Rutin: A review on extraction, identification and purification methods, biological activities and approaches to enhance its bioavailability

Gullón, Beatriz; Lú-Chau, Thelmo A.; Moreira, Marı́a Teresa; Lema, Juan M.; Eibes, Gemma

doi:10.1016/j.tifs.2017.07.008

Cited by 428 publications

(246 citation statements)

References 161 publications

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“…Rutin was the major compound detected in CsME. Rutin is a flavonol glycoside (3′,4′,5,7‐tetrahydroxy‐flavone‐3‐rutinoside) (Gullón, Lú‐Chau, Moreira, Lema, & Eibes, ), known as Vitamine P or quercetin‐3‐ O ‐rutinoside (Hosseinzadeh & Nassiri‐Asl, ). It is an important dietary constituent of vegetables, fruit, medicinal plants, tea, and coffee (Azevedo et al, ) and usually coexists with quercetin (Lin, He, & Zha, ).…”

Section: Discussionmentioning

confidence: 99%

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Glucose‐mediated protein glycation: Contribution of methanolic extract of Ceratonia siliqua L. in protection and in vitro potential inhibition of acetylcholinesterase

et al. 2019

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Chronic hyperglycemia presents the major etiology of diabetes mellitus and related complications mainly Alzheimer's disease, via the protein glycation and toxic products generated. In the current study, we investigated the eventual protective effect of the methanolic extract of Ceratonia siliqua L. (CsME) against glucose‐mediated glycation in serum bovine albumin. The multi‐stage glycation markers, namely fructosamines and advanced glycation end products (AGEs) levels were monitored along with measurement of thiol groups; moreover, the in vitro acetylcholinesterase (AChE) inhibition potential was carried out. HPLC was also assessed. Rutin was the main phenolic compound found in CsME. CsME showed a good capacity to inhibit AGEs, fructosamines and protected thiol groups against glycation. CsME exhibited a great AChE inhibition activity. In the present study, CsME prevented glucose‐induced protein glycation, it also exhibited a good inhibition of AChE, suggesting its DM complications such as memory troubles related to AD. Practical applications Neurodegenerative disorders ranging from memory troubles to Alzheimer's disease present the most diabetes mellitus complications and mainly attributed to protein glycation process. Currently, there is a strong trend to search for efficient natural sources of glycation and acetylcholinesterase inhibitors to replace the synthetic ones, whose secondary effects were shown. The present article tries to justify scientifically the wide use of Ceratonia siliqua L. in Moroccan folk medicine, demonstrating that the methanolic extract of leaves from this species presents a promising source of new natural compounds inhibiting acetylcholinesterase and acting in vitro against glycation generated compounds. Furthermore, for the first time, Rutin was the main phenolic compound found in this extract, these encouraging results should be coupled with further studies to integrate it in pharmaceutical formulations. As such, this paper should be of interest to a broad readership, including those interested in Biochemistry, Phytochemistry, pharmacology, and neurosciences.

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Section: Discussionmentioning

confidence: 99%

“…Rutin was the major compound detected in CsME. Rutin is a flavonol glycoside (3′,4′,5,7-tetrahydroxy-flavone-3-rutinoside) (Gullón, Lú-Chau, Moreira, Lema, & Eibes, 2017), known as Vitamine P or quercetin-3-O-rutinoside (Hosseinzadeh & Nassiri-Asl, 2014).…”

Section: Glycation Reaction Induces Modifications Of Protein Second-mentioning

confidence: 99%

Glucose‐mediated protein glycation: Contribution of methanolic extract of Ceratonia siliqua L. in protection and in vitro potential inhibition of acetylcholinesterase

et al. 2019

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“…Flavonoids are common markers in botanical drugs or plant extracts that exhibit biological activity in multiple systems, but present poor bioavailability . This is the case of quercetin‐3‐ O ‐rutinoside (rutin), a glycosylated flavonoid with broad therapeutic interest due to its antidiabetic effect, among other demonstrated pharmacological activity . Its low bioavailability is a result of its low aqueous solubility and intestinal metabolism, when rutin turns into quercetin (its aglycone) and other by‐products …”

Section: Introductionmentioning

confidence: 99%

Matrix effects of the hydroethanolic extract and the butanol fraction of calyces from Physalis peruviana L. on the biopharmaceutics classification of rutin

Moré

Feltrin

Brambila

et al. 2020

Journal of Pharmacy and Pharmacology

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Objectives The Biopharmaceutics Classification System (BCS) categorizes active pharmaceutical ingredients according to their solubility and permeability properties, which are susceptible to matrix or formulation effects. The aim of this research was to evaluate the matrix effects of a hydroethanolic extract of calyces from Physalis peruviana L. (HEE) and its butanol fraction (BF), on the biopharmaceutics classification of their major compound, quercetin‐3‐O‐rutinoside (rutin, RU). Methods Rutin was quantified by HPLC‐UV, and Caco‐2 cell monolayer transport studies were performed to obtain the apparent permeability values (Papp). Aqueous solubility was determined at pH 6.8 and 7.4. Key findings The Papp values followed this order: BF > HEE > RU (1.77 ± 0.02 > 1.53 ± 0.07 > 0.90 ± 0.03 × 10−5 cm/s). The lowest solubility values followed this order: HEE > RU > BF (2.988 ± 0.07 > 0.205 ± 0.002 > 0.189 ± 0.005 mg/ml). Conclusions According to these results, rutin could be classified as BCS classes III (high solubility/low permeability) and IV (low solubility/low permeability), depending on the plant matrix. Further work needs to be done in order to establish how apply the BCS for research and development of new botanical drugs or for bioequivalence purposes.

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“…It is commonly used as an antioxidant . In addition, a great many studies have reported a number of pharmaceutical activities of rutin, such as anti‐inflammatory, anticancer, antidiabetic, antimicrobial, and neuroprotection effects . Hence, the extraction of bioactive compounds, particularly rutin, from plants or fruits is an important step.…”

Section: Introductionmentioning

confidence: 99%

The mechanism studies of the adsorption–desorption process of rutin from water/ethanol solution and the extract of bitter orange peel by the carboxylated multiwalled carbon nanotubes

Gholizadeh

Ghorbani‐HasanSaraei

Tahermansouri

et al. 2019

J Chinese Chemical Soc

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Carboxylated multiwall carbon nanotubes (MWCNTs-COOH) have been used as an efficient adsorbent for the adsorption of rutin from water/ethanol solution and extract of bitter orange peel. Batch experiments such as solution pH, adsorbent dosage, contact time, concentration of the rutin, and temperature were carried out to study the sorption process. Kinetic studies were well described by a pseudosecondorder kinetic model for MWCNT-COOH. Besides, the adsorbed values of rutin at equilibrium were calculated to be 62.89 mg/g, which agreed well with the experimental data (62.13 mg/g). Isotherm studies showed that the Langmuir isotherm was found to be the best model for the description of the sorption data. ΔG values at temperatures of 298, 308, and 318 K were −1.9, −4.5, and −5.3 kJ/mol, respectively; these negative values for MWCNT-COOH indicated the nature of the spontaneous adsorption process. In addition, rutin molecules can be desorbed from MWCNT-COOH by up to 93.4% of the sorbed amount by increasing the solution pH to 11, which indicates the ability of reutilization of MWCNT-COOH. In addition, the results of high-performance liquid chromatography (HPLC) showed that MWCNT-COOH leads to the adsorption and extraction of rutin about 50% from the extract of bitter orange peel. K E Y W O R D Sadsorption, carbon nanotube, desorption, extract, mechanism, Rutin

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Rutin: A review on extraction, identification and purification methods, biological activities and approaches to enhance its bioavailability

Cited by 428 publications

References 161 publications

Glucose‐mediated protein glycation: Contribution of methanolic extract of Ceratonia siliqua L. in protection and in vitro potential inhibition of acetylcholinesterase

Glucose‐mediated protein glycation: Contribution of methanolic extract of Ceratonia siliqua L. in protection and in vitro potential inhibition of acetylcholinesterase

Matrix effects of the hydroethanolic extract and the butanol fraction of calyces from Physalis peruviana L. on the biopharmaceutics classification of rutin

The mechanism studies of the adsorption–desorption process of rutin from water/ethanol solution and the extract of bitter orange peel by the carboxylated multiwalled carbon nanotubes

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