Rutin has intestinal antiinflammatory effects in the CD4+ CD62L+ T cell transfer model of colitis

Mascaraque, Cristina; Aranda, Carlos J.; Ocón, Borja; Monte, María J.; Suárez, Marı́a Dolores; Zarzuelo, Antonio; Marin, J. J. G.; Martínez‐Augustin, Olga

doi:10.1016/j.phrs.2014.09.005

Cited by 87 publications

(54 citation statements)

References 40 publications

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“…Other dietary interventions also inhibit T cell transfer colitis. Oral gavage of 57 mg kg –1 d –1 of rutin inhibited CD4 + CD62L + cells transfer colitis, and reduced colonic expression of TNF‐α, IFN‐γ, IL‐6, and IL‐17 . Capsaicin injections inhibited total CD4 + cells in MLN, as well as ex vivo MLN TNF‐α, IL‐17, and IL‐1β .…”

Section: Discussionmentioning

confidence: 97%

Dietary Prevention of Colitis by Aronia Berry is Mediated Through Increased Th17 and Treg

Pei

Martin

Valdez

et al. 2018

Molecular Nutrition Food Res

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Scope Increased fruit consumption is associated with reduced risk of colitis. It has been investigated whether the anti‐colitic effects of the polyphenol‐rich aronia berry (Aronia mitschurinii ‘Viking’) are mediated through Th17 and Treg. Methods and results Colitis is induced in recombinase activating gene‐1 deficient mice injected with syngeneic CD4+CD62L+ naïve T cells. Mice consume either 4.5% w/w aronia‐berry‐supplemented or a control diet concurrent with T cell transfer. The extent of colitis and immunocyte populations are evaluated at weeks 3 to 7 after transfer. Aronia consumption prevents colitic wasting and reduces colon weight/length ratios relative to the control diet at weeks 5 and 7. Compared to the control diet, aronia feeding increases Treg in mesenteric lymph node at all colitis stages. Treg and regulatory Th17 subpopulations (IL‐17A+IL‐10+ and IL‐17A+IL‐22+) are increased in lamina propria and spleen at week 5 in aronia‐fed mice. Aronia feeding also decreases total CD4+ cells but increases colonic Tregs. The ability of aronia to modulate colonic cytokines is associated with functional T cell IL‐10 and increased diversity of microbiota. Conclusions Aronia berry consumption inhibits adoptive transfer colitis by increasing Treg and regulatory Th17 cells. Dietary modulation of T cells is dynamic and precedes colitic wasting.

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Section: Discussionmentioning

confidence: 97%

Dietary Prevention of Colitis by Aronia Berry is Mediated Through Increased Th17 and Treg

Pei

Martin

Valdez

et al. 2018

Molecular Nutrition Food Res

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“…Csf3 and Map2k6 promote inflammation in dermal repair 28 and collagen-induced arthritis 29 , and Il-6 is central for development of keloid disease 30,31 . Mmp1a is upregulated in inflammatory ischemia 32 , Cxcl1 is a central inflammatory mediator in murine colitis 33 , and Ptgs2 is highly expressed in the inflammatory phase of murine experimental OA 34 .…”

Section: Discussionmentioning

confidence: 99%

Deficiency of hyaluronan synthase 1 (Has1) results in chronic joint inflammation and widespread intra-articular fibrosis in a murine model of knee joint cartilage damage

Chan

Xiao

et al. 2015

Osteoarthritis and Cartilage

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Objective Articular cartilage defects commonly result from traumatic injury and predispose to degenerative joint diseases. To test the hypothesis that aberrant healing responses and chronic inflammation lead to osteoarthritis, we examined spatiotemporal changes in joint tissues after cartilage injury in murine knees. Since intra-articular injection of hyaluronan (HA) can attenuate injury-induced osteoarthritis in wild-type (WT) mice, we investigated a role for HA in the response to cartilage injury in mice lacking HA synthase 1 (Has1−/−). Design Femoral groove cartilage of WT and Has1−/− mice was debrided to generate a non-bleeding wound. Macroscopic imaging, histology, and gene expression were used to evaluate naïve, sham-operated, and injured joints. Results Acute responses (1–2 weeks) in injured joints from WT mice included synovial hyperplasia with HA deposition and joint-wide increases in expression of genes associated with inflammation, fibrosis, and extracellular matrix (ECM) production. By 4 weeks, some resurfacing of damaged cartilage occurred, and early cell responses were normalized. Cartilage damage in Has1−/− mice also induced early responses; however, at 4 weeks, inflammation and fibrosis genes remained elevated with widespread cartilage degeneration and fibrotic scarring in the synovium and joint capsule. Conclusions We conclude that the ineffective repair of injured cartilage in Has1−/− joints can be at least partly explained by the markedly enhanced expression of particular genes in pathways linked to ECM turnover, IL-17/IL-6 cytokine signaling, and apoptosis. Notably, Has1 ablation does not alter gross HA content in the ECM, suggesting that HAS1 has a unique function in the metabolism of inflammatory HA matrices.

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“…For instance, the quercetin glycoside rutin is cleaved by gut bacteria to liberate quercetin, which has anti-inflammatory actions 141 . Both quercetin, luteolin and tetramethoxyluteolin are potent inhibitors of MCs 142 .…”

Section: Treatment and Future Directionsmentioning

confidence: 99%

Gut-Microbiota-Brain Axis and Its Effect on Neuropsychiatric Disorders With Suspected Immune Dysregulation

Petra

Panagiotidou

Hatziagelaki

et al. 2015

Clinical Therapeutics

465

300

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Purpose-Gut microbiota regulate intestinal function and health. However, mounting evidence indicates that they can also influence the immune and nervous systems and vice versa. Here we reviewed the bidirectional relationship between the gut microbiota and the brain, termed microbiota-gut-brain (MGB) axis, and we discuss how it contributes to the pathogenesis of certain disorders, that may involve brain inflammation.Methods-Articles were chosen from Medline since 1980 using the key words anxiety, attention-deficit hypersensitivity disorder (ADHD), autism, cytokines, depression, gut, hypothalamic-pituitary-adrenal (HPA) axis, inflammation, immune system, microbiota, nervous system, neurologic, neurotransmitters, neuroimmune conditions, psychiatric, stress.Findings-Various afferent or efferent pathways are involved in the MGB axis. Antibiotics, environmental and infectious agents, intestinal neurotransmitters/neuromodulators, sensory vagal fibers, cytokines, essential metabolites, all convey information about the intestinal state to the CNS. Conversely, the HPA axis, the CNS regulatory areas of satiety and neuropeptides released from sensory nerve fibers affect the gut microbiota composition directly or through nutrient No. 6,624,148; 6,689,748; 6,984,667, and EPO 1365777, which cover methods and compositions of mast cell blockers, including flavonoids, as well as US patents No 7,906,153 and 8,268,365 for treatment of brain inflammation. Conflicts of interestsThe authors declare no conflicts. availability. Such interactions appear to influence the pathogenesis of a number of disorders in which inflammation is implicated such as mood disorder, autism-spectrum disorders (ASDs), attention-deficit hypersensitivity disorder (ADHD), multiple sclerosis (MS) and obesity. HHS Public AccessImplications-Recognition of the relationship between the MGB axis and the neuroimmune systems provides a novel approach for better understanding and management of these disorders. Appropriate preventive measures early in life or corrective measures such as use of psychobiotics, fecal microbiota transplantation and flavonoids are discussed.

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Rutin has intestinal antiinflammatory effects in the CD4+ CD62L+ T cell transfer model of colitis

Cited by 87 publications

References 40 publications

Dietary Prevention of Colitis by Aronia Berry is Mediated Through Increased Th17 and Treg

Dietary Prevention of Colitis by Aronia Berry is Mediated Through Increased Th17 and Treg

Deficiency of hyaluronan synthase 1 (Has1) results in chronic joint inflammation and widespread intra-articular fibrosis in a murine model of knee joint cartilage damage

Gut-Microbiota-Brain Axis and Its Effect on Neuropsychiatric Disorders With Suspected Immune Dysregulation

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