Rutile nano–bio-interactions mediate dissimilar intracellular destiny in human skin cells

Sanches, Priscila Laviola; Souza, Wanderson de; Gemini-Piperni, Sara; Rossi, André L.; Scapin, Sandra Mara Naressi; Midlej, Victor; Sade, Youssef Bacila; Leme, Adriana Franco Paes; Benchimol, Marlene; Rocha, L. A.; Carias, Rosana Bizon Vieira; Borojević, Radovan; Granjeiro, José Mauro; Ribeiro, Ana R.

doi:10.1039/c9na00078j

Cited by 7 publications

(4 citation statements)

References 56 publications

(111 reference statements)

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“…Future development of sunscreen ingredients should therefore comprise a proper design of their chemical surface. Furthermore, Sanches et al stated that different contents of proteins, as well as other molecules (such as calcium or phosphorus) present in the biological medium, conceal TiO 2 NPs and may influence their uptake and distribution [ 125 ]. An important remark is that a thorough analysis of TiO 2 nanomaterial for sunscreen products should be performed also with regard to the nano–bio interactions.…”

Section: Routes Of Exposure and Toxicity Of Tio 2 mentioning

confidence: 99%

Titanium Dioxide Nanoparticles in Food and Personal Care Products—What Do We Know about Their Safety?

et al. 2020

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Titanium dioxide (TiO2) is a material of diverse applications commonly used as a food additive or cosmetic ingredient. Its prevalence in products of everyday use, especially in nanosize, raises concerns about safety. Current findings on the safety of titanium dioxide nanoparticles (TiO2 NPs) used as a food additive or a sunscreen compound are reviewed and systematized in this publication. Although some studies state that TiO2 NPs are not harmful to humans through ingestion or via dermal exposure, there is a considerable number of data that demonstrated their toxic effects in animal models. The final agreement on the safety of this nanomaterial has not yet been reached among researchers. There is also a lack of official, standardized guidelines for thorough characterization of TiO2 NPs in food and cosmetic products, provided by international authorities. Recent advances in the application of ‘green-synthesized’ TiO2 NPs, as well as comparative studies of the properties of ‘biogenic’ and ‘traditional’ nanoparticles, are presented. To conclude, perspectives and directions for further studies on the toxicity of TiO2 NPs are proposed.

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Section: Routes Of Exposure and Toxicity Of Tio 2 mentioning

confidence: 99%

Titanium Dioxide Nanoparticles in Food and Personal Care Products—What Do We Know about Their Safety?

et al. 2020

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“…Further advantages include their specific physicochemical characteristics, such as catalytic properties and relatively low melting point (compared to the macroscopic properties of the metal they are derived from). Moreover, to ensure the safety of their use and appropriate dosage, correlations between these characteristics and the potential toxicity of nanoparticles can be determined using nanotoxicology techniques [ 5 , 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Current Knowledge of Silver and Gold Nanoparticles in Laboratory Research—Application, Toxicity, Cellular Uptake

2021

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Silver and gold nanoparticles can be found in a range of household products related to almost every area of life, including patches, bandages, paints, sportswear, personal care products, food storage equipment, cosmetics, disinfectants, etc. Their confirmed ability to enter the organism through respiratory and digestive systems, skin, and crossing the blood–brain barrier raises questions of their potential effect on cell function. Therefore, this manuscript aimed to summarize recent reports concerning the influence of variables such as size, shape, concentration, type of coating, or incubation time, on effects of gold and silver nanoparticles on cultured cell lines. Due to the increasingly common use of AgNP and AuNP in multiple branches of the industry, further studies on the effects of nanoparticles on different types of cells and the general natural environment are needed to enable their long-term use. However, some environmentally friendly solutions to chemically synthesized nanoparticles are also investigated, such as plant-based synthesis methods.

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“…Compounds such as: silica, alumina, cetylphosphate, manganese dioxide, triethoxycaprylylsilane, PEG among others, contribute to making sunscreens more passive, improving their ability of capture or inhibit the formation of free radicals' species as well as to restrain NPs penetration in the skin (Filipe et al, 2009;Osmond and McCall, 2010;Smijs and Pavel, 2011). These alterations in NPs surface characteristics give rise to the need of a new set of physicochemical characterization, in vitro and in vivo evaluation, since surface modification regulates both interparticle and cell-NP interactions, mediating corona formation that is widely known to induce specific cellular responses such as cellular uptake, intracellular trafficking, accumulation and biodistribution (Oberdörster et al, 2005;Filipe et al, 2009;Osmond and McCall, 2010;Foroozandeh and Aziz, 2015;Ribeiro et al, 2017;Sanches et al, 2019). Results suggest that benefitting from a physical barrier in the form of a coating minimizes ROS formation and consequent dermal toxicity (Yu et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Toxicity Evaluation of TiO2 Nanoparticles on the 3D Skin Model: A Systematic Review

Sanches

Geaquinto

Cruz

et al. 2020

Front. Bioeng. Biotechnol.

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Titanium dioxide nanoparticles (TiO 2 NPs) are regularly used in sunscreens because of their photoprotective capacity. The advantage of using TiO 2 on the nanometer scale is due to its transparency and better UV blocking efficiency. Due to the greater surface area/volume ratio, NPs become more (bio)-reactive giving rise to concerns about their potential toxicity. To evaluate the irritation and corrosion of cosmetics, 3D skin models have been used as an alternative method to animal experimentation. However, it is not known if this model is appropriate to study skin irritation, corrosion and phototoxicity of nanomaterials such as TiO 2 NPs. This systematic review (SR) proposed the following question: Can the toxicity of TiO 2 nanoparticles be evaluated in a 3D skin model? This SR was conducted according to the Preliminary Report on Systematic Review and Meta-Analysis (PRISMA). The protocol was registered in CAMARADES and the ToxRTool evaluation was performed in order to increase the quality and transparency of this search. In this SR, 7 articles were selected, and it was concluded that the 3D skin model has shown to be promising to evaluate the toxicity of TiO 2 NPs. However, most studies have used biological assays that have already been described as interfering with these NPs, demonstrating that misinterpretations can be obtained. This review will focus in the possible efforts that should be done in order to avoid interference of NPs with biological assays applied in 3D in vitro culture.

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Rutile nano–bio-interactions mediate dissimilar intracellular destiny in human skin cells

Abstract: TiO2 NPs’ nano–bio-interactions mediate a distinct intracellular trafficking and destiny in human skin cells.

Cited by 7 publications

References 56 publications

Titanium Dioxide Nanoparticles in Food and Personal Care Products—What Do We Know about Their Safety?

Titanium Dioxide Nanoparticles in Food and Personal Care Products—What Do We Know about Their Safety?

Current Knowledge of Silver and Gold Nanoparticles in Laboratory Research—Application, Toxicity, Cellular Uptake

Toxicity Evaluation of TiO2 Nanoparticles on the 3D Skin Model: A Systematic Review

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