Rutin ameliorates copper sulfate‐induced brain damage via antioxidative and anti‐inflammatory activities in rats

Arowoogun, Jeremiah; Akanni, Olubukola; Adefisan, Adedoyin O; Owumi, Solomon E.; Tijani, Abiola S; Adaramoye, Oluwatosin A.

doi:10.1002/jbt.22623

Cited by 41 publications

(24 citation statements)

References 90 publications

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“…This corroborates with previous reports on the antioxidative and anti‐inflammatory activities of strawberries (Erukainure, Salau, Oyenihi, et al., 2020; Giampieri et al., 2014; Rutledge et al., 2019). These activities can be attributed to the HPLC‐identified phenolics (Table 1) as they have been well documented for their potent antioxidative and anti‐inflammatory activities (Arowoogun et al., 2021; Salau et al., 2021; Salau et al, 2020).…”

Section: Discussionmentioning

confidence: 98%

Strawberry fruit ( Fragaria x ananassa Romina) juice attenuates oxidative imbalance with concomitant modulation of metabolic indices linked to male infertility in testicular oxidative injury

et al. 2021

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This study investigated the protective properties of strawberry fruit on testicular oxidative injury. Oxidative injury was induced in vitro in testicular tissue homogenates by incubation with ferrous sulphate (FeSO4) in the presence and absence of strawberry fruit extract (SFE) for 30 min at 37˚C, with gallic acid serving as the standard antioxidant drug. Induction of oxidative injury significantly reduced glutathione, cholesterol and triglyceride levels; and inhibited SOD, catalase and ENTPDase activities when compared to normal control. It also led to exacerbated nitric oxide, malondialdehyde, LDL‐cholesterol levels, acetylcholinesterase, ATPase and lipase activities. These effects were, however, reversed following treatment with SFE when compared to the untreated control, except for cholesterol and triglyceride levels. Additionally, the induction of the oxidative injury led to alterations in testicular lipid metabolites that were accompanied by the activation of α‐linolenic acid and linoleic acid metabolic pathways. While SFE treatment had no significant impact on the altered metabolites, it repressed pathways for mitochondrial beta‐oxidation of long‐chain saturated fatty acids and plasmalogen synthesis. High‐performance liquid chromatography analysis of SFE revealed the presence of rutin, caffeic acid, p‐coumarin and cinnamic acid. These data imply the protective potentials of strawberry fruits against testicular oxidative injury.

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Section: Discussionmentioning

confidence: 98%

Strawberry fruit ( Fragaria x ananassa Romina) juice attenuates oxidative imbalance with concomitant modulation of metabolic indices linked to male infertility in testicular oxidative injury

et al. 2021

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“…In an earlier study, psoralen isolated from Dystaenia takeshimana was reported to inhibit COX-2/5-LOX in mouse bone marrow-derived mast cells [33]. A few studies suggest that psoralen derivatives [34,35] and rutin [36][37][38] possess COX-2 inhibitory activity. For instance, 5-methoxy-8-(2-hydroxy-3-buthoxy-3-methylbutyloxy)-psoralen from Angelica dahurica was reported to inhibit induction of COX-2 in bone marrow-derived mast cells [34].…”

Section: Discussionmentioning

confidence: 99%

Himalayan Ficus palmata L. Fruit Extract Showed In Vivo Central and Peripheral Analgesic Activity Involving COX-2 and Mu Opioid Receptors

Tewari

Gupta

Bawari

et al. 2021

Plants

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Analgesic drugs like morphine and non-steroidal anti-inflammatory drugs exhibit several harmful effects. Here, we show for the first time the analgesic activity of Ficus palmata L. fruit extract (FPFE) on different analgesic rat models along with the in silico studies of some of the main phytochemicals of this plant. We performed in vivo pain models, along with in silico docking studies against the active site of COX-2 protein and mu-opioid receptors. A significant (p < 0.05) analgesic effect of FPFE was observed, and it was found that rutin has good pose and score as compared to diclofenac and morphinan antagonist (X-ligand), and psoralen has binding affinity almost equal to diclofenac, but a lower binding affinity as compared to rutin. The results proved that F. palmata fruits have the potential to ameliorate painful conditions.

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“…The level of hepatic NO was assessed using Griess reagent, as previously described by Green et al (Arowoogun et al, 2021; Green et al, 1982). Briefly, the reaction mixture containing equal parts of sample and Griess reagent was incubated for 15 min, and the absorbance was taken at 540 nm.…”

Section: Methodsmentioning

confidence: 99%

Combine effect of exposure to petrol, kerosene and diesel fumes: On hepatic oxidative stress and haematological function in rats

et al. 2021

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Petroleum product fumes (PPFs) containing toxic organic components are pervasive in the environment, emanating from anthropogenic activities, including petroleum exploration and utilization by end-user activities from petrol–gasoline stations. Petrol station attendants are exposed to PPF through inhalation and dermal contact with consequent toxicological implications. We investigated the effects of chronic exposure (60 and 90 days) to petrol (P), kerosene (K) and diesel (D) alone and combined exposure to petrol, kerosene and diesel (PKD) fumes on hepatotoxicity, haematological function and oxidative stress in rats. Following sacrifice, we evaluated hepatic damage biomarkers, blood glucose, oxidative stress and haematological function. Chronic exposure to PPF significantly increased organo-somatic indices, blood glucose, biomarkers of hepatic toxicity and oxidative stress in an exposure duration-dependent manner. There was a simultaneous decrease in the protective capacity of antioxidants. Furthermore, exposure to PPF increased pro-inflammatory biomarkers in rats (90 > 60 days). Regardless of exposure duration, plateletcrit, mean platelet volume, platelet distribution width and red cell distribution width in the coefficient of variation increased, whereas red blood cell count, haemoglobin, packed cell volume, mean corpuscular volume, mean corpuscular haemoglobin, mean corpuscular haemoglobin concentration, white blood cell, lymphocyte, monocyte–basophil–eosinophil mixed counts and platelet count decreased after 60 and 90 days exposure. Microscopic examination of the liver demonstrated hepatic pathological changes paralleling the duration of exposure to PKD fumes. However, the injury observed was lesser to that of rats treated with the diethylnitrosamine – positive control. Our results expanded previous findings and further demonstrated the probable adverse effect on populations’ health occasioned by persistent exposure to PPF. Individuals chronically exposed by occupation to PPF may be at greater risk of developing disorders promoted by continuous oxido-inflammatory perturbation and suboptimal haematological–immunologic function – thereby enabling a permissive environment for pathogenesis notwithstanding the limitation of quantifying PPF absolute values in our model system.

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Rutin ameliorates copper sulfate‐induced brain damage via antioxidative and anti‐inflammatory activities in rats

Cited by 41 publications

References 90 publications

Strawberry fruit ( Fragaria x ananassa Romina) juice attenuates oxidative imbalance with concomitant modulation of metabolic indices linked to male infertility in testicular oxidative injury

Strawberry fruit ( Fragaria x ananassa Romina) juice attenuates oxidative imbalance with concomitant modulation of metabolic indices linked to male infertility in testicular oxidative injury

Himalayan Ficus palmata L. Fruit Extract Showed In Vivo Central and Peripheral Analgesic Activity Involving COX-2 and Mu Opioid Receptors

Combine effect of exposure to petrol, kerosene and diesel fumes: On hepatic oxidative stress and haematological function in rats

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