Rutin ameliorates inflammation and improves metabolic function: A comprehensive analysis of scientific literature

Muvhulawa, Ndivhuwo; Dludla, Phiwayinkosi V.; Ziqubu, Khanyisani; Mthembu, Sinenhlanhla X. H.; Mthiyane, Fikile T.; Nkambule, Bongani B.; Mazibuko-Mbeje, Sithandiwe E.

doi:10.1016/j.phrs.2022.106163

Cited by 60 publications

(31 citation statements)

References 166 publications

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“…It is currently acknowledged that a large population of people depend on medicinal plants to treat different diseases, which mainly due to ancestral knowledge ( Palhares et al, 2015 ; Muvhulawa et al, 2022 ). Thus, the general interest in the use of medicinal plants to cure various disease conditions has grown over the years ( Rakotoarivelo et al, 2015 ; Michel et al, 2020 ).…”

Section: Safety and The Toxicity Profile Of Moringa Oleiferamentioning

confidence: 99%

A Review on the Antidiabetic Properties of Moringa oleifera Extracts: Focusing on Oxidative Stress and Inflammation as Main Therapeutic Targets

et al. 2022

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Moringa oleifera is one of the popular plants that have shown significant health benefits. Certainly, preclinical evidence (predominantly from animal models) summarized in the current review supports the beneficial effects of Moringa oleifera leaf extracts in combating the prominent characteristic features of diabetes mellitus. This includes effective control of blood glucose or insulin levels, enhancement of insulin tissue sensitivity, improvement of blood lipid profiles, and protecting against organ damage under sustained conditions of hyperglycemia. Interestingly, as major complications implicated in the progression of diabetes, including organ damage, Moringa oleifera leaf and seed extracts could efficiently block the detrimental effects of oxidative stress and inflammation in these preclinical models. Notably, these extracts (especially leaf extracts) showed enhanced effects in strengthening intracellular antioxidant defences like catalase, superoxide dismutase, and glutathione to lower lipid peroxidation products and reduce prominent pro-inflammatory markers such as tumor necrosis factor-α, interleukin (1L)-β, IL-6, monocyte chemoattractant protein-1 and nitric oxide synthase. From animal models of diabetes, the common and effective dose of leaf extracts of Moringa oleifera was 100–300 mg/kg, within the treatment duration of 2–8 weeks. Whereas supplementation with approximately 20 g leaf powder of Moringa oleifera for at least 2 weeks could improve postprandial blood glucose in subjects with prediabetes or diabetes. Although limited clinical studies have been conducted on the antidiabetic properties of Moringa oleifera, current findings provide an important platform for future research directed at developing this plant as a functional food to manage diabetic complications.

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Section: Safety and The Toxicity Profile Of Moringa Oleiferamentioning

confidence: 99%

A Review on the Antidiabetic Properties of Moringa oleifera Extracts: Focusing on Oxidative Stress and Inflammation as Main Therapeutic Targets

et al. 2022

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“…Quercetin and hesperidin) [ 48 ]. Rutin exhibits strong antioxidant potential by decreasing the expression of inflammatory cytokines as reported in literature [ 49 ]. In the current study rutin reduced the formation of AGEs due to the downregulation of the expression of RAGE and NF-κB and decreased production of IL-6 and IL-8.…”

Section: Discussionmentioning

confidence: 89%

Modulatory effects of rutin and vitamin A on hyperglycemia induced glycation, oxidative stress and inflammation in high-fat-fructose diet animal model

Iqbal,

Hafeez Kamran,

Siddique

et al. 2024

PLoS ONE

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In the current study we investigated the impact of combination of rutin and vitamin A on glycated products, the glyoxalase system, oxidative markers, and inflammation in animals fed a high-fat high-fructose (HFFD) diet. Thirty rats were randomly divided into six groups (n = 5). The treatments, metformin (120 mg/kg), rutin (100 mg/kg), vitamin A (43 IU/kg), and a combination of rutin (100 mg/kg) and vitamin A (43 IU/kg) were given to relevant groups of rats along with high-fructose high-fat diet for 42 days. HbA1c, D-lactate, Glyoxylase-1, Hexokinase 2, malondialdehyde (MDA), glutathione peroxidase (GPx), catalase (CAT), nuclear transcription factor-B (NF-κB), interleukin-6 (IL-6), interleukin-8 (IL-8) and histological examinations were performed after 42 days. The docking simulations were conducted using Auto Dock package. The combined effects of rutin and vitamin A in treated rats significantly (p < 0.001) reduced HbA1c, hexokinase 2, and D-lactate levels while preventing cellular damage. The combination dramatically (p < 0.001) decreased MDA, CAT, and GPx in treated rats and decreased the expression of inflammatory cytokines such as IL-6 andIL-8, as well as the transcription factor NF-κB. The molecular docking investigations revealed that rutin had a strong affinity for several important biomolecules, including as NF-κB, Catalase, MDA, IL-6, hexokinase 2, and GPx. The results propose beneficial impact of rutin and vitamin A as a convincing treatment strategy to treat AGE-related disorders, such as diabetes, autism, alzheimer’s, atherosclerosis.

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“…Rutin is a quercetin glycoside in several medicinal and eatable plants, which can effectively improve metabolic function due to its effective antioxidation and anti-inflammatory properties [104]. Rutin can reduce TNF-α, IL-6, cyclooxygenase-2, IL-1β, and other proinflammatory markers, block the activation of NF-κB/MAPK pathways, effectively relieve inflammation and improve metabolic function [104]. Suebsaard et al evaluated the immunomodulatory effect of rutin on monocyte-derived macrophages infected with HP-PRRSV [21].…”

Section: Porcine Reproductive and Respiratory Syndrome Virusmentioning

confidence: 99%

Flavonoids as Potential Antiviral Agents for Porcine Viruses

Zhang

Chen

et al. 2022

Pharmaceutics

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Flavonoids are types of natural substances with phenolic structures isolated from a variety of plants. Flavonoids have antioxidant, anti-inflammatory, anticancer, and antiviral activities. Although most of the research or applications of flavonoids are focused on human diseases, flavonoids also show potential applicability against porcine virus infection. This review focuses on the recent progress in antiviral mechanisms of potential flavonoids against the most common porcine viruses. The mechanism discussed in this paper may provide a theoretical basis for drug screening and application of natural flavonoid compounds and flavonoid-containing herbs to control porcine virus infection and guide the research and development of pig feed additives.

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Rutin ameliorates inflammation and improves metabolic function: A comprehensive analysis of scientific literature

Cited by 60 publications

References 166 publications

A Review on the Antidiabetic Properties of Moringa oleifera Extracts: Focusing on Oxidative Stress and Inflammation as Main Therapeutic Targets

A Review on the Antidiabetic Properties of Moringa oleifera Extracts: Focusing on Oxidative Stress and Inflammation as Main Therapeutic Targets

Modulatory effects of rutin and vitamin A on hyperglycemia induced glycation, oxidative stress and inflammation in high-fat-fructose diet animal model

Flavonoids as Potential Antiviral Agents for Porcine Viruses

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