Ruthenium(II) complexes containing novel asymmetric tridentate ligands: synthesis, structure, electrochemical and spectroscopic properties

Self Cite

A novel dinuclear ruthenium(II) complex [(phen) 2 Ru(mbpibH 2 )Ru(phen) 2 ] 4+ [phen=1,10-phenanthroline; mbpibH 2 =1,3-bis(1,10-phenanthroline[5,6-d]imidazol-2-yl)-benzene] has been synthesized and characterized. The DNA-binding behavior of this complex has been studied by spectroscopic and viscosity measurements. Results suggest that the dinuclear ruthenium(II) complex intercalates into DNA base pairs via its bridging moiety. It has also been found that the dinuclear ruthenium(II) complex displays the enantiopreferential DNA-binding after equilibrium dialysis.

Section: Introductionmentioning

confidence: 99%

DNA Interactions of a Dinuclear Ruthenium(II) Complex Bridged by 1,3-bis(1,10-phenanthroline[5,6-d]imidazol-2-yl)benzene

Chao

Yuan

Zhou

et al. 2006

Self Cite

“…This is probably related to the Molecular structures of the complexes. As revealed by the crystal structures of similar complexes [33], the two phenyl rings in pdtb may rotate away from the 1,2,4-triazine ring with large dihedral angles. On the other hand, for complexes (2) and (3), the two rotated phenyl rings are replaced with a naphthyl ring or a biphenyl ring in the pdta or pdtp ligands, respectively.…”

Section: Viscosity Measurementsmentioning

confidence: 97%

Bis(2,2′-bipyridine)cobalt(III) complexes containing asymmetric ligands: Synthesis, DNA-binding and photocleavage studies

Wang

Chao

Hong

et al. 2005

Self Cite

Three new Co III complexes: [Co(bpy) 2 (pdtb)] 3+ (1), [Co(bpy) 2 (pdta)] 3+ (2) and [Co(bpy) 2 (pdtp)] 3+ (3) have been synthesized and characterized. The DNA binding behavior of the Co III complexes has been investigated by spectroscopic methods and viscosity measurements. The results indicate that the size and shape of the intercalated ligand have a marked effect on the binding affinity of complexes involving CT-DNA. Complexes (2) and (3) have been found to promote cleavage of plasmid pBR 322 DNA from the supercoiled form I to the open circular form II upon irradiation. Photocleavage mechanisms are proposed.

“…Refluxing of the PNH in a glacial acetic acid solution of isatin and 5-methoxyisatin produced pti and ptmi, while ptni was prepared by refluxing of the PNH in an ethanol solution of 5-nitroisatin. [28,29]. The 1 H-1 H COSY spectrum of the complex 2 is given in Fig.…”

Section: Syntheses and Characterizationmentioning

confidence: 98%

Effects of substituent on the DNA-binding of ruthenium(II) complexes containing asymmetric tridentate intercalative ligands

Liu

Chen

et al. 2009

Three novel unsymmetric tridentate ligands, namely, ptmi (ptmi = 3-(1,10-phenanthroline-2-yl)-as-triazino[5,6-f]-5-methoxyisatin), pti (pti = 3-(1,10-phenanthroline-2-yl)-as-triazino-[5,6-f]isatin), ptni (ptni = 3-(1,10-phenanthroline-2-yl)-as-triazino[5,6-f]-5-nitroisatin), and their complexes [Ru(tpy)(ptmi)](ClO 4 ) 2 (tpy = 2,2 0 :6 0 ,2 00 -terpyridine) (1), [Ru(tpy)(pti)](ClO 4 ) 2 (2), and [Ru(tpy)(ptni)](ClO 4 ) 2 (3) were prepared and characterized by elemental analysis, 1 H NMR, ES-MS. The electrochemical behaviors were studied by cyclic voltammetry. The DNA-binding properties of these complexes were investigated by the spectroscopic method, viscosity measurements, and thermal denaturation. Theoretical studies on these complexes were also performed with the density functional theory (DFT) method. The experimental results showed that these complexes bind to calf thymus (CT-DNA) in an intercalative mode. The order of DNA-binding affinities (A) of these complexes is A(1) \ A(2) \ A(3). The trend in the DNA-binding affinities of this series of complexes can be reasonably explained by the DFT calculations.