Ruthenium photosensitizer anchored gold nanorods for synergistic photodynamic and photothermal therapy

Abstract

Ruthenium polypyridyl complexes have been widely used as bioprobes and photosensitizers. However, several disadvantages including slow cellular uptake, nonspecific binding with biomolecules and toxicity limit their applications. In this study,...

Spectrum and size controllable synthesis of high-quality gold nanorods using 1,7-dihydroxynaphthalene as a reducing agent

“…Gold nanorods (AuNRs) have broad applications in the fields of biomedicine, 1,2 imaging, 3,4 sensing, 5 and catalysis 6 due to their tunable longitudinal surface plasmon resonance (LSPR). Because the LSPR frequency is directly related to the aspect ratio of AuNRs, 2,7 AuNRs with different aspect ratios and sizes have different application prospects, of which the small-sized AuNRs possessing a high absorption cross section are more attractive for photothermal applications, 8–10 whereas large-sized AuNRs have applications in scattering-related fields. 11 Therefore, the size and spectrum tunable synthesis of AuNRs is particularly important for the study and application of these particles.…”

Recent Progress of Gold-Based Nanostructures towards Future Emblem of Photo-Triggered Cancer Theranostics: A Special Focus on Combinatorial Phototherapies

“…Currently, the combination of CT, PDT, and PTT is creating more attention because of the outstanding sustainable drug release, improved tumor ablation, and low cytotoxicity [ 168 ]. The remarkable therapeutic abilities of synergetic PDT-PTT, [ 173 , 174 , 175 ] CT-PDT, [ 176 , 177 ] and CT-PTT [ 178 , 179 ] are also established. Even though several double-modality therapy nanocarriers have been extensively well-organized, the nanostructure-dependent synergetic triple-modality PDT/PTT/CT therapy remains in the beginning stage.…”

Cellular membrane-targeting ruthenium complexes as efficient photosensitizers for broad-spectrum antibacterial activity

“…The solution was irradiated with a 465 nm surface light (10 mW cm −2 ), and the absorbance of RNO at 440 nm was recorded every 5 min after the light exposure. The singlet linear state oxygen quantum yield with [Ru(bpy 30 was used as a reference. The formula was as follows:…”

“…In these complexes, the central ruthenium atom serves as a structural center that supports a 3D ligand skeleton with a rigid structure; the ligand is easy to substitute or modify for producing a variety of ruthenium(II) complexes with different structural properties. [28][29][30][31][32][33][34][35][36][37][38][39][40] However, the use of ruthenium(II) complexes to target bacterial cell membranes and protect against bacteria by photodynamic therapy is poorly studied. In this manuscript, we present a positively charged Ru(II) complex (Ru-C14) that targets and images cell membranes, and can be used as a photosensitizer for photodynamic therapy (Scheme 1).…”