Rutin Exerts Antitumor Effects on Nude Mice Bearing SW480 Tumor

ROS mediated pro-apoptotic effects of i Tinospora cordifolia i on breast cancer cells

“…However, we did not observe any effect of TcCF on cell cycle distribution in breast cancer cells (data not shown) suggesting that other compounds of TcCF might have more influencing effect on breast cancer cells in our case. On a similar note rutin has also been reported to exert anti-tumor effect against many cancer types including breast, colon and hematological cancers (41,42). Therefore, our experimental findings suggested that the anti-cancer effects of TcCF is accredited to the presence of compounds like quercetin and rutin as well as presence of other bioactive ingredients present in TcCF.…”

Cytoprotective Effect of Ascorbic Acid and Rutin against Oxidative Changes in the Proteome of Skin Fibroblasts Cultured in a Three-Dimensional System

“…Additionally, rutin exerts cytoprotective effects on cells exposed to different types of radiation by substantially increasing their viability [16]. Literature data show that the range of toxic concentration of rutin depends on the type of cells, and it has been indicated that rutin has a toxic effect in the range of 125-250 µM in the case of cancer cells [24,25] and, with respect to keratinocytes (HaCaT), toxic effects of rutin are achieved at concentrations even above 1 mM [26].…”

Rutin as A Novel c-Met Inhibitory Lead for The Control of Triple Negative Breast Malignancies

“…The common naturally multifunctional citrus flavonol bioside rutin (rutoside, quercetin-3- O -rutinoside) is ubiquitous in many vegetables and fruits and appreciated for many health benefits. For instance, rutin supplements are touted as a natural remedy to improve vascular disorders (11). Additionally, it showed anti-oxidant, anti-inflammatory, chemopreventive, and anticancer in vitro and in vivo activities (12).…”