Rutin-Chitosan Nanoparticles: Fabrication, Characterization and Application in Dental Disorders

Patil, Ashwini; Jobanputra, Arpana H.

doi:10.1080/03602559.2014.935425

Cited by 39 publications

(25 citation statements)

References 48 publications

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“…Still, the peak of endothermic melting for KAE-LC NPs was not observed due to the shifted peak of KAE ( Figure 5(B)). Also, the peak of the chitosan (Patila and Jobanputraa 2015) shifted from 190 to 150 C and the peak of the KAE diminished. It can be assumed, through the proof of inclusion, that the presence of KAE in the lecithin/chitosan nanoparticles caused the melting point disappear due to its thermal profile.…”

Section: Intermolecular Interactions Between Kae and Kae-lc Npsmentioning

confidence: 94%

Kaempferol loaded lecithin/chitosan nanoparticles: preparation, characterization, and their potential applications as a sustainable antifungal agent

Torun

Saglam

Özgen

2016

Artificial Cells, Nanomedicine, and Biotechnology

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Flavonoid compounds are strong antioxidant and antifungal agents but their applications are limited due to their poor dissolution and bioavailability. The use of nanotechnology in agriculture has received increasing attention, with the development of new formulations containing active compounds. In this study, kaempferol (KAE) was loaded into lecithin/chitosan nanoparticles (LC NPs) to determine antifungal activity compared to pure KAE against the phytopathogenic fungus Fusarium oxysporium to resolve the bioavailability problem. The influence of formulation parameters on the physicochemical properties of KAE loaded lecithin chitosan nanoparticles (KAE-LC NPs) were studied by using the electrostatic self-assembly technique. KAE-LC NPs were characterized in terms of physicochemical properties. KAE has been successfully encapsulated in LC NPs with an efficiency of 93.8 ± 4.28% and KAE-LC NPs showed good physicochemical stability. Moreover, in vitro evaluation of the KAE-LC NP system was made by the release kinetics, antioxidant and antifungal activity in a time-dependent manner against free KAE. Encapsulated KAE exhibited a significantly inhibition efficacy (67%) against Fusarium oxysporium at the end of the 60 day storage period. The results indicated that KAE-LC NP formulation could solve the problems related to the solubility and loss of KAE during use and storage. The new nanoparticle system enables the use of smaller quantities of fungicide and therefore, offers a more environmentally friendly method of controlling fungal pathogens in agriculture.

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Section: Intermolecular Interactions Between Kae and Kae-lc Npsmentioning

confidence: 94%

Kaempferol loaded lecithin/chitosan nanoparticles: preparation, characterization, and their potential applications as a sustainable antifungal agent

Torun

Saglam

Özgen

2016

Artificial Cells, Nanomedicine, and Biotechnology

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“…In the rutin CST TP-loaded FTIR spectrum, the success of rutin encapsulation is indicated by the presence of rutin characteristics in the encapsulation product. The emergence of new absorption bands such as 1604.77 cm -1 , 1458.18 cm -1 shows the aromatic C=C vibration of rutin flavonoids (Natalia dkk., 2017), absorption 1296,16 cm -1 indicates CO from the phenolic group and 1651.07 cm -1 indicate C=O uptake in rutin flavononoid (Patil and Jobanputra, 2015). The presence of absorbent bands in typical aromatic rings and other rutin absorption bands originally absent in the FTIR spectrum of chitosan and CS-TPP matrix indicates the presence of rutin compounds contained in CS-TPP microparticles.…”

Section: Fourier Transform Infrared (Ftir)mentioning

confidence: 99%

“…In this research, Fourier Transform Infrared (FTIR) analyzes of rutin, chitosan, chitosan-TPP, and rutin contained in chitosan-TPP ( Figure 6). In rutin FTIR spectra, the absorption bands at wave numbers 1651.07 cm -1 and 3410.15 cm -1 indicates C=O uptake in rutin flavononoid and vibration of O-H stretching (Patil and Jobanputra, 2015). Vibration C=C which is characterization of aromatic group of flavonoids is shown in absorption bands 1604.77 cm -1 and 1458.18 cm -1 (Natalia et al, 2017).…”

Section: Fourier Transform Infrared (Ftir)mentioning

confidence: 99%

Encapsulation Rutin with Chitosan-NATPP Using Coaservation Method

Cahyono

Suzery

Hadiyanto

et al. 2018

Reaktor

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This study aims to make microparticles of rutin compounds at various concentrations with NaTPP-chitosan as matrix. Encapsulation is done by coaservation method. The success of encapsulation was identified by UV-Vis spectrophotometry, Fourier Transform Infra-Red (FTIR) spectroscopy and Scanning electron microscopy (SEM). Based on UV-Vis spectrophotometry analysis, the efficiency of encapsulation (EE) and loading capacity (LC) was obtained at 62,43-94,36 and 1,73% -32,1%, at rutine concentration 0,625-11,25 mM. The success of rutin encapsulation is demonstrated by the rutin characteristics of the product seen with the presence of peaks of aromatic rings, indicating the presence of rutin compounds contained in the chitosan matrix. SEM analysis shows rough and porous surface morphology in microcapsules. The rutin release profile of the microcapsules is described as two phase processes, burst release at the initial discharge in the first 30 min followed by slow release. At the highest LC (11.25 mM concentration), it provides greater discharge rates for both synthetic fluid simulations 77.53 ± 3.59% and 78.76 ± 4.00% after 3h of discharge. The controlled release data showed high discharge rates at acidic pH than alkaline pH. Keywords: Rutin, encapsulation, citosan, coaservation

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“…33 Moreover, PF-127 has been reported to be the least toxic of commercially available copolymers. 34 Based on the above mentioned facts, and in continuation with our research on nanoparticles in dental disorders, 17 in the proposed study, we aim to investigate the use thermoresponsive triggered in situ gelling system (CGNPs-gel) as a vehicle for delivery of gallic acid in treatment of dental diseases, which may overcome the problems of conventional dosage form, besides providing sustained release by using a combination of pluronic F127 biodegradable polymer. The study also focused on the antimicrobial activity of CGNPs-gel against isolated pathogens, i.e., Bacillus species and Bacillus pumilus and Pseudomonas aeurogenosa, Acinetobacter junii, Enterococcus faecalis from dental caries and abscess respectively.…”

Section: Introductionmentioning

confidence: 98%

“…Literature revealed that drug encapsulated in nanoparticles matrix is more stable in simulated salivary fluid (SSF) than bare drug. 17 Therefore, in the present study, we intend to prepare in situ gel containing gallic acid-loaded chitosan nanoparticles (CGNPs) for the treatment of periodontal disease.…”

Section: Introductionmentioning

confidence: 99%

Formulation, Characterization and Evaluation of a Thermoresponsive <I>In</I> <I>Situ</I> Gel Containing Gallic Acid-Loaded Chitosan Nanoparticles for the Treatment of Periodontal Disease

Patil¹,

Jobanputra²

2015

j bionanosci

Self Cite

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The present work describes the formulation, characterization and preliminary in vitro drug release studies of a thermoresponsive in situ gel containing gallic acid-loaded chitosan nanoparticles (CGNPs). Chitosan nanoparticles were achieved using the ionic gelation method and the in situ gel was prepared via a cold method. Developed CGNPs were characterized for particle size and zeta potential. Pluronic F127 was used as a gelling agent for dental therapy. Formulated in situ gel was evaluated for clarity, pH, gelation temperature, viscosity, spreadability, drug content, texture profile and stability. The antibacterial potential of CGNPs-gel was evaluated against isolated dental pathogens, in vitro. Results revealed that in situ gel exhibited promising antibacterial activity against dental pathogens viz. Acinetobacter junii and Bacillus species. The results of the in vitro release study indicated that in situ gel achieved superior sustained-release of gallic acid (84% up to 6 hours), so that the formulation could significantly increase gallic acid bioavailability in the periodontal cavity.In conclusion, the in situ gel formulation developed in this work has significant potential for dental applications.

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Rutin-Chitosan Nanoparticles: Fabrication, Characterization and Application in Dental Disorders

Cited by 39 publications

References 48 publications

Kaempferol loaded lecithin/chitosan nanoparticles: preparation, characterization, and their potential applications as a sustainable antifungal agent

Kaempferol loaded lecithin/chitosan nanoparticles: preparation, characterization, and their potential applications as a sustainable antifungal agent

Encapsulation Rutin with Chitosan-NATPP Using Coaservation Method

Formulation, Characterization and Evaluation of a Thermoresponsive <I>In</I> <I>Situ</I> Gel Containing Gallic Acid-Loaded Chitosan Nanoparticles for the Treatment of Periodontal Disease

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