Rutin Inhibits Cardiac Apoptosis and Prevents Sepsis-Induced Cardiomyopathy

Abstract

Rutin is a flavanol-type polyphenol that consists of flavanol quercetin and the disaccharide rutinose, which has been reported to exert various biological effects such as antioxidant and anti-inflammatory activities. It is not clear whether rutin has a protective effect on sepsis-induced cardiomyopathy (SIC). In this study, we used male C57BL/6 mice and cecal ligation and puncture (CLP) surgery to establish the model of SIC. Rutin was precautionarily treated (50, 100, 200 mg/kg per day, 7 days) before CLP. The results showed that rutin pretreatment (100, 200 mg/kg per day, 7 days) reduced the mortality of murine sepsis. We chose the 100 mg/kg dose for further studies. Mice were pretreatment with rutin (100 mg/kg per day, 7 days) before subjected to CLP, and myocardial tissue and blood samples were collected 24 h after CLP. Serum levels of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and cTNT decreased, while interleukin-10 (IL-10) increased with rutin pretreatment. The cardiomyocytes apoptosis and mitochondrial dysfunction were also alleviated with rutin pretreatment. In conclusion, this study confirmed the efficacy of rutin-enriched diet in the prophylaxis of cardiac apoptosis and cardiac injury induced by CLP in mouse model. It provides a potential new approach on SIC prophylaxis in sepsis.

Protective Effect of Rutin on Triethylene Glycol Dimethacrylate-Induced Toxicity through the Inhibition of Caspase Activation and Reactive Oxygen Species Generation in Macrophages

“…Genotoxicity, which has a damaging effect on DNA integrity, triggers apoptosis in macrophages [ 36 , 37 ]. In addition, TEGDMA induces DNA damage in gingival fibroblasts, lymphocytes, and oral keratinocytes [ 38 , 39 , 40 ].…”

Rutin and Quercetin Counter Doxorubicin-Induced Liver Toxicity in Wistar Rats via Their Modulatory Effects on Inflammation, Oxidative Stress, Apoptosis, and Nrf2

“…In our previous publication, rutin and quercetin, via suppressing oxidative stress and boosting antioxidant defense system, were labeled as chemopreventive agents against nephrocardiotoxicity induced by doxorubicin [8]. Most of other publications investigated the effects of rutin and quercetin on DXRinduced cardiotoxicity [29][30][31][32][33], but rare published studies assessed their effects on DXR-induced hepatotoxicity [34,35]. However, the mechanisms of actions were not entirely delineated by these studies.…”

Golgi protein 73 promotes LPS-induced cardiac dysfunction via mediating myocardial apoptosis and autophagy

“…Sepsis-induced cardiac dysfunction is a common and severe complication of sepsis. 26 It has been studied extensively, but the specific pathogenesis is still not elucidated. In this study, we found that the expression of GP73 was increased in LPS-treated mouse hearts and LPS-cultured NRCMs.…”