome of Skin Fibroblasts Cultured in a Three-Dimensional System

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