Rutin, a Quercetin Glycoside, Restores Chemosensitivity in Human Breast Cancer Cells

Iriti, Marcello; Kubina, Robert; Cochis, Andrea; Sorrentino, Rita; Varoni, Elena Maria; Kabała‐Dzik, Agata; Azzimonti, Barbara; Dziedzic, Arkadiusz; Rimondini, Lia; Wojtyczka, Robert D.

doi:10.1002/ptr.5878

Cited by 139 publications

(86 citation statements)

References 27 publications

(36 reference statements)

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“…In this field, natural plant compounds such as flavonoids and stilbenes have received great attention, with the majority (e.g. curcumin, naringenin) reported to show promising anti-tumor activity in preclinical studies [5,22,41,42]. However, bioactive plant compounds have poor bioavailability and poor solubility, which reduce their efficacy in clinical studies [5,7,41,43].…”

Section: Oscc Nano-based Chemopreventionmentioning

confidence: 99%

Nanomedicine, an emerging therapeutic strategy for oral cancer therapy

et al. 2018

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Oral cavity and oropharyngeal carcinomas (oral cancer) represents a significant cause of morbidity and mortality. Despite efforts in improving early diagnosis and treatment, the 5-year survival rate of advanced stage of the disease is less than 63%. The field of nanomedicine has offered promising diagnostic and therapeutic advances in cancer. Indeed, several platforms have been clinically approved for cancer therapy, while other promising systems are undergoing exploration in clinical trials. With its ability to deliver drugs, nucleic acids, and MRI contrast agents with high efficiency, nanomedicine platforms offer the potential to improve drug efficacy and tolerability. The aim of the present mini-review is to summarize the current preclinical status of nanotechnology systems for oral cancer therapy. The nanoplatforms for delivery of chemopreventive agents presented herein resulted in significantly higher anti-tumor activity than free forms of the drug, even against a chemo-resistant cell line. Impressive results have also been obtained using nanoparticles to deliver chemotherapeutics, resulting in reduced toxicity both in vitro and in vivo. Nanoparticles have also led to improvements in efficacy of photodynamic therapies through the development of targeted magnetic nanoparticles. Finally, gene therapy using nanoparticles demonstrated promising results specifically with regards to inhibition of gene expression. Of the few in vivo studies that have been reported, many of these used animal models with several limitations, which will be discussed herein. Lastly, we will discuss several future perspectives in oral cancer nanoparticle-based therapy and the development of appropriate animal models, distinguishing between oral cavity and oropharyngeal carcinoma.

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Section: Oscc Nano-based Chemopreventionmentioning

confidence: 99%

Nanomedicine, an emerging therapeutic strategy for oral cancer therapy

et al. 2018

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“…Flavonoids are classified into the following subclasses: anthocyanins, flavanols, flavanones, flavonols, flavonones, and isoflavones (Amarowicz et al, ; Kabera et al, ; Kumar & Pandey, ). A wide range of pharmacological activities, including antioxidant, antibacterial, hepatoprotective, antinflammatory, and antihyperlipidemic effect, are attributed to flavonoids (Abenavoli et al, ; Azzini et al, ; Belwal, Nabavi, Nabavi, & Habtemariam, ; D'Evoli et al, ; Farhadi, Khameneh, Iranshahi, & Iranshahy, ; Farhat, Drummond, & Al‐Dujaili, ; Iriti et al, ; Miccadei et al, ; Ninfali, Antonini, Frati, & Scarpa, ; Rasouli, Mohammad‐Bagher Hosseini‐Ghazvini, & Khodarahmi, ; Rees, Dodd, & Spencer, ; Riccio et al, ; Tungmunnithum, Thongboonyou, Pholboon, & Yangsabai, ). The term flavonoid generally indicates a phenol compound having a phenylbenzopyran chemical structure with a carbon skeleton of a C6–C3–C6 joined to a chroman ring (Pereira, Valentão, Pereira, & Andrade, ).…”

Section: Phenolic Compoundsmentioning

confidence: 99%

Polyphenols: A concise overview on the chemistry, occurrence, and human health

Durazzo

Lucarini

Souto

et al. 2019

Phytotherapy Research

582

397

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This review gives an updated picture of each class of phenolic compounds and their properties. The most common classification implies the subdivision of phenolics in two main groups: flavonoids (e.g., anthocyanins, flavanols, flavanones, flavonols, flavonones, and isoflavones) and non‐flavonoids (e.g., phenolic acids, xanthones, stilbens, lignans, and tannins) polyphenols. The great interest in polyphenols is associated with their high potential application for food preservation and for therapeutic beneficial use. The relationship between polyphenol intake and human health has been exploited with special reference to cardiovascular diseases, hypertension, diabetes, metabolic syndrome, obesity, and cancer. The use of current existing databases of bioactive compounds including polyphenols is described as key tools for human health research.

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“…Rutin (3,3í,4í,5,7-pentahydroxyflavone-3-rhamnoglucoside), a flavonol, is found in large quantities in passionflower, buckwheat, tea, and apple and possess a variety of pharmacological activities, like antioxidant, cytoprotective, vasoprotective, anticarcinogenic, neuroprotective and cardioprotective (20)(21)(22)(23)(24)(25)(26). Rutin was also reported to stimulate apoptosis in human breast cancer cells, whereas reinstating the chemosensitivity of HER2 negative and triple-negative breast cancer cells (27). Elsayed et al reported that rutin prevents the activity c-Met kinase in TNBC cells thus considerably reducing the growth of TNBC MDA-MB-231/GFP orthotopic xenografts in murine models (28).…”

Section: Vanadium-rutin Complex Sensitizes Breast Cancer Cellsmentioning

confidence: 99%

Vanadium rutin complex sensitizes breast cancer cells via modulation of p53/Bax/Bcl2/VEGF correlated with apoptotic events

Zhu¹,

Wang²,

Liu³

et al. 2020

Acta Poloniae Pharmaceutica - Drug Research

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In pursuit of a novel approach in breast cancer therapy, we explored the ability of vanadium-rutin complex to eradicate cancer by efficiently targeting various apoptotic pathways on human breast cancer cell lines. We provide direct proof of the chemotherapeutic potential of the vanadium-rutin complex by activating p-53 dependent intrinsic apoptosis and modulating the VEGF pathways. The complex was also capable of binding and cleaving CT-DNA at different concentrations. The complex was able to inhibit cell viability at 100 and 150 µM doses in both MCF7 and MDA-MB-231 cells. Furthermore, the complex successfully initiated apoptosis in both cell lines by activating the p53 dependent intrinsic apoptotic pathway. In vitro studies also established that the complex modulated p53, Bax, Bcl2 and VEGF expressions and induced DNA fragmentation in both the cell lines.

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Rutin, a Quercetin Glycoside, Restores Chemosensitivity in Human Breast Cancer Cells

Cited by 139 publications

References 27 publications

Nanomedicine, an emerging therapeutic strategy for oral cancer therapy

Nanomedicine, an emerging therapeutic strategy for oral cancer therapy

Polyphenols: A concise overview on the chemistry, occurrence, and human health

Vanadium rutin complex sensitizes breast cancer cells via modulation of p53/Bax/Bcl2/VEGF correlated with apoptotic events

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