Rutin as an Electrochemical Mediator in the Determination of Captopril using a Graphite Paste Electrode

Abstract

A simple, rapid and sensitive cyclic voltammetry method is described for the determination of the antihypertensive drug captopril in aqueous solution using a graphite paste electrode with rutin as mediator. The catalytic role of rutin in the oxidation of captopril was confirmed by the increase observed in anodic peak current at+0.44 V vs. SCE in the presence of the mediator. Anodic peak current varied linearly with the concentration of captopril in the dynamic range 0.2 to 1.0 mmol L−1. The method exhibited a limit of detection of 89.4 μmol L−1 and a reproducibility of 1 %, values that are comparable with those exhibited by other methodologies employing electrodes without any modification. The recovery rate for the determination of captopril in a pharmaceutical sample was good (91.21 %) suggesting that the described analytical technique would be effective in industrial applications whilst offering a number of advantages over published cyclic voltammetric methods.

Electrochemical Sensor for Determination of Various Phenolic Compounds in Wine Samples Using Fe3O4 Nanoparticles Modified Carbon Paste Electrode

“…(7) The electrochemical oxidation process involves the participation of protons; the higher pH values, the easier the electron loss [ 4 , 9 ]. Other researchers have published works on rutin [ 10 , 11 , 12 , 13 , 14 , 15 ], but less or no work is reported on sinapic acid [ 16 ] and syringic acid. These phenolic acids contain oxidizable phenolic substituents on the aromatic ring or reducible olefinic bond, which is why their voltammetric determination [ 16 , 17 ].…”